10RI

Dimeric complex of VEGF, VEGFR2 and Neuropilin 1

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0001525	biological_process	angiogenesis
E	0001569	biological_process	branching involved in blood vessel morphogenesis
E	0001570	biological_process	vasculogenesis
E	0001755	biological_process	neural crest cell migration
E	0001764	biological_process	neuron migration
E	0002040	biological_process	sprouting angiogenesis
E	0002042	biological_process	cell migration involved in sprouting angiogenesis
E	0003148	biological_process	outflow tract septum morphogenesis
E	0003253	biological_process	cardiac neural crest cell migration involved in outflow tract morphogenesis
E	0005021	molecular_function	vascular endothelial growth factor receptor activity
E	0005096	molecular_function	GTPase activator activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005769	cellular_component	early endosome
E	0005829	cellular_component	cytosol
E	0005883	cellular_component	neurofilament
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006930	biological_process	substrate-dependent cell migration, cell extension
E	0007229	biological_process	integrin-mediated signaling pathway
E	0007411	biological_process	axon guidance
E	0007413	biological_process	axonal fasciculation
E	0007507	biological_process	heart development
E	0008045	biological_process	motor neuron axon guidance
E	0009611	biological_process	response to wounding
E	0009986	cellular_component	cell surface
E	0010595	biological_process	positive regulation of endothelial cell migration
E	0010641	biological_process	positive regulation of platelet-derived growth factor receptor signaling pathway
E	0016358	biological_process	dendrite development
E	0016477	biological_process	cell migration
E	0017154	molecular_function	semaphorin receptor activity
E	0019838	molecular_function	growth factor binding
E	0019901	molecular_function	protein kinase binding
E	0021612	biological_process	facial nerve structural organization
E	0021636	biological_process	trigeminal nerve morphogenesis
E	0021637	biological_process	trigeminal nerve structural organization
E	0021649	biological_process	vestibulocochlear nerve structural organization
E	0021785	biological_process	branchiomotor neuron axon guidance
E	0021828	biological_process	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
E	0030335	biological_process	positive regulation of cell migration
E	0030424	cellular_component	axon
E	0030426	cellular_component	growth cone
E	0030517	biological_process	negative regulation of axon extension
E	0030947	biological_process	regulation of vascular endothelial growth factor receptor signaling pathway
E	0031290	biological_process	retinal ganglion cell axon guidance
E	0031966	cellular_component	mitochondrial membrane
E	0032489	biological_process	regulation of Cdc42 protein signal transduction
E	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
E	0035767	biological_process	endothelial cell chemotaxis
E	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
E	0036486	biological_process	ventral trunk neural crest cell migration
E	0038085	molecular_function	vascular endothelial growth factor binding
E	0038189	biological_process	neuropilin signaling pathway
E	0038190	biological_process	VEGF-activated neuropilin signaling pathway
E	0042060	biological_process	wound healing
E	0042327	biological_process	positive regulation of phosphorylation
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0043542	biological_process	endothelial cell migration
E	0045211	cellular_component	postsynaptic membrane
E	0045766	biological_process	positive regulation of angiogenesis
E	0046718	biological_process	symbiont entry into host cell
E	0048008	biological_process	platelet-derived growth factor receptor signaling pathway
E	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
E	0048012	biological_process	hepatocyte growth factor receptor signaling pathway
E	0048485	biological_process	sympathetic nervous system development
E	0048666	biological_process	neuron development
E	0048841	biological_process	regulation of axon extension involved in axon guidance
E	0048842	biological_process	positive regulation of axon extension involved in axon guidance
E	0048843	biological_process	negative regulation of axon extension involved in axon guidance
E	0048844	biological_process	artery morphogenesis
E	0048846	biological_process	axon extension involved in axon guidance
E	0050918	biological_process	positive chemotaxis
E	0050921	biological_process	positive regulation of chemotaxis
E	0051491	biological_process	positive regulation of filopodium assembly
E	0051496	biological_process	positive regulation of stress fiber assembly
E	0051894	biological_process	positive regulation of focal adhesion assembly
E	0060385	biological_process	axonogenesis involved in innervation
E	0060666	biological_process	dichotomous subdivision of terminal units involved in salivary gland branching
E	0060978	biological_process	angiogenesis involved in coronary vascular morphogenesis
E	0060980	biological_process	cell migration involved in coronary vasculogenesis
E	0060982	biological_process	coronary artery morphogenesis
E	0061298	biological_process	retina vasculature development in camera-type eye
