12E8

2E8 FAB FRAGMENT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (L, M)	IGG1-KAPPA 2E8 FAB (LIGHT CHAIN)	polymer	214	23541.0	2	GenBank (10121892)	Mus musculus (house mouse)
2	B, D (H, P)	IGG1-KAPPA 2E8 FAB (HEAVY CHAIN)	polymer	221	23878.6	2	PIR (S49220)	Mus musculus (house mouse)
3	E, F, G, H (L, H, M, P)	water	water		18.0	767	Chemie (HOH)

Sequence modifications

L, M: 1 - 214 (GenBank: 10121892)

PDB	External Database	Details
Ile 21	Val 42	conflict
Ala 32	Asn 53	conflict
Leu 46	Ala 67	conflict
Met 47	Leu 68	conflict
Asn 53	Tyr 74	conflict
Thr 56	Ser 77	conflict
Met 78	Val 99	conflict
Asp 85	Glu 106	conflict
Ser 92	Asn 113	conflict
Ala 163	Trp 184	conflict

H, P: 2 - 214 (PIR: S49220)

PDB	External Database	Details
Gln 3	Lys 3	conflict
Gln 5	Leu 5	conflict
Gln 6	Glu 6	conflict
Val 11	Leu 11	conflict
Arg 13	Lys 13	conflict
Tyr 32	Thr 32	conflict
Ile 34	Met 34	conflict
Lys 43	Gln 43	conflict
Trp 50	Arg 50	conflict
Glu 53	Ala 54	conflict
Ile 54	Asn 55	conflict
Asp 56	Glu 57	conflict
Thr 57	Ile 58	conflict
Glu 58	Lys 59	conflict
Val 60	Asp 61	conflict
Lys 66	Thr 67	conflict
Met 69	Ile 70	conflict
Ser 75	Thr 76	conflict
-	Val 97	deletion
Asn 93	Arg 98	conflict
Ala 94	Arg 99	conflict
His 96	-	insertion
Asp 97	-	insertion
Asp 99	Gly 102	conflict
Arg 100	Ser 103	conflict
Gly 100	Ser 104	conflict
Arg 100	Gln 105	conflict
Phe 100	Glu 106	conflict
Leu 108	Thr 114	conflict
Val 109	Leu 115	conflict
Ala 113	Ser 119	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	94839.2
All*	Total formula weight	94839.2

*Water molecules are not included.