1E9F

Mutant human thymidylate kinase complexed with TMP and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004798	molecular_function	thymidylate kinase activity
A	0005524	molecular_function	ATP binding
A	0006233	biological_process	dTDP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	SER20
A	ADP302
A	HOH2014
A	HOH2082
A	HOH2155
A	HOH2156

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	HOH2089
A	HOH2093
A	HOH2093
A	HOH2040
A	HOH2040
A	HOH2089

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TMP A 301

Chain	Residue
A	ASP15
A	PHE42
A	LEU57
A	PHE72
A	ARG76
A	ARG97
A	GLY102
A	PHE105
A	HOH2037
A	HOH2082
A	HOH2153
A	HOH2154
A	HOH2155

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP A 302

Chain	Residue
A	GLY16
A	ALA17
A	GLY18
A	LYS19
A	SER20
A	THR21
A	ARG143
A	LYS182
A	SER183
A	ILE184
A	ARG192
A	MG401
A	HOH2107
A	HOH2155
A	HOH2156
A	HOH2157
A	HOH2158
A	HOH2160
A	HOH2161
A	HOH2162

---

Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. VVDRYafSGvAFT

Chain	Residue	Details
A	VAL94-THR106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12614151, ECO:0007744|PDB:1NMX, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NN0, ECO:0007744|PDB:1NN3

Chain	Residue	Details
A	GLY16

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12614151, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NMZ, ECO:0007744|PDB:1NN1

Chain	Residue	Details
A	ARG97

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:1NMX, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NN0, ECO:0007744|PDB:1NN3

Chain	Residue	Details
A	LYS182

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NMZ, ECO:0007744|PDB:1NN1, ECO:0007744|PDB:1NN5

Chain	Residue	Details
A	ARG192

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS169

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:9826650

Chain	Residue	Details
A	ARG147

---