10AY

Cryo-EM structure of CRBN-DDB1 in complex with HBS1L and TNG961

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	HBS1-like protein	polymer	208	22947.0	2	UniProt (Q9Y450) Pfam (PF03144) Pfam (PF03143)	Homo sapiens (human)	ERFS
2	B, E (B, E)	Protein cereblon	polymer	404	46378.3	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
3	C, F (C, F)	DNA damage-binding protein 1	polymer	1140	127097.5	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF23726) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
4	G, I (B, E)	N-{6-[(3R)-2,6-dioxopiperidin-3-yl]naphthalen-1-yl}-N'-{2-[6-(trifluoromethyl)-1-benzothiophen-2-yl]propan-2-yl}urea	non-polymer		539.6	2	Chemie (A1C4S)
5	H, J (B, E)	ZINC ION	non-polymer		65.4	2	Chemie (ZN) PubChem (32051)

Sequence modifications

A, D: 478 - 684 (UniProt: Q9Y450)

PDB	External Database	Details
Gly 477	-	expression tag

B, E: 40 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Gly 39	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	392845.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1210.0
All*	Total formula weight	394055.5

*Water molecules are not included.