1FBZ
Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CC1 A 150 |
| Chain | Residue |
| A | ARG12 |
| A | GLY93 |
| B | ARG217 |
| B | ARG285 |
| B | HIS286 |
| B | ASN289 |
| A | ARG32 |
| A | GLU35 |
| A | SER36 |
| A | HIS58 |
| A | TYR59 |
| A | LYS60 |
| A | ILE71 |
| A | SER72 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CC1 B 350 |
| Chain | Residue |
| A | GLU1 |
| B | ARG212 |
| B | ARG232 |
| B | SER234 |
| B | GLU235 |
| B | SER236 |
| B | CYS242 |
| B | HIS258 |
| B | TYR259 |
| B | LYS260 |
| B | ARG262 |
| B | SER272 |
| B | ASP292 |
| B | GLY293 |
| B | LEU294 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 194 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P06240","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
