10OU

FGFR2 mutant D650V with compound 12

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 2	polymer	324	37126.7	2	UniProt (P21802) Pfam (PF07714)	Homo sapiens (human)	FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor
2	C, Y (A, B)	N-[(3M)-3-{2-[(1-ethyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1-methyl-1H-indol-6-yl]propanamide	non-polymer		389.5	2	Chemie (A1C67)
3	AA, D, F, G, H... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	22	Chemie (EDO)
4	BA, CA, DA, E, EA... (B, A)	GLYCEROL	non-polymer		92.1	12	Chemie (GOL) PubChem (753)
5	IA, JA, KA, L, LA... (B, A)	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
6	VA, WA (A, B)	water	water		18.0	287	Chemie (HOH)

Sequence modifications

A, B: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	initiating methionine
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Val 650	Asp 650	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74253.4
Non-Polymers*	Number of molecules	45
	Total formula weight	4114.1
All*	Total formula weight	78367.5

*Water molecules are not included.