1FBZ
Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK | polymer | 104 | 11888.3 | 2 | UniProt (P06239) Pfam (PF00017) In PDB | Homo sapiens (human) | |
| 2 | A, B | {4-[2-ACETYLAMINO-2-(3-CARBAMOYL-2-CYCLOHEXYLMETHOXY-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENYL}-PHOSPHONIC ACID | non-polymer | 665.6 | 2 | Chemie (CC1) | |||
| 3 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 104 (UniProt: P06239)
| PDB | External Database | Details |
|---|---|---|
| Cys 42 | Ser 164 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 23776.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1331.2 | |
| All* | Total formula weight | 25107.8 |
