10ZJ

Structure of Cbl-B bound to compound 8

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	E3 ubiquitin-protein ligase CBL-B	polymer	410	47772.6	1	UniProt (Q13191)	Homo sapiens (human)	Casitas B-lineage lymphoma proto-oncogene b,RING finger protein 56,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,Signal transduction protein CBL-B
2	B (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
3	C, D (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN) PubChem (32051)
4	E (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	F (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
6	G (A)	6-{[(3,3-difluoropropyl)amino]methyl}-2-(3-{3-[(R)-fluoro(4-methyl-4H-1,2,4-triazol-3-yl)methyl]oxetan-3-yl}phenyl)-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one	non-polymer		553.5	1	Chemie (A1DCC)
7	H (A)	water	water		18.0	310	Chemie (HOH)

Sequence modifications

A: 34 - 427 (UniProt: Q13191)

PDB	External Database	Details
Met 18	-	initiating methionine
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
Gly 27	-	expression tag
Glu 28	-	expression tag
Asn 29	-	expression tag
Leu 30	-	expression tag
Tyr 31	-	expression tag
Phe 32	-	expression tag
Gln 33	-	expression tag
Ser 35	Pro 35	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	47772.6
Non-Polymers*	Number of molecules	6
	Total formula weight	862.8
All*	Total formula weight	48635.3

*Water molecules are not included.