10SL
Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with Hesperadin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Putative rac serine-threonine kinase | polymer | 361 | 41729.3 | 2 | UniProt (Q4E2L0) Pfam (PF00069) | Trypanosoma cruzi | |
| 2 | C, D (A, B) | N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE | non-polymer | 516.7 | 2 | Chemie (H1N) | |||
| 3 | E (B) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B: 123 - 474 (UniProt: Q4E2L0)
| PDB | External Database | Details |
|---|---|---|
| Met 122 | - | initiating methionine |
| Ile 185 | Thr 185 | engineered mutation |
| Phe 227 | Val 227 | engineered mutation |
| Ser 314 | Asn 314 | engineered mutation |
| Leu 475 | - | expression tag |
| Glu 476 | - | expression tag |
| His 477 | - | expression tag |
| His 478 | - | expression tag |
| His 479 | - | expression tag |
| His 480 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83458.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1135.4 | |
| All* | Total formula weight | 84593.9 |
