1CS4
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TYPE V ADENYLATE CYCLASE | polymer | 225 | 25526.5 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (dog) | ATP PYROPHOSPHATE-LYASE |
| 2 | B (B) | TYPE II ADENYLATE CYCLASE | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (Norway rat) | ATP PYROPHOSPHATE-LYASE, ADENYLYL CYCLASE |
| 3 | C (C) | GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) | polymer | 394 | 45769.5 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN |
| 4 | D, J (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) PubChem (16757823) PubChem (3413) PubChem (176519959) PubChem (47936) PubChem (44120009) PubChem (44363887) PubChem (46783813) PubChem (69645774) PubChem (73759682) PubChem (6603852) PubChem (6604815) PubChem (6610344) PubChem (337799) PubChem (90751269) PubChem (9844450) PubChem (91213948) PubChem (486148) PubChem (92209816) PubChem (92209817) PubChem (95566308) PubChem (95566309) PubChem (13361560) PubChem (13361561) PubChem (13361564) PubChem (13361565) PubChem (92209815) PubChem (5702265) PubChem (124404343) PubChem (117777632) PubChem (133612037) PubChem (124303810) PubChem (124352399) PubChem (124815399) PubChem (124815400) PubChem (129009935) PubChem (129010250) PubChem (139024465) PubChem (142159939) PubChem (146225314) PubChem (159992414) PubChem (162705519) PubChem (162884402) PubChem (163835172) PubChem (168749335) PubChem (171322913) | |||
| 6 | F, I (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) PubChem (4478249) | |||
| 7 | G (A) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) PubChem (4995) | |||
| 8 | H (B) | 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE | non-polymer | 331.2 | 1 | Chemie (101) PubChem (1467) PubChem (167350) PubChem (59153839) PubChem (86308793) | |||
| 9 | K (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 10 | L (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) PubChem (135398675) PubChem (135476260) PubChem (136073095) PubChem (136440011) PubChem (137176535) PubChem (169450542) | |||
| 11 | M, N, O (A, B, C) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 363 - 580 (UniProt: P30803)
| PDB | External Database | Details |
|---|---|---|
| Met 476 | Val 476 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95013.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1931.5 | |
| All* | Total formula weight | 96944.5 |
