Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

9CHQ
DownloadVisualize
BU of 9chq by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 3 mM K+
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I.
Deposit date:2024-07-01
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Nat Commun, 15, 2024
9CHS
DownloadVisualize
BU of 9chs by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 3 mM K+ without symmetry
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I.
Deposit date:2024-07-01
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Nat Commun, 15, 2024
9CHP
DownloadVisualize
BU of 9chp by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I.
Deposit date:2024-07-01
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Nat Commun, 15, 2024
9CHR
DownloadVisualize
BU of 9chr by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ without symmetry
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I.
Deposit date:2024-07-01
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Nat Commun, 15, 2024
9C49
DownloadVisualize
BU of 9c49 by Molmil
Cryo-EM structure of Danio rerio voltage-sensing phosphatase (VSP) phosphatase domain
Descriptor: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2
Authors:Zhang, L, Brohawn, S.G.
Deposit date:2024-06-03
Release date:2024-07-10
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Coupling sensor to enzyme in the voltage sensing phosphatase.
Nat Commun, 15, 2024
8Z3S
DownloadVisualize
BU of 8z3s by Molmil
Activation mechanism and novel binding site of the BKCa channel activator CTIBD
Descriptor: 4-[4-(4-chlorophenyl)-3-(trifluoromethyl)-1,2-oxazol-5-yl]benzene-1,3-diol, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Lee, N, Kim, S, Jo, H, Lee, N.Y, Jin, M.S, Park, C.S.
Deposit date:2024-04-16
Release date:2024-07-31
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Activation mechanism and novel binding sites of the BK Ca channel activator CTIBD.
Life Sci Alliance, 7, 2024
9BC7
DownloadVisualize
BU of 9bc7 by Molmil
HCN1 M305L holo
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Kim, E.D, Nimigean, C.M.
Deposit date:2024-04-08
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
9BC6
DownloadVisualize
BU of 9bc6 by Molmil
HCN1 M305L with propofol
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Kim, E.D, Nimigean, C.M.
Deposit date:2024-04-07
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
9B94
DownloadVisualize
BU of 9b94 by Molmil
Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-22
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B91
DownloadVisualize
BU of 9b91 by Molmil
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and ATP at 37 degrees Celsius
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B90
DownloadVisualize
BU of 9b90 by Molmil
Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B93
DownloadVisualize
BU of 9b93 by Molmil
Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius
Descriptor: Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8Z
DownloadVisualize
BU of 9b8z by Molmil
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and decavanadate at 37 degrees Celsius
Descriptor: CALCIUM ION, DECAVANADATE, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B92
DownloadVisualize
BU of 9b92 by Molmil
Cryo-EM structure of the human TRPM4 in complex with calcium at 18 degrees Celsius
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8W
DownloadVisualize
BU of 9b8w by Molmil
Cryo-EM structure of the human TRPM4 in complex with calcium at 37 degrees Celsius
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8X
DownloadVisualize
BU of 9b8x by Molmil
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8Y
DownloadVisualize
BU of 9b8y by Molmil
Cryo-EM structure of the human TRPM4 channel in complex with calcium and decavanadate at 37 degrees Celsius
Descriptor: CALCIUM ION, DECAVANADATE, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B6H
DownloadVisualize
BU of 9b6h by Molmil
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ...
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9B6D
DownloadVisualize
BU of 9b6d by Molmil
Cryo-EM structure of the mouse TRPM8 channel in the ligand-free desensitized state
Descriptor: CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9B6G
DownloadVisualize
BU of 9b6g by Molmil
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ...
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9B6F
DownloadVisualize
BU of 9b6f by Molmil
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850
Descriptor: (8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9B6E
DownloadVisualize
BU of 9b6e by Molmil
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014
Descriptor: 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9B6J
DownloadVisualize
BU of 9b6j by Molmil
Cryo-EM structure of the mouse TRPM8 channel in complex with PI(4,5)P2 and Ca2+
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9B6K
DownloadVisualize
BU of 9b6k by Molmil
Cryo-EM structure of the mouse TRPM8 channel in complex with Ca2+ in the absence of PI(4,5)P2
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9AYK
DownloadVisualize
BU of 9ayk by Molmil
Cryo-EM structure of human Cav3.2 with ML218
Descriptor: 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-{[(1R,5S,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2024-03-08
Release date:2024-04-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 34, 2024

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon