1K3X
 
 | | Crystal structure of a trapped reaction intermediate of the DNA repair enzyme Endonuclease VIII with Brominated-DNA | | Descriptor: | 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*(BRU)P*(BRU)P*CP*AP*(BRU)P*CP*CP*(BRU)P*GP*G)-3', Endonuclease VIII, ... | | Authors: | Golan, G, Zharkov, D.O, Gilboa, R, Fernandes, A.S, Kycia, J.H, Gerchman, S.E, Rieger, R.A, Grollman, A.P, Shoham, G. | | Deposit date: | 2001-10-04 | | Release date: | 2002-10-04 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate.
EMBO J., 21, 2002
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2EA0
 | | Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli in complex with AP-site containing DNA substrate | | Descriptor: | 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', 5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', Endonuclease VIII, ... | | Authors: | Golan, G, Zharov, D.O, Grollman, A.P, Shoham, G. | | Deposit date: | 2007-01-29 | | Release date: | 2008-02-26 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrate and mutations of critical residues
To be Published
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1K3W
 | | Crystal structure of a trapped reaction intermediate of the DNA Repair Enzyme Endonuclease VIII with DNA | | Descriptor: | 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*GP*G)-3', Endonuclease VIII, ... | | Authors: | Golan, G, Zharkov, D.O, Gilboa, R, Fernandes, A.S, Kycia, J.H, Gerchman, S.E, Rieger, R.A, Grollman, A.P, Shoham, G. | | Deposit date: | 2001-10-04 | | Release date: | 2002-10-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate.
EMBO J., 21, 2002
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8TJG
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3U6P
 | | MutM set 1 GpG | | Descriptor: | DNA (5'-D(*A*GP*GP*TP*AP*GP*AP*TP*CP*CP*CP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*GP*GP*GP*AP*(08Q)P*CP*TP*AP*CP*C)-3'), Formamidopyrimidine-DNA glycosylase, ... | | Authors: | Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L. | | Deposit date: | 2011-10-12 | | Release date: | 2012-04-25 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM.
J.Biol.Chem., 287, 2012
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3GPU
 | | MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC4-loop deletion complex | | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*(8OG)P*AP*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | | Authors: | Banerjee, A, Qi, Y, Verdine, G.L. | | Deposit date: | 2009-03-23 | | Release date: | 2009-11-10 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
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1R2Z
 | | MutM (Fpg) bound to 5,6-dihydrouracil (DHU) containing DNA | | Descriptor: | 5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*CP*GP*TP*CP*CP*AP*(DHU)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ... | | Authors: | Fromme, J.C, Verdine, G.L. | | Deposit date: | 2003-09-30 | | Release date: | 2003-10-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | DNA Lesion Recognition by the Bacterial Repair Enzyme MutM.
J.Biol.Chem., 278, 2003
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3SAU
 | | MUTM Interrogation complex 6 | | Descriptor: | 5'-D(*A*GP*GP*TP*AP*GP*AP*CP*CP*AP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*CP*GP*T*CP*CP*TP*GP*GP*(TX2) P*CP*TP*AP*CP*C)-3', DNA GLYCOSYLASE, ... | | Authors: | Spong, M.C, Qi, Y, Verdine, G.L. | | Deposit date: | 2011-06-03 | | Release date: | 2012-01-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Strandwise translocation of a DNA glycosylase on undamaged DNA.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4PD2
 | | Crystal structure of a complex between a C248GH LlFpg mutant and a THF containing DNA | | Descriptor: | DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), Formamidopyrimidine-DNA glycosylase, ... | | Authors: | Coste, F, Castaing, B. | | Deposit date: | 2014-04-17 | | Release date: | 2015-04-01 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization.
Nucleic Acids Res., 42, 2014
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3GQ4
 | | Sequence-matched MutM Lesion Recognition Complex 5 (LRC5) | | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | | Authors: | Spong, M.C, Qi, Y, Verdine, G.L. | | Deposit date: | 2009-03-23 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
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3U6E
 | | MutM set 1 TpGo | | Descriptor: | DNA (5'-D(*A*GP*GP*TP*AP*GP*AP*TP*CP*CP*AP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*TP*(8OG)P*GP*AP*(08Q)P*CP*TP*AP*CP*C)-3'), Formamidopyrimidine-DNA glycosylase, ... | | Authors: | Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L. | | Deposit date: | 2011-10-12 | | Release date: | 2012-04-25 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM.
J.Biol.Chem., 287, 2012
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4PCZ
 | | Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA | | Descriptor: | DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), Formamidopyrimidine-DNA glycosylase, ... | | Authors: | Coste, F, Castaing, B. | | Deposit date: | 2014-04-17 | | Release date: | 2015-04-01 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization.
Nucleic Acids Res., 42, 2014
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1L1Z
 | | MutM (Fpg) Covalent-DNA Intermediate | | Descriptor: | 5'-D(*AP*G*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*C*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ... | | Authors: | Fromme, J.C, Verdine, G.L. | | Deposit date: | 2002-02-20 | | Release date: | 2002-06-14 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM.
