10OZ
Structure of PDE5 PDE6 chimera
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cGMP-specific 3',5'-cyclic phosphodiesterase PDE5-PDE6 chimera | polymer | 800 | 91715.9 | 2 | UniProt (P16586) UniProt (Q28156) Pfam (PF01590) Pfam (PF00233) | Bos taurus (domestic cattle) | PDE V-C1,cGMP phosphodiesterase 6C,cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE |
| 2 | C, D (C, D) | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | polymer | 107 | 11855.6 | 2 | UniProt (P04972) Pfam (PF04868) | Bos taurus (domestic cattle) | GMP-PDE gamma |
| 3 | E, J (A, B) | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | non-polymer | 474.6 | 2 | Chemie (VIA) | |||
| 4 | F, I (A, B) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 2 | Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904) | |||
| 5 | G, K (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | H, L (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A, B: 1 - 440 (UniProt: P16586)
A, B: 441 - 800 (UniProt: Q28156)
C, D: 1 - 87 (UniProt: P04972)
A, B: 441 - 800 (UniProt: Q28156)
C, D: 1 - 87 (UniProt: P04972)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 207143.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1819.0 | |
| All* | Total formula weight | 208962.0 |
