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1DX5

Crystal structure of the thrombin-thrombomodulin complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DThrombin light chainpolymer364096.54UniProt (P00734)
Pfam (PF09396)
In PDB
Homo sapiens (Human)Coagulation factor II
2I, J, K, LThrombomodulinpolymer11812691.14UniProt (P07204)
Pfam (PF12662)
In PDB
Homo sapiens (Human)TM,Fetomodulin
3M, N, O, PThrombin heavy chainpolymer25929792.34UniProt (P00734)
Pfam (PF00089)
In PDB
Homo sapiens (Human)Coagulation factor II
4I, J, K, P, LFORMIC ACIDnon-polymer46.05Chemie (FMT)
5I, J, K, LCALCIUM IONnon-polymer40.14Chemie (CA)
6N, O, I, J, P...SODIUM IONnon-polymer23.08Chemie (NA)
7N, O, P, M2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.24Chemie (NAG)
8M, N, O, PL-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamidenon-polymer395.916BIRD (PRD_000288)
Chemie (0GJ)
9waterwater18.0815Chemie (HOH)
Sequence modifications
I, J, K, L: 345 - 462 (UniProt: P07204)
PDBExternal DatabaseDetails
Asp 364Asn 382conflict
Gly 456Arg 474conflict
Gln 457His 475conflict
M, N, O, P: 16 - 247 (UniProt: P00734)
PDBExternal DatabaseDetails
Ile 60Thr 418conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight186319.6
Non-Polymers*Number of molecules37
Total formula weight7793.0
All*Total formula weight194112.6
*Water molecules are not included.

217705

PDB entries from 2024-03-27

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