1E9F
Mutant human thymidylate kinase complexed with TMP and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYMIDYLATE KINASE | polymer | 217 | 24223.7 | 1 | UniProt (P23919) UniProt (P37345) Pfam (PF02223) UniProt (by SIFTS) (P0A720) | HOMO SAPIENS | DTMP KINASE |
| 2 | B (A) | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F (A) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A: 1 - 144 (UniProt: P23919)
A: 149 - 212 (UniProt: P23919)
A: 145 - 148 (UniProt: P37345)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Gly 16 | Arg 16 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 200 | Arg 200 | engineered mutation |
| Ile 184 | Leu 184 | conflict |
| Ile 191 | Leu 191 | conflict |
| Asp 190 | Glu 190 | conflict |
| Ser 183 | Arg 183 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24223.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 798.0 | |
| All* | Total formula weight | 25021.7 |
