5MRQ
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ARABIDOPSIS THALIANA ISPD ASP262ALA MUTANT
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Schwab, A., Illarionov, B., Frank, A., Kunfermann, A., Seet, M., Bacher, A., Witschel, M., Fischer, M., Groll, M., Diederich, F.
Deposit date:2016-12-23
Release date:2017-07-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.
ACS Chem. Biol., 12, 2017
5MRP
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ARABIDOPSIS THALIANA ISPD GLU258ALA MUTANT IN COMPLEX WITH AZOLOPYRIMIDINE (2)
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 5-chloro-7-hydroxy-6-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile, ...
Authors:Schwab, A., Illarionov, B., Frank, A., Kunfermann, A., Seet, M., Bacher, A., Witschel, M., Fischer, M., Groll, M., Diederich, F.
Deposit date:2016-12-23
Release date:2017-07-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.
ACS Chem. Biol., 12, 2017
5MRO
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ARABIDOPSIS THALIANA ISPD GLU258ALA MUTANT IN COMPLEX WITH AZOLOPYRIMIDINE (1)
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, Azolopyrimidine, ...
Authors:Schwab, A., Illarionov, B., Frank, A., Kunfermann, A., Seet, M., Bacher, A., Witschel, M., Fischer, M., Groll, M., Diederich, F.
Deposit date:2016-12-23
Release date:2017-07-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.
ACS Chem. Biol., 12, 2017
5MRN
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ARABIDOPSIS THALIANA ISPD GLU258ALA MUTANT
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, POTASSIUM ION, ...
Authors:Schwab, A., Illarionov, B., Frank, A., Kunfermann, A., Seet, M., Bacher, A., Witschel, M., Fischer, M., Groll, M., Diederich, F.
Deposit date:2016-12-23
Release date:2017-07-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.
ACS Chem. Biol., 12, 2017
5MRM
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ARABIDOPSIS THALIANA ISPD IN COMPLEX WITH ISOXAZOLE (4)
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 2,4-bis(bromanyl)-6-[3-(trifluoromethyl)-1,2-oxazol-5-yl]phenol, ...
Authors:Schwab, A., Illarionov, B., Frank, A., Kunfermann, A., Seet, M., Bacher, A., Witschel, M., Fischer, M., Groll, M., Diederich, F.
Deposit date:2016-12-23
Release date:2017-07-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.
ACS Chem. Biol., 12, 2017
5HS2
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CRYSTAL STRUCTURE OF ISPD COMPLEXED WITH CTP AND MG2+ FROM BACILLUS SUBTILIS AT 1.90 ANGSTROMS RESOLUTION
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Jin, Y., Liu, Z.C., Wang, G.G.
Deposit date:2016-01-24
Release date:2016-11-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structural and functional study on the 2-C-methyl-d-erythritol-4-phosphate cytidyltransferase (IspD) from Bacillus subtilis.
Sci Rep, 6, 2016
5DDV
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CRYSTAL STRUCTURE OF ISPD FROM BACILLUS SUBTILIS AT 2.30 ANGSTROMS RESOLUTION, CRYSTAL FORM II
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Authors:Jin, Y., Liu, Z.C., Wang, G.G.
Deposit date:2015-08-25
Release date:2016-08-31
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A structural and functional study on the 2-C-methyl-d-erythritol-4-phosphate cytidyltransferase (IspD) from Bacillus subtilis.
Sci Rep, 6, 2016
5DDT
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CRYSTAL STRUCTURE OF ISPD FROM BACILLUS SUBTILIS AT 1.80 ANGSTROMS RESOLUTION, CRYSTAL FORM I
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Authors:Jin, Y., Liu, Z.C., Wang, G.G.
Deposit date:2015-08-25
Release date:2016-08-31
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A structural and functional study on the 2-C-methyl-d-erythritol-4-phosphate cytidyltransferase (IspD) from Bacillus subtilis.
