1CJU
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADENYLATE CYCLASE, TYPE V | polymer | 217 | 24495.4 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus (dog) | PROTEIN VC1 |
| 2 | B (B) | ADENYLATE CYCLASE, TYPE II | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (Norway rat) | PROTEIN IIC2, ATP PYROPHOSPHATE-LYASE, ADENYLYL CYCLASE |
| 3 | C (C) | GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) | polymer | 402 | 46656.4 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | ALPHA SUBUNIT OF ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN, GS-ALPHA, PROTEIN GSA |
| 4 | D, E, H (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | F (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) | |||
| 6 | G (A) | 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE | non-polymer | 475.2 | 1 | Chemie (DAD) | |||
| 7 | I (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | J (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 9 | K, L, M (A, B, C) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A: 364 - 580 (UniProt: P30803)
| PDB | External Database | Details |
|---|---|---|
| Met 476 | Val 476 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94868.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1533.3 | |
| All* | Total formula weight | 96402.1 |
