11YC

The structure of human Vacuolar Protein Sorting 34 catalytic domain bound to RD-II-123

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Phosphatidylinositol 3-kinase catalytic subunit type 3	polymer	594	68149.9	1	UniProt (Q8NEB9)	Homo sapiens (human)	PI3-kinase type 3,PI3K type 3,PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34
2	B (B)	(8S)-3-(6-butyl-1,3-benzothiazol-2-yl)pyrazolo[1,5-a]pyrimidine	non-polymer		308.4	1	Chemie (A1DAY)
3	C (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	D (B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG) PubChem (8117)
5	E, F, G, H (B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL) PubChem (312)
6	I (B)	water	water		18.0	35	Chemie (HOH)

Sequence modifications

B: 290 - 871 (UniProt: Q8NEB9)

PDB	External Database	Details
Met 278	-	expression tag
Gly 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68149.9
Non-Polymers*	Number of molecules	7
	Total formula weight	618.4
All*	Total formula weight	68768.3

*Water molecules are not included.