1FDU
HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 17-BETA-HYDROXYSTEROID DEHYDROGENASE | polymer | 327 | 34949.0 | 4 | UniProt (P14061) Pfam (PF00106) | Homo sapiens (human) | |
| 2 | E, H, K, N (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | F, I, L, O (A, B, C, D) | ESTRADIOL | non-polymer | 272.4 | 4 | Chemie (EST) PubChem (16757676) PubChem (1807201) PubChem (450) PubChem (5757) PubChem (5998) PubChem (10596) PubChem (14880) PubChem (68570) PubChem (177015577) PubChem (43912931) PubChem (44284023) PubChem (46781508) PubChem (667480) PubChem (667515) PubChem (721867) PubChem (1807200) PubChem (928284) PubChem (54403267) PubChem (56624791) PubChem (1258565) PubChem (57041922) PubChem (58650893) PubChem (59084698) PubChem (68014581) PubChem (68209947) PubChem (70220248) PubChem (5317221) PubChem (70864205) PubChem (5745505) PubChem (6328313) PubChem (6432565) PubChem (6560352) PubChem (6603846) PubChem (6918968) PubChem (6919041) PubChem (7000012) PubChem (7004689) PubChem (7048584) PubChem (7048670) PubChem (7061189) PubChem (7067800) PubChem (9795489) PubChem (9811784) PubChem (91740223) PubChem (9903595) PubChem (9938293) PubChem (11869602) PubChem (11870431) PubChem (12313787) PubChem (12313791) PubChem (12313794) PubChem (5317222) PubChem (101691329) PubChem (118548795) PubChem (12313788) PubChem (126969992) PubChem (129010410) PubChem (129317336) PubChem (130307439) PubChem (130307440) PubChem (162947701) PubChem (166849971) PubChem (143489158) PubChem (144605119) PubChem (145157829) PubChem (145610824) PubChem (154109755) PubChem (172873304) | |||
| 4 | G, J, M, P (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 327 (UniProt: P14061)
| PDB | External Database | Details |
|---|---|---|
| Leu 221 | His 221 | engineered mutation |
| Arg 301 | Ala 301 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 139795.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4447.4 | |
| All* | Total formula weight | 144243.2 |
