1EKU
CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interferon gamma | polymer | 265 | 31173.4 | 2 | UniProt (P01579) Pfam (PF00714) | Homo sapiens (Human) | IFN-gamma,Immune interferon |
| 2 | C, D, E, F, G... (A, B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | J (B) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 121 (UniProt: P01579)
A, B: 123 - 258 (UniProt: P01579)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Asp 111 | His 134 | engineered mutation |
| Phe 120 | Leu 143 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Thr 122 | - | linker |
| Glu 122 | - | linker |
| Glu 122 | - | linker |
| Gln 122 | - | linker |
| Gln 122 | - | linker |
| Glu 122 | - | linker |
| Gly 122 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62346.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 672.4 | |
| All* | Total formula weight | 63019.2 |
