10RI

Dimeric complex of VEGF, VEGFR2 and Neuropilin 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform VEGF-1 of Vascular endothelial growth factor A, long form	polymer	175	20787.7	2	UniProt (Q00731)	Mus musculus (house mouse)	L-VEGF,Vascular permeability factor,VPF
2	C, F (C, D)	Vascular endothelial growth factor receptor 2	polymer	754	84499.0	2	UniProt (P35918)	Mus musculus (house mouse)	VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase NYK,Protein-tyrosine kinase receptor flk-1
3	D, E (E, F)	Neuropilin-1	polymer	847	95312.6	2	UniProt (P97333)	Mus musculus (house mouse)	A5 protein
4	G, H, I, L, O... (C, E, F, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG) PubChem (24139)
5	J, K, M, N (E, F)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA) PubChem (271)

Sequence modifications

A, B: 27 - 190 (UniProt: Q00731)

PDB	External Database	Details
Glu 16	-	expression tag
Leu 17	-	expression tag
Glu 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag

C, D: 20 - 760 (UniProt: P35918)

PDB	External Database	Details
Glu 17	-	expression tag
Leu 18	-	expression tag
Glu 19	-	expression tag
Gly 761	-	expression tag
Thr 762	-	expression tag
His 763	-	expression tag
His 764	-	expression tag
His 765	-	expression tag
His 766	-	expression tag
His 767	-	expression tag
His 768	-	expression tag
His 769	-	expression tag
His 770	-	expression tag

E, F: 22 - 855 (UniProt: P97333)

PDB	External Database	Details
Glu 19	-	expression tag
Leu 20	-	expression tag
Glu 21	-	expression tag
Gly 856	-	expression tag
Thr 857	-	expression tag
His 858	-	expression tag
His 859	-	expression tag
His 860	-	expression tag
His 861	-	expression tag
His 862	-	expression tag
His 863	-	expression tag
His 864	-	expression tag
His 865	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	401198.7
Non-Polymers*	Number of molecules	10
	Total formula weight	1487.6
All*	Total formula weight	402686.3

*Water molecules are not included.