1AF5
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GROUP I MOBILE INTRON ENDONUCLEASE
Descriptor:I-CREI
Authors:Heath, P.J., Stephens, K.M., Monnat Junior, R.J., Stoddard, B.L.
Deposit date:1997-03-21
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of I-Crel, a group I intron-encoded homing endonuclease.
Nat.Struct.Biol., 4, 1997
1BP7
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GROUP I MOBILE INTRON ENDONUCLEASE I-CREI COMPLEXED WITH HOMING SITE DNA
Descriptor:DNA (5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP* CP*G)-3'), DNA (5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP* GP*C)-3'), PROTEIN (I-CREI), ...
Authors:Jurica, M.S., Monnat Junior, R.J., Stoddard, B.L.
Deposit date:1998-08-13
Release date:1999-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI.
Mol.Cell, 2, 1998
1G9Y
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HOMING ENDONUCLEASE I-CREI / DNA SUBSTRATE COMPLEX WITH CALCIUM
Descriptor:5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', DNA ENDONUCLEASE I-CREI, ...
Authors:Chevalier, B., Monnat, R.J., Stoddard, B.L.
Deposit date:2000-11-28
Release date:2001-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites.
Nat.Struct.Biol., 8, 2001
1G9Z
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LAGLIDADG HOMING ENDONUCLEASE I-CREI / DNA PRODUCT COMPLEX WITH MAGNESIUM
Descriptor:5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*C)-3', ...
Authors:Chevalier, B., Monnat, R.J., Stoddard, B.L.
Deposit date:2000-11-28
Release date:2001-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites.
Nat.Struct.Biol., 8, 2001
1M5X
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-MSOI BOUND TO ITS DNA SUBSTRATE
Descriptor:5'-D(*GP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*CP*TP*GP*C)-3', DNA endonuclease I-MsoI, ...
Authors:Chevalier, B., Turmel, M., Lemieux, C., Monnat, R.J., Stoddard, B.L.
Deposit date:2002-07-10
Release date:2003-06-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
J.Mol.Biol., 329, 2003
1N3E
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CRYSTAL STRUCTURE OF I-CREI BOUND TO A PALINDROMIC DNA SEQUENCE I (PALINDROME OF LEFT SIDE OF WILDTYPE DNA TARGET SEQUENCE)
Descriptor:5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3', 5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA endonuclease I-CreI, ...
Authors:Chevalier, B., Turmel, M., Lemieux, C., Monnat, R.J., Stoddard, B.L.
Deposit date:2002-10-28
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
J.Mol.Biol., 329, 2003
1N3F
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CRYSTAL STRUCTURE OF I-CREI BOUND TO A PALINDROMIC DNA SEQUENCE II (PALINDROME OF RIGHT SIDE OF WILDTYPE DNA TARGET SEQUENCE)
Descriptor:5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G-3'), DNA endonuclease I-CreI, ...
Authors:Chevalier, B., Turmel, M., Lemieux, C., Monnat, R.J., Stoddard, B.L.
Deposit date:2002-10-28
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
J.Mol.Biol., 329, 2003
1P8K
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THE STRUCTURE AND DNA RECOGNITION OF A BIFUNCTIONAL HOMING ENDONUCLEASE AND GROUP I INTRON SPLICING FACTOR
Descriptor:5'-D(P*GP*CP*GP*CP*GP*CP*TP*GP*AP*GP*GP*AP*GP*GP*TP*TP*TP*C)-3', 5'-D(P*TP*CP*TP*GP*TP*AP*AP*AP*GP*CP*GP*CP*A)-3', 5'-D(P*GP*CP*GP*CP*TP*TP*TP*AP*CP*AP*GP*AP*GP*AP*AP*A)-3', ...
Authors:Stoddard, B.L., Bolduc, J.M.
Deposit date:2003-05-07
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor.
Genes Dev., 17, 2003
1T9I
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I-CREI(D20N)/DNA COMPLEX
Descriptor:5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', DNA endonuclease I-CreI, ...
Authors:Chevalier, B., Sussman, D., Otis, C., Boudreau, D., Turmel, M., Lemieux, C., Stephens, K., Monnat Jr., R.J., Stoddard, B.L.
Deposit date:2004-05-17
Release date:2004-11-16
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Metal-Dependent DNA Cleavage Mechanism of the I-CreI LAGLIDADG Homing Endonuclease.
Biochemistry, 43, 2004
1T9J
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I-CREI(Q47E)/DNA COMPLEX
Descriptor:5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', DNA endonuclease I-CreI
Authors:Chevalier, B., Sussman, D., Otis, C., Boudreau, D., Turmel, M., Lemieux, C., Stephens, K., Monnat Jr., R.J., Stoddard, B.L.
Deposit date:2004-05-17
Release date:2004-11-16
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Metal-Dependent DNA Cleavage Mechanism of the I-CreI LAGLIDADG Homing Endonuclease.
Biochemistry, 43, 2004
1U0C
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Y33C MUTANT OF HOMING ENDONUCLEASE I-CREI
Descriptor:5'-D(*GP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*AP*CP*G)-3', 5'-D(*CP*GP*TP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*AP*GP*C)-3', DNA endonuclease I-CreI, ...
Authors:Sussman, D., Chadsey, M., Fauce, S., Engel, A., Bruett, A., Monnat, R., Stoddard, B.L., Seligman, L.M.
