1CS4
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TYPE V ADENYLATE CYCLASE | polymer | 225 | 25526.5 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (dog) | ATP PYROPHOSPHATE-LYASE |
| 2 | B (B) | TYPE II ADENYLATE CYCLASE | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (Norway rat) | ATP PYROPHOSPHATE-LYASE, ADENYLYL CYCLASE |
| 3 | C (C) | GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) | polymer | 394 | 45769.5 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN |
| 4 | D, J (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | E (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) | |||
| 6 | F, I (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 7 | G (A) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) | |||
| 8 | H (B) | 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE | non-polymer | 331.2 | 1 | Chemie (101) | |||
| 9 | K (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 10 | L (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 11 | M, N, O (A, B, C) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 363 - 580 (UniProt: P30803)
| PDB | External Database | Details |
|---|---|---|
| Met 476 | Val 476 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95013.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1931.5 | |
| All* | Total formula weight | 96944.5 |
