1F6A
Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR ALPHA-SUBUNIT | polymer | 176 | 20318.6 | 1 | UniProt (P12319) Pfam (PF13927) Pfam (PF13895) | Homo sapiens (human) | HIGH AFFINITY IGE-FC RECEPTOR, FC(EPSILON)RI(ALPHA) |
| 2 | B, C (B, D) | IG EPSILON CHAIN C REGION | polymer | 222 | 24821.0 | 2 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (human) | IGE-FC |
| 3 | D (C) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G47477HI) | |||
| 4 | E (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G21381MC) | |||
| 5 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | G (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G08161XL) | |||
| 7 | H (H) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 8 | I, L, M, N, O (A, B, D) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 9 | J, K, P, Q, R (A, D) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 5 | Chemie (CPS) |
Sequence modifications
A: 1 - 176 (UniProt: P12319)
B, D: 330 - 547 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Ala 74 | Asn 99 | engineered mutation |
| Ala 135 | Asn 160 | engineered mutation |
| Ala 142 | Thr 167 | engineered mutation |
| Ala 143 | Val 168 | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Ala 326 | - | cloning artifact |
| Asp 327 | - | cloning artifact |
| Pro 328 | - | cloning artifact |
| Cys 329 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69960.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 3873.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3554.7 | |
| All* | Total formula weight | 77388.9 |
