1F6A
Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR ALPHA-SUBUNIT | polymer | 176 | 20318.6 | 1 | UniProt (P12319) Pfam (PF13927) Pfam (PF13895) | Homo sapiens (human) | HIGH AFFINITY IGE-FC RECEPTOR, FC(EPSILON)RI(ALPHA) |
| 2 | B, C (B, D) | IG EPSILON CHAIN C REGION | polymer | 222 | 24821.0 | 2 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (human) | IGE-FC |
| 3 | D (C) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G47477HI) | |||
| 4 | E (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G21381MC) | |||
| 5 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | G (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G08161XL) | |||
| 7 | H (H) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 8 | I, L, M, N, O (A, B, D) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 9 | J, K, P, Q, R (A, D) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 5 | Chemie (CPS) PubChem (16396400) PubChem (18397788) PubChem (177530666) PubChem (24883538) PubChem (50987450) PubChem (51028881) PubChem (51028882) PubChem (53393728) PubChem (44120060) PubChem (58528211) PubChem (44450441) PubChem (53229977) PubChem (457060) PubChem (3659871) PubChem (107670) PubChem (71774074) PubChem (90488808) PubChem (91746229) PubChem (91809267) PubChem (102565428) PubChem (122361936) PubChem (122362044) PubChem (9895216) PubChem (10371606) PubChem (131632459) PubChem (133645855) PubChem (137704711) PubChem (146159681) |
Sequence modifications
A: 1 - 176 (UniProt: P12319)
B, D: 330 - 547 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Ala 74 | Asn 99 | engineered mutation |
| Ala 135 | Asn 160 | engineered mutation |
| Ala 142 | Thr 167 | engineered mutation |
| Ala 143 | Val 168 | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Ala 326 | - | cloning artifact |
| Asp 327 | - | cloning artifact |
| Pro 328 | - | cloning artifact |
| Cys 329 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69960.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 3873.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3554.7 | |
| All* | Total formula weight | 77388.9 |
