11GN
Crystal structure of mSTING in complex with 3'3'-di-AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, E) | Stimulator of interferon genes protein | polymer | 186 | 21230.1 | 4 | UniProt (Q3TBT3) | Mus musculus (house mouse) | mSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,MMITA,Transmembrane protein 173 |
| 2 | E, G (A, D) | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide | non-polymer | 658.4 | 2 | Chemie (2BA) | |||
| 3 | F (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | H, I, J, K (A, B, D, E) | water | water | 18.0 | 831 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 153 - 336 (UniProt: Q3TBT3)
| PDB | External Database | Details |
|---|---|---|
| Gly 151 | - | expression tag |
| Ser 152 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 84920.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1378.9 | |
| All* | Total formula weight | 86299.2 |
