1EX4
HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | INTEGRASE | polymer | 239 | 26427.0 | 2 | UniProt (P04585) Pfam (PF00665) Pfam (PF00552) | Human immunodeficiency virus 1 | |
| 2 | C, D, E, F (A, B) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 4 | Chemie (CPS) PubChem (16396400) PubChem (18397788) PubChem (177530666) PubChem (24883538) PubChem (457060) PubChem (44120060) PubChem (44450441) PubChem (50987450) PubChem (51028881) PubChem (51028882) PubChem (53393728) PubChem (3659871) PubChem (58528211) PubChem (53229977) PubChem (107670) PubChem (71774074) PubChem (9895216) PubChem (10371606) PubChem (90488808) PubChem (91746229) PubChem (91809267) PubChem (102565428) PubChem (122361936) PubChem (122362044) PubChem (131632459) PubChem (133645855) PubChem (137704711) PubChem (146159681) | |||
| 3 | G, H (A, B) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B: 52 - 288 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Gly 50 | - | cloning artifact |
| Ser 51 | - | cloning artifact |
| Ser 56 | Cys 57 | engineered mutation |
| Asp 131 | Trp 132 | engineered mutation |
| Asp 139 | Phe 140 | engineered mutation |
| Lys 185 | Phe 186 | engineered mutation |
| Ser 280 | Cys 281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52854.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2459.5 | |
| All* | Total formula weight | 55313.5 |
