1A35
HUMAN TOPOISOMERASE I/DNA COMPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3') | polymer | 22 | 6920.2 | 1 | |||
| 2 | B (D) | DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3') | polymer | 22 | 7094.6 | 1 | |||
| 3 | C (A) | PROTEIN (DNA TOPOISOMERASE I) | polymer | 591 | 70022.9 | 1 | UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) | Homo sapiens (human) | |
| 4 | D, E, F (C, D, A) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A: 175 - 765 (UniProt: P11387)
| PDB | External Database | Details |
|---|---|---|
| Phe 723 | Tyr 723 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 84037.7 | |
| All* | Total formula weight | 84037.7 |
