1T5A
Human Pyruvate Kinase M2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase, M2 isozyme | polymer | 567 | 62128.3 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | |
| 2 | E, IA, O, X (A, D, B, C) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) PubChem (16219368) PubChem (718) PubChem (10267) PubChem (172313) PubChem (24802138) PubChem (440117) PubChem (46937007) PubChem (5702629) PubChem (89534552) PubChem (445557) PubChem (92209485) PubChem (92209486) PubChem (12800340) PubChem (92209487) PubChem (124383956) PubChem (124540446) PubChem (135053794) PubChem (123134048) PubChem (124202619) PubChem (124427861) PubChem (124524513) PubChem (124604817) PubChem (130233858) PubChem (133126640) PubChem (135055131) PubChem (140434362) PubChem (146159004) PubChem (160510795) | |||
| 3 | F, JA, P, Y (A, D, B, C) | OXALATE ION | non-polymer | 88.0 | 4 | Chemie (OXL) PubChem (71081) | |||
| 4 | G, KA, Q, Z (A, D, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) PubChem (1061) | |||
| 5 | AA, H, LA, R (C, A, D, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 6 | BA, I, MA, S (C, A, D, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) PubChem (813) | |||
| 7 | CA, DA, EA, FA, GA... (C, A, D, B) | GLYCEROL | non-polymer | 92.1 | 20 | Chemie (GOL) PubChem (753) | |||
| 8 | SA, TA, UA, VA (A, B, C, D) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Met -35 | - | cloning artifact |
| Arg -34 | - | cloning artifact |
| Gly -33 | - | cloning artifact |
| Ser -32 | - | cloning artifact |
| His -31 | - | cloning artifact |
| His -30 | - | cloning artifact |
| His -29 | - | cloning artifact |
| His -28 | - | cloning artifact |
| His -27 | - | cloning artifact |
| His -26 | - | cloning artifact |
| Gly -25 | - | cloning artifact |
| Met -24 | - | cloning artifact |
| Ala -23 | - | cloning artifact |
| Ser -22 | - | cloning artifact |
| Met -21 | - | cloning artifact |
| Thr -20 | - | cloning artifact |
| Gly -19 | - | cloning artifact |
| Gly -18 | - | cloning artifact |
| Gln -17 | - | cloning artifact |
| Gln -16 | - | cloning artifact |
| Met -15 | - | cloning artifact |
| Gly -14 | - | cloning artifact |
| Arg -13 | - | cloning artifact |
| Asp -12 | - | cloning artifact |
| Leu -11 | - | cloning artifact |
| Tyr -10 | - | cloning artifact |
| Asp -9 | - | cloning artifact |
| Asp -8 | - | cloning artifact |
| Asp -7 | - | cloning artifact |
| Asp -6 | - | cloning artifact |
| Lys -5 | - | cloning artifact |
| Asp -4 | - | cloning artifact |
| His -3 | - | cloning artifact |
| Pro -2 | - | cloning artifact |
| Phe -1 | - | cloning artifact |
| Thr 0 | - | cloning artifact |
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 248513.3 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 4187.9 | |
| All* | Total formula weight | 252701.2 |
