1DX5
Crystal structure of the thrombin-thrombomodulin complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Thrombin light chain | polymer | 36 | 4096.5 | 4 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (Human) | Coagulation factor II |
2 | I, J, K, L | Thrombomodulin | polymer | 118 | 12691.1 | 4 | UniProt (P07204) Pfam (PF12662) In PDB | Homo sapiens (Human) | TM,Fetomodulin |
3 | M, N, O, P | Thrombin heavy chain | polymer | 259 | 29792.3 | 4 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (Human) | Coagulation factor II |
4 | I, J, K, P, L | FORMIC ACID | non-polymer | 46.0 | 5 | Chemie (FMT) | |||
5 | I, J, K, L | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
6 | N, O, I, J, P... | SODIUM ION | non-polymer | 23.0 | 8 | Chemie (NA) | |||
7 | N, O, P, M | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
8 | M, N, O, P | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide | non-polymer | 395.9 | 16 | BIRD (PRD_000288) Chemie (0GJ) | |||
9 | water | water | 18.0 | 815 | Chemie (HOH) |
Sequence modifications
I, J, K, L: 345 - 462 (UniProt: P07204)
M, N, O, P: 16 - 247 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Asp 364 | Asn 382 | conflict |
Gly 456 | Arg 474 | conflict |
Gln 457 | His 475 | conflict |
PDB | External Database | Details |
---|---|---|
Ile 60 | Thr 418 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 186319.6 | |
Non-Polymers* | Number of molecules | 37 |
Total formula weight | 7793.0 | |
All* | Total formula weight | 194112.6 |