10ZF

Structure of c-Cbl bound to compound 33

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutathione S-transferase class-mu 26 kDa isozyme,E3 ubiquitin-protein ligase CBL	polymer	628	72787.8	1	UniProt (P08515) UniProt (P22681)	Schistosoma japonicum (Blood fluke)
2	B (A)	2-{3-[(1r,3r)-3-methoxy-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(1-methylcyclobutyl)amino]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one	non-polymer		539.6	1	Chemie (A1DCD)
3	C, D (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN) PubChem (32051)
4	E (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
5	F (A)	water	water		18.0	70	Chemie (HOH)

Sequence modifications

A: -181 - 35 (UniProt: P08515)

PDB	External Database	Details
Met -189	-	initiating methionine
His -188	-	expression tag
His -187	-	expression tag
His -186	-	expression tag
His -185	-	expression tag
His -184	-	expression tag
His -183	-	expression tag
Gly -182	-	expression tag
Lys -49	Glu 134	conflict
Ser 36	-	linker
Asp 37	-	linker
Gly 38	-	linker
Glu 39	-	linker
Asn 40	-	linker
Leu 41	-	linker
Tyr 42	-	linker
Phe 43	-	linker
Gln 44	-	linker
Gly 45	-	linker
Ser 46	-	linker

A: 47 - 435 (UniProt: P22681)

PDB	External Database	Details
Gly 436	-	expression tag
Asn 437	-	expression tag
Ser 438	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	72787.8
Non-Polymers*	Number of molecules	4
	Total formula weight	694.7
All*	Total formula weight	73482.5

*Water molecules are not included.