E	0061299	biological_process	retina vasculature morphogenesis in camera-type eye
E	0061441	biological_process	renal artery morphogenesis
E	0061549	biological_process	sympathetic ganglion development
E	0061551	biological_process	trigeminal ganglion development
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0071526	biological_process	semaphorin-plexin signaling pathway
E	0071673	biological_process	positive regulation of smooth muscle cell chemotaxis
E	0071679	biological_process	commissural neuron axon guidance
E	0090050	biological_process	positive regulation of cell migration involved in sprouting angiogenesis
E	0097374	biological_process	sensory neuron axon guidance
E	0097443	cellular_component	sorting endosome
E	0097475	biological_process	motor neuron migration
E	0097490	biological_process	sympathetic neuron projection extension
E	0097491	biological_process	sympathetic neuron projection guidance
E	0098978	cellular_component	glutamatergic synapse
E	0099173	biological_process	postsynapse organization
E	0150018	biological_process	basal dendrite development
E	0150020	biological_process	basal dendrite arborization
E	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
E	1901166	biological_process	neural crest cell migration involved in autonomic nervous system development
E	1902946	biological_process	protein localization to early endosome
E	1903375	biological_process	facioacoustic ganglion development
E	1904754	biological_process	positive regulation of vascular associated smooth muscle cell migration
E	1904835	biological_process	dorsal root ganglion morphogenesis
E	1905040	biological_process	otic placode development
E	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
F	0001525	biological_process	angiogenesis
F	0001569	biological_process	branching involved in blood vessel morphogenesis
F	0001570	biological_process	vasculogenesis
F	0001755	biological_process	neural crest cell migration
F	0001764	biological_process	neuron migration
F	0002040	biological_process	sprouting angiogenesis
F	0002042	biological_process	cell migration involved in sprouting angiogenesis
F	0003148	biological_process	outflow tract septum morphogenesis
F	0003253	biological_process	cardiac neural crest cell migration involved in outflow tract morphogenesis
F	0005021	molecular_function	vascular endothelial growth factor receptor activity
F	0005096	molecular_function	GTPase activator activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005769	cellular_component	early endosome
F	0005829	cellular_component	cytosol
F	0005883	cellular_component	neurofilament
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006930	biological_process	substrate-dependent cell migration, cell extension
F	0007229	biological_process	integrin-mediated signaling pathway
F	0007411	biological_process	axon guidance
F	0007413	biological_process	axonal fasciculation
F	0007507	biological_process	heart development
F	0008045	biological_process	motor neuron axon guidance
F	0009611	biological_process	response to wounding
F	0009986	cellular_component	cell surface
F	0010595	biological_process	positive regulation of endothelial cell migration
F	0010641	biological_process	positive regulation of platelet-derived growth factor receptor signaling pathway
F	0016358	biological_process	dendrite development
F	0016477	biological_process	cell migration
F	0017154	molecular_function	semaphorin receptor activity
F	0019838	molecular_function	growth factor binding
F	0019901	molecular_function	protein kinase binding
F	0021612	biological_process	facial nerve structural organization
F	0021636	biological_process	trigeminal nerve morphogenesis
F	0021637	biological_process	trigeminal nerve structural organization
F	0021649	biological_process	vestibulocochlear nerve structural organization
F	0021785	biological_process	branchiomotor neuron axon guidance
F	0021828	biological_process	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
F	0030335	biological_process	positive regulation of cell migration
F	0030424	cellular_component	axon
F	0030426	cellular_component	growth cone
F	0030517	biological_process	negative regulation of axon extension
F	0030947	biological_process	regulation of vascular endothelial growth factor receptor signaling pathway
F	0031290	biological_process	retinal ganglion cell axon guidance
F	0031966	cellular_component	mitochondrial membrane
F	0032489	biological_process	regulation of Cdc42 protein signal transduction
F	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
F	0035767	biological_process	endothelial cell chemotaxis
F	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
F	0036486	biological_process	ventral trunk neural crest cell migration
F	0038085	molecular_function	vascular endothelial growth factor binding
F	0038189	biological_process	neuropilin signaling pathway
F	0038190	biological_process	VEGF-activated neuropilin signaling pathway
F	0042060	biological_process	wound healing
F	0042327	biological_process	positive regulation of phosphorylation
F	0043005	cellular_component	neuron projection
F	0043025	cellular_component	neuronal cell body
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	0043542	biological_process	endothelial cell migration