Sci Rep, 6, 2016
4ZDQ
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CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (ISPD) FROM BURKHOLDERIA THAILANDENSIS COMPLEXED WITH CTP
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-04-18
Release date:2015-04-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis complexed with CTP
to be published
4YS8
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CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (ISPD) FROM BURKHOLDERIA THAILANDENSIS
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, GLYCEROL, ACETATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-03-16
Release date:2015-04-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis
to be published
4NAN
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ARABIDOPSIS THALIANA ISPD IN COMPLEX WITH TETRABROMO-PSEUDILIN
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 2-bromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NAL
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ARABIDOPSIS THALIANA ISPD IN COMPLEX WITH TRIBROMODICHLORO-PSEUDILIN
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NAK
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ARABIDOPSIS THALIANA ISPD IN COMPLEX WITH PENTABROMO-PSEUDILIN
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, PENTABROMOPSEUDILIN, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NAI
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ARABIDOPSIS THALIANA ISPD APO
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, CADMIUM ION, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
4KT7
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THE CRYSTAL STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOLSYNTHASE FROM ANAEROCOCCUS PREVOTII DSM 20548
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, CHLORIDE ION, SODIUM ION
Authors:Borek, D., Tan, K., Stols, L., Eschenfeidt, W.H., Otwinoski, Z., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-20
Release date:2013-06-05
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:The crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritolsynthase from Anaerococcus prevotii DSM 20548
To be Published
4JIS
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CRYSTAL STRUCTURE OF RIBITOL 5-PHOSPHATE CYTIDYLYLTRANSFERASE (TARI) FROM BACILLUS SUBTILIS
Descriptor:ribitol-5-phosphate cytidylyltransferase
Authors:Yang, C.S., Chen, S.C., Chen, Y.R., Kuan, S.M., Liu, Y.H., Chen, Y.
Deposit date:2013-03-06
Release date:2014-03-12
Method:X-RAY DIFFRACTION (1.772 Å)
Cite:Crystal structure of ribitol 5-phosphate cytidylyltransferase (TarI) from Bacillus subtilis
To be Published
4CVH
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CRYSTAL STRUCTURE OF HUMAN ISOPRENOID SYNTHASE DOMAIN-CONTAINING PROTEIN
Descriptor:ISOPRENOID SYNTHASE DOMAIN-CONTAINING PROTEIN, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Kopec, J., Froese, D.S., Krojer, T., Newman, J., Kiyani, W., Goubin, S., Strain-Damerell, C., Vollmar, M., von Delft, F., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Lefeber, D.J., Yue, W.W.
Deposit date:2014-03-27
Release date:2015-02-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Human Ispd is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Chem.Biol., 22, 2015
3Q80
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STRUCTURE OF MTB 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLTRANSFERASE (ISPD) COMPLEXED WITH CDP-ME
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL, MAGNESIUM ION, ...
Authors:Reddy, M.C.M., Bruning, J.B., Thurman, C., Ioerger, T.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-01-05
Release date:2011-05-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): a candidate antitubercular drug target
Proteins, 2011
3Q7U
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STRUCTURE OF MTB 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLTRANSFERASE (ISPD) COMPLEXED WITH CTP
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, MAGNESIUM ION, CYTIDINE-5'-TRIPHOSPHATE
Authors:Reddy, M.C.M., Bruning, J.B., Thurman, C., Ioerger, T.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-01-05
Release date:2011-05-04
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): a candidate antitubercular drug target
Proteins, 2011
3OKR
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STRUCTURE OF MTB APO 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLTRANSFERASE (ISPD)
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, Heptamer peptide
Authors:Sacchettini, J.C., Reddy, M.C.M., Bruning, J.B., Thurman, C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-08-25
Release date:2010-10-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): an antitubercular drug target
To be Published
3N9W
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CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (ISPD) IN COMPLEX WITH 1,2-PROPANEDIOL
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, S-1,2-PROPANEDIOL, R-1,2-PROPANEDIOL
Authors:Behnen, J., Heine, A., Klebe, G.
Deposit date:2010-05-31
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimental and computational active site mapping as a starting point to fragment-based lead discovery.
Chemmedchem, 7, 2012
3F1C
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CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE FROM LISTERIA MONOCYTOGENES
Descriptor:Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2
Authors:Patskovsky, Y., Ho, J., Toro, R., Gilmore, M., Miller, S., Groshong, C., Sauder, J.M., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-10-27
Release date:2008-11-18
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CRYSTAL STRUCTURE OF 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Listeria monocytogenes
To be Published
2YCM
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INHIBITORS OF HERBICIDAL TARGET ISPD
Descriptor:2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC, CADMIUM ION, ...
Authors:Hoeffken, H.W.
Deposit date:2011-03-16
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibitors of the Herbicidal Target Ispd: Allosteric Site Binding.
Angew.Chem.Int.Ed.Engl., 50, 2011
2YC5
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INHIBITORS OF THE HERBICIDAL TARGET ISPD
Descriptor:2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC, 5-chloro-7-hydroxy-6-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile, ...
Authors:Hoeffken, H.W.
Deposit date:2011-03-11
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibitors of the Herbicidal Target Ispd: Allosteric Site Binding.
Angew.Chem.Int.Ed.Engl., 50, 2011
2YC3
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INHIBITORS OF THE HERBICIDAL TARGET ISPD
Descriptor:2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC, 6-benzyl-5-chloro[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one, ...
Authors:Hoeffken, H.W.
Deposit date:2011-03-11
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibitors of the Herbicidal Target Ispd: Allosteric Site Binding.
Angew.Chem.Int.Ed.Engl., 50, 2011
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