Nat.Struct.Biol., 9, 2002
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3JR5
 | | MutM lesion recognition control complex with N174C crosslinking site | | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*(OGX)P*AP*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | | Authors: | Qi, Y, Spong, M.C, Verdine, G.L. | | Deposit date: | 2009-09-08 | | Release date: | 2009-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.704 Å) | | Cite: | Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM.
J.Biol.Chem., 285, 2010
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6H0S
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6RNM
 | | Crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor | | Descriptor: | 6-azanyl-9~{H}-purine-8-thiol, DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), ... | | Authors: | Coste, F, Goffinont, S, Castaing, B. | | Deposit date: | 2019-05-09 | | Release date: | 2020-04-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights.
Int J Mol Sci, 21, 2020
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3U6S
 | | MutM set 1 TpG | | Descriptor: | DNA (5'-D(*A*GP*GP*TP*AP*GP*AP*TP*CP*CP*AP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*TP*GP*GP*AP*(08Q)P*CP*TP*AP*CP*C)-3'), Formamidopyrimidine-DNA glycosylase, ... | | Authors: | Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L. | | Deposit date: | 2011-10-12 | | Release date: | 2012-04-25 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM.
J.Biol.Chem., 287, 2012
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3GPX
 | | Sequence-matched MutM Interrogation Complex 4 (IC4) | | Descriptor: | DNA (5'-D(*A*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*AP*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | | Authors: | Spong, M.C, Qi, Y, Verdine, G.L. | | Deposit date: | 2009-03-23 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
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2XZF
 | | CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE WILD-TYPE LACTOCOCCUS LACTIS FPG (MUTM) AND AN OXIDIZED PYRIMIDINE CONTAINING DNA AT 293K | | Descriptor: | 5'-D(*CP*TP*CP*TP*TP*TP*VETP*TP*TP*TP*CP*TP*CP*GP)-3', 5'-D(*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*AP*GP*CP)-3', FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE, ... | | Authors: | LeBihan, Y.V, Izquierdo, M.A, Coste, F, Culard, F, Gehrke, T.H, Essalhi, K, Aller, P, Carrel, T, Castaing, B. | | Deposit date: | 2010-11-25 | | Release date: | 2011-10-05 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.799 Å) | | Cite: | 5-Hydroxy-5-Methylhydantoin DNA Lesion, a Molecular Trap for DNA Glycosylases
Nucleic Acids Res., 39, 2011
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3U6C
 | | MutM set 1 ApGo | | Descriptor: | DNA (5'-D(*GP*GP*TP*AP*GP*AP*TP*CP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*CP*AP*(8OG)P*GP*AP*(TX)P*CP*TP*AP*C)-3'), Formamidopyrimidine-DNA glycosylase, ... | | Authors: | Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L. | | Deposit date: | 2011-10-12 | | Release date: | 2012-04-25 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM.
J.Biol.Chem., 287, 2012
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1TDZ
 | | Crystal Structure Complex Between the Lactococcus Lactis FPG (Mutm) and a FAPY-dG Containing DNA | | Descriptor: | 5'-D(*CP*TP*CP*TP*TP*TP*(FOX)P*TP*TP*TP*CP*TP*CP*G)-3', 5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', GLYCEROL, ... | | Authors: | Coste, F, Ober, M, Carell, T, Boiteux, S, Zelwer, C, Castaing, B. | | Deposit date: | 2004-05-24 | | Release date: | 2004-09-07 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase
J.Biol.Chem., 279, 2004
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1L1T
 | | MutM (Fpg) Bound to Abasic-Site Containing DNA | | Descriptor: | 5'-D(*AP*G*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*C*GP*TP*CP*CP*AP*(HPD)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ... | | Authors: | Fromme, J.C, Verdine, G.L. | | Deposit date: | 2002-02-19 | | Release date: | 2002-06-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM.
Nat.Struct.Biol., 9, 2002
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2XZU
 | | CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE WILD-TYPE LACTOCOCCUS LACTIS FPG (MUTM) AND AN OXIDIZED PYRIMIDINE CONTAINING DNA AT 310K | | Descriptor: | 5'-D(*CP*TP*CP*TP*TP*TP*VETP*TP*TP*TP*CP*TP*CP*G)-3', 5'-D(GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*G*A)-3', FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE, ... | | Authors: | Lebihan, Y.V, Izquierdo, M.A, Coste, F, Culard, F, Gehrke, T.H, Essalhi, K, Aller, P, Carrel, T, Castaing, B. | | Deposit date: | 2010-11-29 | | Release date: | 2011-10-05 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | 5-Hydroxy-5-Methylhydantoin DNA Lesion, a Molecular Trap for DNA Glycosylases
Nucleic Acids Res., 39, 2011
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6RO2
 | | The crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor | | Descriptor: | 2-sulfanyl-1,9-dihydro-6H-purin-6-one, DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), ... | | Authors: | Coste, F, Goffinont, S, Castaing, B. | | Deposit date: | 2019-05-10 | | Release date: | 2020-04-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.821 Å) | | Cite: | Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights.
Int J Mol Sci, 21, 2020
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3GQ3
 | | MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC5-loop deletion complex | | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | | Authors: | Banerjee, A, Qi, Y, Verdine, G.L. | | Deposit date: | 2009-03-23 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
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