F	0045211	cellular_component	postsynaptic membrane
F	0045766	biological_process	positive regulation of angiogenesis
F	0046718	biological_process	symbiont entry into host cell
F	0048008	biological_process	platelet-derived growth factor receptor signaling pathway
F	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
F	0048012	biological_process	hepatocyte growth factor receptor signaling pathway
F	0048485	biological_process	sympathetic nervous system development
F	0048666	biological_process	neuron development
F	0048841	biological_process	regulation of axon extension involved in axon guidance
F	0048842	biological_process	positive regulation of axon extension involved in axon guidance
F	0048843	biological_process	negative regulation of axon extension involved in axon guidance
F	0048844	biological_process	artery morphogenesis
F	0048846	biological_process	axon extension involved in axon guidance
F	0050918	biological_process	positive chemotaxis
F	0050921	biological_process	positive regulation of chemotaxis
F	0051491	biological_process	positive regulation of filopodium assembly
F	0051496	biological_process	positive regulation of stress fiber assembly
F	0051894	biological_process	positive regulation of focal adhesion assembly
F	0060385	biological_process	axonogenesis involved in innervation
F	0060666	biological_process	dichotomous subdivision of terminal units involved in salivary gland branching
F	0060978	biological_process	angiogenesis involved in coronary vascular morphogenesis
F	0060980	biological_process	cell migration involved in coronary vasculogenesis
F	0060982	biological_process	coronary artery morphogenesis
F	0061298	biological_process	retina vasculature development in camera-type eye
F	0061299	biological_process	retina vasculature morphogenesis in camera-type eye
F	0061441	biological_process	renal artery morphogenesis
F	0061549	biological_process	sympathetic ganglion development
F	0061551	biological_process	trigeminal ganglion development
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0071526	biological_process	semaphorin-plexin signaling pathway
F	0071673	biological_process	positive regulation of smooth muscle cell chemotaxis
F	0071679	biological_process	commissural neuron axon guidance
F	0090050	biological_process	positive regulation of cell migration involved in sprouting angiogenesis
F	0097374	biological_process	sensory neuron axon guidance
F	0097443	cellular_component	sorting endosome
F	0097475	biological_process	motor neuron migration
F	0097490	biological_process	sympathetic neuron projection extension
F	0097491	biological_process	sympathetic neuron projection guidance
F	0098978	cellular_component	glutamatergic synapse
F	0099173	biological_process	postsynapse organization
F	0150018	biological_process	basal dendrite development
F	0150020	biological_process	basal dendrite arborization
F	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
F	1901166	biological_process	neural crest cell migration involved in autonomic nervous system development
F	1902946	biological_process	protein localization to early endosome
F	1903375	biological_process	facioacoustic ganglion development
F	1904754	biological_process	positive regulation of vascular associated smooth muscle cell migration
F	1904835	biological_process	dorsal root ganglion morphogenesis
F	1905040	biological_process	otic placode development
F	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00249
Number of Residues	13
Details	PDGF_1 Platelet-derived growth factor (PDGF) family signature. PSCVplmRCAGCC

Chain	Residue	Details
A	PRO74-CYS86

---

site_id	PS00740
Number of Residues	41
Details	MAM_1 MAM domain signature. GnFIysqAdenqkgkvar.LvspvVysqssahCMtFwYhmsG

Chain	Residue	Details
E	GLY690-GLY730

---

site_id	PS01285
Number of Residues	30
Details	FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. GWtpgedsyke......WIqVDlgllrfVtaVgTQG

Chain	Residue	Details
E	GLY314-GLY343
E	GLY470-GLY502

---

site_id	PS01286
Number of Residues	17
Details	FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pvswetgis..MRfEVyGC

Chain	Residue	Details
E	PRO408-CYS424
E	PRO566-CYS583

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Domain: {"description":"Ig-like C2-type 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	198
Details	Domain: {"description":"Ig-like C2-type 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	172
Details	Domain: {"description":"Ig-like C2-type 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	238
Details	Domain: {"description":"Ig-like C2-type 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	172
Details	Domain: {"description":"Ig-like C2-type 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	32
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	228
Details	Domain: {"description":"CUB 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	236
Details	Domain: {"description":"CUB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	298
Details	Domain: {"description":"F5/8 type C 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O14786","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19656770","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---