11EX
Crystal structure of hIgG1-Fc in complex with FcRL5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Fc receptor-like protein 5 | polymer | 261 | 29625.7 | 1 | UniProt (Q96RD9) Pfam (PF13895) | Homo sapiens (human) | FcR-like protein 5,FcRL5,BXMAS1,Fc receptor homolog 5,FcRH5,Immune receptor translocation-associated protein 2 |
| 2 | B, C (A, B) | Immunoglobulin heavy constant gamma 1 | polymer | 211 | 23844.9 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE |
| 3 | D (D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | In PDB GlyTouCan (G82348BZ) | |||
| 4 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 1 | In PDB GlyTouCan (G80858MF) | |||
| 5 | F (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) PubChem (24139) |
Sequence modifications
C: 20 - 280 (UniProt: Q96RD9)
A, B: 235 - 445 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | Phe 26 | engineered mutation |
| Glu 43 | Lys 45 | engineered mutation |
| Pro 109 | Leu 111 | engineered mutation |
| Gly 126 | Glu 128 | engineered mutation |
| Arg 153 | His 155 | engineered mutation |
| Arg 249 | Trp 251 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 320 | Lys 203 | engineered mutation |
| Ala 342 | Gln 225 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 77315.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2520.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 80057.0 |
