8PIU
| 60-meric complex of dihydrolipoamide acetyltransferase (E2) of the human pyruvate dehydrogenase complex | Descriptor: | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | Authors: | Zdanowicz, R, Afanasyev, P, Boehringer, D, Glockshuber, R. | Deposit date: | 2023-06-22 | Release date: | 2024-07-10 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Stoichiometry and architecture of the human pyruvate dehydrogenase complex. Sci Adv, 10, 2024
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8P5X
| Single particle cryo-EM structure of the complex between Corynebacterium glutamicum homohexameric 2-oxoglutarate dehydrogenase OdhA and the FHA-protein inhibitor OdhI | Descriptor: | 2-oxoglutarate dehydrogenase E1/E2 component, MAGNESIUM ION, Oxoglutarate dehydrogenase inhibitor, ... | Authors: | Yang, L, Mechaly, A.M, Bellinzoni, M. | Deposit date: | 2023-05-24 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.29 Å) | Cite: | High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase. Nat Commun, 14, 2023
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8P5W
| Single particle cryo-EM structure of homohexameric 2-oxoglutarate dehydrogenase OdhA from Corynebacterium glutamicum following reaction with the 2-oxoglutarate analogue succinyl phosphonate | Descriptor: | (4~{S})-4-[(2~{R})-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-2~{H}-1,3-thiazol-2-yl]-4-oxidanyl-4-phosphono-butanoic acid, 2-oxoglutarate dehydrogenase E1/E2 component, ACETYL COENZYME *A, ... | Authors: | Yang, L, Mechaly, A.M, Bellinzoni, M. | Deposit date: | 2023-05-24 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.26 Å) | Cite: | High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase. Nat Commun, 14, 2023
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8P5V
| Single particle cryo-EM structure of homohexameric 2-oxoglutarate dehydrogenase OdhA from Corynebacterium glutamicum in complex with the product succinyl-CoA | Descriptor: | 2-oxoglutarate dehydrogenase E1/E2 component, ACETYL COENZYME *A, MAGNESIUM ION, ... | Authors: | Yang, L, Mechaly, A.M, Bellinzoni, M. | Deposit date: | 2023-05-24 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.07 Å) | Cite: | High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase. Nat Commun, 14, 2023
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8P5U
| Single particle cryo-EM structure of homohexameric 2-oxoglutarate dehydrogenase OdhA from Corynebacterium glutamicum with Coenzyme A bound to the E2o domain | Descriptor: | 2-oxoglutarate dehydrogenase E1/E2 component, ACETYL COENZYME *A, COENZYME A, ... | Authors: | Yang, L, Mechaly, A.M, Bellinzoni, M. | Deposit date: | 2023-05-24 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.17 Å) | Cite: | High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase. Nat Commun, 14, 2023
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8P5T
| Single particle cryo-EM structure of the homohexameric 2-oxoglutarate dehydrogenase OdhA from Corynebacterium glutamicum | Descriptor: | 2-oxoglutarate dehydrogenase E1/E2 component, ACETYL COENZYME *A, MAGNESIUM ION, ... | Authors: | Yang, L, Mechaly, A.M, Bellinzoni, M. | Deposit date: | 2023-05-24 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.17 Å) | Cite: | High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase. Nat Commun, 14, 2023
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8P5S
| Crystal structure of the homohexameric 2-oxoglutarate dehydrogenase OdhA from Corynebacterium glutamicum | Descriptor: | 2-oxoglutarate dehydrogenase E1/E2 component, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETYL COENZYME *A, ... | Authors: | Yang, L, Boyko, A, Bellinzoni, M. | Deposit date: | 2023-05-24 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.459 Å) | Cite: | High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase. Nat Commun, 14, 2023
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8P5R
| Crystal structure of full-length, homohexameric 2-oxoglutarate dehydrogenase KGD from Mycobacterium smegmatis in complex with GarA | Descriptor: | CALCIUM ION, Glycogen accumulation regulator GarA, MAGNESIUM ION, ... | Authors: | Wagner, T, Mechaly, A.M, Alzari, P.M, Bellinzoni, M. | Deposit date: | 2023-05-24 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (4.562 Å) | Cite: | High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase. Nat Commun, 14, 2023
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8OSY
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8ORB
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8OIU
| Cryo-EM reconstruction of the native 24-mer E2o core of the 2-oxoglutarate dehydrogenase complex of C. thermophilum at 3.35 A resolution | Descriptor: | Dihydrolipoyllysine-residue succinyltransferase | Authors: | Skalidis, I, Tueting, C, Kyrilis, F.L, Hamdi, F, Kastritis, P.L. | Deposit date: | 2023-03-23 | Release date: | 2023-05-31 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon. Commun Biol, 6, 2023
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8OHS
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7UOL
| Endogenous dihydrolipoamide succinyltransferase (E2) core of 2-oxoglutarate dehydrogenase complex from bovine kidney | Descriptor: | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | Authors: | Liu, S, Xia, X, Zhen, J, Li, Z.H, Zhou, Z.H. | Deposit date: | 2022-04-13 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney. Cell Discov, 8, 2022
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7R5M
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7Q5R
| Protein community member pyruvate dehydrogenase complex E2 core from C. thermophilum | Descriptor: | Acetyltransferase component of pyruvate dehydrogenase complex | Authors: | Chojnowski, G, Skalidis, I, Kyrilis, F.L, Tueting, C, Hamdi, F, Kastritis, P.L. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Cryo-EM and artificial intelligence visualize endogenous protein community members. Structure, 30, 2022
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7Q5Q
| Protein community member oxoglutarate dehydrogenase complex E2 core from C. thermophilum | Descriptor: | Dihydrolipoyllysine-residue succinyltransferase | Authors: | Chojnowski, G, Skalidis, I, Kyrilis, F.L, Tueting, C, Hamdi, F, Kastritis, P.L. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4.38 Å) | Cite: | Cryo-EM and artificial intelligence visualize endogenous protein community members. Structure, 30, 2022
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7OTT
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7BGJ
| C. thermophilum Pyruvate Dehydrogenase Complex Core | Descriptor: | Acetyltransferase component of pyruvate dehydrogenase complex | Authors: | Tueting, C, Kastritis, P.L. | Deposit date: | 2021-01-07 | Release date: | 2021-02-10 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts. Cell Rep, 34, 2021
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7B9K
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6ZZN
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6ZZM
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6ZZL
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6ZZK
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6ZZJ
| Crystal structure of the catalytic domain of Corynebacterium glutamicum acetyltransferase AceF (E2p) in complex with oxidized CoA. | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, OXIDIZED COENZYME A | Authors: | Bruch, E.M, Lexa-Sapart, N, Bellinzoni, M. | Deposit date: | 2020-08-04 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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6ZZI
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