10AY

Cryo-EM structure of CRBN-DDB1 in complex with HBS1L and TNG961

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0030177	biological_process	positive regulation of Wnt signaling pathway
B	0031333	biological_process	negative regulation of protein-containing complex assembly
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
B	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
B	0035641	biological_process	locomotory exploration behavior
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044325	molecular_function	transmembrane transporter binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0060173	biological_process	limb development
C	0000109	cellular_component	nucleotide-excision repair complex
C	0000781	cellular_component	chromosome, telomeric region
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006289	biological_process	nucleotide-excision repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006974	biological_process	DNA damage response
C	0007056	biological_process	spindle assembly involved in female meiosis
C	0007283	biological_process	spermatogenesis
C	0008283	biological_process	cell population proliferation
C	0010498	biological_process	proteasomal protein catabolic process
C	0010506	biological_process	regulation of autophagy
C	0016567	biological_process	protein ubiquitination
C	0019076	biological_process	viral release from host cell
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031297	biological_process	replication fork processing
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
C	0032814	biological_process	regulation of natural killer cell activation
C	0032991	cellular_component	protein-containing complex
C	0034644	biological_process	cellular response to UV
C	0035861	cellular_component	site of double-strand break
C	0040029	biological_process	epigenetic regulation of gene expression
C	0042127	biological_process	regulation of cell population proliferation
C	0042752	biological_process	regulation of circadian rhythm
C	0042981	biological_process	regulation of apoptotic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044725	biological_process	epigenetic programming in the zygotic pronuclei
C	0044877	molecular_function	protein-containing complex binding
C	0045070	biological_process	positive regulation of viral genome replication
C	0045722	biological_process	positive regulation of gluconeogenesis
C	0045732	biological_process	positive regulation of protein catabolic process
C	0045995	biological_process	regulation of embryonic development
C	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
C	0051702	biological_process	biological process involved in interaction with symbiont
C	0060964	biological_process	regulation of miRNA-mediated gene silencing
C	0070062	cellular_component	extracellular exosome
C	0070914	biological_process	UV-damage excision repair
C	0071987	molecular_function	WD40-repeat domain binding
C	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
C	0080135	biological_process	regulation of cellular response to stress
C	0097602	molecular_function	cullin family protein binding
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1901987	biological_process	regulation of cell cycle phase transition
C	1901990	biological_process	regulation of mitotic cell cycle phase transition
C	1902412	biological_process	regulation of mitotic cytokinesis
C	1904178	biological_process	negative regulation of adipose tissue development
C	2000036	biological_process	regulation of stem cell population maintenance
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0016020	cellular_component	membrane
E	0016567	biological_process	protein ubiquitination
E	0030177	biological_process	positive regulation of Wnt signaling pathway
E	0031333	biological_process	negative regulation of protein-containing complex assembly
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
E	0035641	biological_process	locomotory exploration behavior
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044325	molecular_function	transmembrane transporter binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0060173	biological_process	limb development
F	0000109	cellular_component	nucleotide-excision repair complex
F	0000781	cellular_component	chromosome, telomeric region
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006974	biological_process	DNA damage response
F	0007056	biological_process	spindle assembly involved in female meiosis
F	0007283	biological_process	spermatogenesis
F	0008283	biological_process	cell population proliferation
F	0010498	biological_process	proteasomal protein catabolic process
F	0010506	biological_process	regulation of autophagy
F	0016567	biological_process	protein ubiquitination
F	0019076	biological_process	viral release from host cell
F	0030174	biological_process	regulation of DNA-templated DNA replication initiation
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0031297	biological_process	replication fork processing
F	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
F	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
F	0032814	biological_process	regulation of natural killer cell activation
F	0032991	cellular_component	protein-containing complex
F	0034644	biological_process	cellular response to UV
F	0035861	cellular_component	site of double-strand break
F	0040029	biological_process	epigenetic regulation of gene expression
F	0042127	biological_process	regulation of cell population proliferation
F	0042752	biological_process	regulation of circadian rhythm
F	0042981	biological_process	regulation of apoptotic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0044725	biological_process	epigenetic programming in the zygotic pronuclei
F	0044877	molecular_function	protein-containing complex binding
F	0045070	biological_process	positive regulation of viral genome replication
F	0045722	biological_process	positive regulation of gluconeogenesis
F	0045732	biological_process	positive regulation of protein catabolic process
F	0045995	biological_process	regulation of embryonic development
F	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
F	0051702	biological_process	biological process involved in interaction with symbiont
F	0060964	biological_process	regulation of miRNA-mediated gene silencing
F	0070062	cellular_component	extracellular exosome
F	0070914	biological_process	UV-damage excision repair
F	0071987	molecular_function	WD40-repeat domain binding
F	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
F	0080135	biological_process	regulation of cellular response to stress
F	0097602	molecular_function	cullin family protein binding
F	0160072	molecular_function	ubiquitin ligase complex scaffold activity
F	1901987	biological_process	regulation of cell cycle phase transition
F	1901990	biological_process	regulation of mitotic cell cycle phase transition
F	1902412	biological_process	regulation of mitotic cytokinesis
F	1904178	biological_process	negative regulation of adipose tissue development
F	2000036	biological_process	regulation of stem cell population maintenance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q69ZS7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	216
Details	Domain: {"description":"CULT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25108355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TZ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---