1E9E
Mutant human thymidylate kinase (F105Y) complexed with dTMP and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYMIDYLATE KINASE | polymer | 215 | 24140.7 | 1 | UniProt (P23919) Pfam (PF02223) | HOMO SAPIENS (HUMAN) | DTMP KINASE |
| 2 | B (A) | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) PubChem (18531120) PubChem (20711568) PubChem (1139) PubChem (23657880) PubChem (24802545) PubChem (44361457) PubChem (25113134) PubChem (51397487) PubChem (444919) PubChem (9700) PubChem (5274091) PubChem (5748250) PubChem (10147784) PubChem (129069890) PubChem (133126478) PubChem (164603144) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | F (A) | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A: -3 - -1 (PDB: 1E9E)
A: 1 - 212 (UniProt: P23919)
A: 1 - 212 (UniProt: P23919)
| PDB | External Database | Details |
|---|---|---|
| Ala 200 | Arg 200 | engineered mutation |
| Tyr 105 | Phe 105 | engineered mutation |
| Ile 184 | Leu 184 | conflict |
| Ile 191 | Leu 191 | conflict |
| Lys 208 | Gly 208 | conflict |
| Asp 190 | Glu 190 | conflict |
| Ser 183 | Arg 183 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24140.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 798.0 | |
| All* | Total formula weight | 24938.7 |
