1E9F
Mutant human thymidylate kinase complexed with TMP and ADP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | SER20 |
| A | ADP302 |
| A | HOH2014 |
| A | HOH2082 |
| A | HOH2155 |
| A | HOH2156 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | HOH2089 |
| A | HOH2093 |
| A | HOH2093 |
| A | HOH2040 |
| A | HOH2040 |
| A | HOH2089 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TMP A 301 |
| Chain | Residue |
| A | ASP15 |
| A | PHE42 |
| A | LEU57 |
| A | PHE72 |
| A | ARG76 |
| A | ARG97 |
| A | GLY102 |
| A | PHE105 |
| A | HOH2037 |
| A | HOH2082 |
| A | HOH2153 |
| A | HOH2154 |
| A | HOH2155 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP A 302 |
| Chain | Residue |
| A | GLY16 |
| A | ALA17 |
| A | GLY18 |
| A | LYS19 |
| A | SER20 |
| A | THR21 |
| A | ARG143 |
| A | LYS182 |
| A | SER183 |
| A | ILE184 |
| A | ARG192 |
| A | MG401 |
| A | HOH2107 |
| A | HOH2155 |
| A | HOH2156 |
| A | HOH2157 |
| A | HOH2158 |
| A | HOH2160 |
| A | HOH2161 |
| A | HOH2162 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. VVDRYafSGvAFT |
| Chain | Residue | Details |
| A | VAL94-THR106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9826650","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12614151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NN3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1NMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NN3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1NMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NN1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NN5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
