1HTR | |
1TZS | | CRYSTAL STRUCTURE OF AN ACTIVATION INTERMEDIATE OF CATHEPSIN E | | Descriptor: | Cathepsin E, activation peptide from Cathepsin E, 23-mer peptide from PelB-IgG kappa light chain fusion protein | | Authors: | Ostermann, N., Gerhartz, B., Worpenberg, S., Trappe, J., Eder, J. | | Deposit date: | 2004-07-12 | | Release date: | 2005-07-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal structure of an activation intermediate of cathepsin e
J.Mol.Biol., 342, 2004
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2PSG | |
2X0B | | CRYSTAL STRUCTURE OF HUMAN ANGIOTENSINOGEN COMPLEXED WITH RENIN | | Descriptor: | RENIN, ANGIOTENSINOGEN | | Authors: | Zhou, A., Wei, Z., Yan, Y., Carrell, R.W., Read, R.J. | | Deposit date: | 2009-12-08 | | Release date: | 2010-10-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (4.33 Å) | | Cite: | A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
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3PSG | |
3VCM | | CRYSTAL STRUCTURE OF HUMAN PRORENIN | | Descriptor: | prorenin, N-ACETYL-D-GLUCOSAMINE | | Authors: | Morales, R., Watier, Y., Bocskei, Z. | | Deposit date: | 2012-01-04 | | Release date: | 2012-05-23 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Human Prorenin Structure Sheds Light on a Novel Mechanism of Its Autoinhibition and on Its Non-Proteolytic Activation by the (Pro)renin Receptor.
J.Mol.Biol., 421, 2012
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4AMT | |
5MKT | |
5N7N | | CRYSTAL STRUCTURE OF CATHEPSIN D ZYMOGEN FROM THE TICK IXODES RICINUS (IRCD1) | | Descriptor: | Putative cathepsin d, SULFATE ION, AMMONIUM ION | | Authors: | Brynda, J., Hanova, I., Hobizalova, R., Mares, M. | | Deposit date: | 2017-02-21 | | Release date: | 2017-12-27 | | Last modified: | 2018-03-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite.
Cell Chem Biol, 25, 2018
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5UX4 | | CRYSTAL STRUCTURE OF RAT CATHEPSIN D WITH (5S)-3-(5,6-DIHYDRO-2H-PYRAN-3-YL)-1-FLUORO- 7-(2-FLUOROPYRIDIN-3-YL)SPIRO[CHROMENO[2,3- C]PYRIDINE-5,4'-[1,3]OXAZOL]-2'-AMINE | | Descriptor: | Cathepsin D, N-ACETYL-D-GLUCOSAMINE, (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine | | Authors: | Sickmier, A. | | Deposit date: | 2017-02-22 | | Release date: | 2018-06-13 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.805 Å) | | Cite: | Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Medchemcomm, 8, 2017
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