Deposit date:2004-07-13
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Isolation and characterization of new homing endonuclease specificities at individual target site positions.
J.Mol.Biol., 342, 2004
1U0D
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Y33H MUTANT OF HOMING ENDONUCLEASE I-CREI
Descriptor:5'-D(*GP*CP*GP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*CP*GP*C)-3', DNA endonuclease I-CreI
Authors:Sussman, D., Chadsey, M., Fauce, S., Engel, A., Bruett, A., Monnat, R., Stoddard, B.L., Seligman, L.M.
Deposit date:2004-07-13
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Isolation and characterization of new homing endonuclease specificities at individual target site positions.
J.Mol.Biol., 342, 2004
2AB5
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BI3 LAGLIDADG MATURASE
Descriptor:mRNA maturase, SULFATE ION
Authors:Longo, A., Leonard, C.W., Bassi, G.S., Berndt, D., Krahn, J.M., Hall, T.M., Weeks, K.M.
Deposit date:2005-07-14
Release date:2005-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase
Nat.Struct.Mol.Biol., 12, 2005
2EX5
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GROUP I INTRON-ENCODED HOMING ENDONUCLEASE I-CEUI COMPLEXED WITH DNA
Descriptor:I-CeuI DNA target site, complimentary strand, DNA endonuclease I-CeuI, ...
Authors:Spiegel, P.C., Stoddard, B.L.
Deposit date:2005-11-07
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold.
Structure, 14, 2006
2FLD
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY
Descriptor:5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', DNA ENDONUCLEASE I-MSOI, ...
Authors:Ashworth, J., Duarte, C.M., Havranek, J.J., Sussman, D., Monnat, R.J., Stoddard, B.L., Baker, D.
Deposit date:2006-01-05
Release date:2006-06-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computational redesign of endonuclease DNA binding and cleavage specificity.
Nature, 441, 2006
2I3P
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K28R MUTANT OF HOMING ENDONUCLEASE I-CREI
Descriptor:5'-D(*GP*CP*AP*AP*AP*TP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*AP*TP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*AP*TP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*AP*TP*TP*TP*GP*C)-3', DNA endonuclease I-CreI, ...
Authors:Sussman, D., Rosen, L.
Deposit date:2006-08-20
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Homing endonuclease I-CreI derivatives with novel DNA target specificities.
Nucleic Acids Res., 34, 2006
2I3Q
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Q44V MUTANT OF HOMING ENDONUCLEASE I-CREI
Descriptor:5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*AP*CP*GP*TP*GP*AP*GP*TP*CP*AP*GP*TP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*AP*CP*TP*CP*AP*CP*GP*TP*CP*GP*TP*TP*TP*TP*GP*C)-3', DNA endonuclease I-CreI, ...
Authors:Rosen, L., Sussman, D.
Deposit date:2006-08-20
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Homing endonuclease I-CreI derivatives with novel DNA target specificities.
Nucleic Acids Res., 34, 2006
2O7M
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THE C-TERMINAL LOOP OF THE HOMING ENDONUCLEASE I-CREI IS ESSENTIAL FOR DNA BINDING AND CLEAVAGE. IDENTIFICATION OF A NOVEL SITE FOR SPECIFICITY ENGINEERING IN THE I-CREI SCAFFOLD
Descriptor:DNA endonuclease I-CreI
Authors:Prieto, J., Redondo, P., Padro, D., Blanco, F.J., Paques, F., Montoya, G.
Deposit date:2006-12-11
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage
Nucleic Acids Res., 35, 2007
2QOJ
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COEVOLUTION OF A HOMING ENDONUCLEASE AND ITS HOST TARGET SEQUENCE
Descriptor:Intron-encoded DNA endonuclease I-AniI, I-AniI DNA target seq1, I-AniI DNA target seq2, ...
Authors:Scalley-Kim, M., McConnell Smith, A., Stoddard, B.L.
Deposit date:2007-07-20
Release date:2008-11-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Coevolution of a homing endonuclease and its host target sequence.
J.Mol.Biol., 372, 2007
2VBJ
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBL
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*DT*DC*DT*DG*DC*DC*DT*DT*DT*DT*DT*DT *DGP*DAP)-3', 5'-D(*DT*DT*DA*DG*DG*DA*DT*DC*DC*DT*DT*DC *DAP*DAP)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBN
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP)-3', 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBO
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
3E54
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ARCHAEAL INTRON-ENCODED HOMING ENDONUCLEASE I-VDI141I COMPLEXED WITH DNA
Descriptor:RRNA intron-encoded endonuclease, DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DTP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(P*DGP*DGP*DTP*DAP*DGP*DCP*DCP*DAP*DA)-3'), ...
Authors:Nomura, N., Nomura, Y., Sussman, D., Stoddard, B.L.
Deposit date:2008-08-13
Release date:2008-12-30
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases
Nucleic Acids Res., 36, 2008
3EH8
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CRYSTAL STRUCTURE OF Y2 I-ANII VARIANT (F13Y/S111Y)/DNA COMPLEX WITH CALCIUM
Descriptor:Intron-encoded DNA endonuclease I-AniI, 31-MER, CALCIUM ION
Authors:Takeuchi, R., Stoddard, B.L.
Deposit date:2008-09-11
Release date:2009-01-13
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.
Nucleic Acids Res., 37, 2009
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