1UNQ
| High resolution crystal structure of the Pleckstrin Homology Domain Of Protein Kinase B/Akt Bound To Ins(1,3,4,5)-Tetrakisphophate | Descriptor: | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-ALPHA SERINE/THREONINE KINASE | Authors: | Milburn, C.C, Deak, M, Kelly, S.M, Price, N.C, Alessi, D.R, van Aalten, D.M.F. | Deposit date: | 2003-09-12 | Release date: | 2004-09-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (0.98 Å) | Cite: | Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem. J., 375, 2003
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3AJ4
| Crystal structure of the PH domain of Evectin-2 from human complexed with O-phospho-L-serine | Descriptor: | 1,2-ETHANEDIOL, PHOSPHOSERINE, Pleckstrin homology domain-containing family B member 2 | Authors: | Okazaki, S, Kato, R, Wakatsuki, S. | Deposit date: | 2010-05-21 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes Proc.Natl.Acad.Sci.USA, 108, 2011
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5MR1
| Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1) | Descriptor: | Interactor protein for cytohesin exchange factors 1 | Authors: | Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N, Williams, E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2016-12-21 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1) To be published
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1UNR
| Crystal structure of the PH domain of PKB alpha in complex with a sulfate molecule | Descriptor: | RAC-ALPHA SERINE/THREONINE KINASE, SULFATE ION | Authors: | Milburn, C.C, Deak, M, Kelly, S.M, Price, N.C, Alessi, D.R, van Aalten, D.M.F. | Deposit date: | 2003-09-15 | Release date: | 2004-09-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem. J., 375, 2003
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2I5F
| Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,5,6)P5 | Descriptor: | (1R,2R,3R,4R,5S,6S)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL PENTAKIS[DIHYDROGEN (PHOSPHATE)], Pleckstrin | Authors: | Jackson, S.G, Haslam, R.J, Junop, M.S. | Deposit date: | 2006-08-24 | Release date: | 2007-08-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate. Bmc Struct.Biol., 7, 2007
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6TT2
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7MYX
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1H10
| HIGH RESOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PROTEIN KINASE B/AKT BOUND TO INS(1,3,4,5)-TETRAKISPHOPHATE | Descriptor: | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-ALPHA SERINE/THREONINE KINASE | Authors: | Thomas, C.C, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | Deposit date: | 2002-07-01 | Release date: | 2003-06-27 | Last modified: | 2019-05-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | High Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate Curr.Biol., 12, 2002
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1EAZ
| Crystal structure of the phosphoinositol (3,4)-bisphosphate binding PH domain of TAPP1 from human. | Descriptor: | CITRIC ACID, TANDEM PH DOMAIN CONTAINING PROTEIN-1 | Authors: | Thomas, C.C, Dowler, S, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | Deposit date: | 2001-07-17 | Release date: | 2002-07-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal Structure of the Phosphatidylinositol 3,4-Bisphosphate-Binding Pleckstrin Homology (Ph) Domain of Tandem Ph-Domain-Containing Protein 1 (Tapp1): Molecular Basis of Lipid Specificity Biochem.J., 358, 2001
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6TSE
| Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C | Descriptor: | 1-methylindole-2,3-dione, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... | Authors: | Brear, P, Wagstaff, J, Hyvonen, M. | Deposit date: | 2019-12-20 | Release date: | 2020-11-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
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3PP2
| Crystal structure of the pleckstrin homology domain of ArhGAP27 | Descriptor: | CITRIC ACID, GLYCEROL, Rho GTPase-activating protein 27, ... | Authors: | Shen, L, Tempel, W, Tong, Y, Nedyalkova, L, Li, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-11-23 | Release date: | 2010-12-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.421 Å) | Cite: | Crystal structure of the pleckstrin homology domain of ArhGAP27 to be published
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4A6H
| Crystal structure of Slm1-PH domain in complex with Inositol-4- phosphate | Descriptor: | D-MYO-INOSITOL-4-PHOSPHATE, PHOSPHATE ION, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1 | Authors: | Anand, K, Maeda, K, Gavin, A.C. | Deposit date: | 2011-11-03 | Release date: | 2012-06-13 | Last modified: | 2015-03-25 | Method: | X-RAY DIFFRACTION (1.449 Å) | Cite: | Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site Plos One, 7, 2012
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7KJO
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2X18
| The crystal structure of the PH domain of human AKT3 protein kinase | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE | Authors: | Vollmar, M, Wang, J, Zhang, Y, Elkins, J.M, Burgess-Brown, N, Chaikuad, A, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S. | Deposit date: | 2009-12-22 | Release date: | 2010-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | The Crystal Structure of the Ph Domain of Human Akt3 Protein Kinase To be Published
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1UPQ
| Crystal structure of the pleckstrin homology (PH) domain of PEPP1 | Descriptor: | PEPP1, SULFATE ION | Authors: | Milburn, C.C, Komander, D, Deak, M, Alessi, D.R, van Aalten, D.M.F. | Deposit date: | 2003-10-09 | Release date: | 2004-10-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Crystal Structure of the Pleckstrin Homology Domain of Pepp1 To be Published
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1FGY
| GRP1 PH DOMAIN WITH INS(1,3,4,5)P4 | Descriptor: | GRP1, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | Authors: | Lietzke, S.E, Bose, S, Cronin, T, Klarlund, J, Chawla, A, Czech, M.P, Lambright, D.G. | Deposit date: | 2000-07-29 | Release date: | 2000-08-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol.Cell, 6, 2000
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1BTK
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5C79
| PH domain of ASAP1 in complex with diC4-PtdIns(4,5)P2 | Descriptor: | (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, Arf-GAP, CHLORIDE ION | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2015-06-24 | Release date: | 2015-10-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1. Structure, 23, 2015
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4KVG
| Crystal structure of RIAM RA-PH domains in complex with GTP bound Rap1 | Descriptor: | 1,2-ETHANEDIOL, Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, H, Chang, Y.E, Brennan, M.L, Wu, J. | Deposit date: | 2013-05-22 | Release date: | 2014-03-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism. J Mol Cell Biol, 6, 2014
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1UNP
| Crystal structure of the pleckstrin homology domain of PKB alpha | Descriptor: | RAC-ALPHA SERINE/THREONINE KINASE | Authors: | Milburn, C.C, Deak, M, Kelly, S.M, Price, N.C, Alessi, D.R, van Aalten, D.M.F. | Deposit date: | 2003-09-12 | Release date: | 2004-09-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem. J., 375, 2003
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4A6F
| Crystal structure of Slm1-PH domain in complex with Phosphoserine | Descriptor: | PHOSPHATE ION, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1, PHOSPHOSERINE | Authors: | Anand, K, Maeda, K, Gavin, A.C. | Deposit date: | 2011-11-02 | Release date: | 2012-06-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site Plos One, 7, 2012
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4Y93
| Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk) | Descriptor: | 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, CALCIUM ION, Non-specific protein-tyrosine kinase,Non-specific protein-tyrosine kinase, ... | Authors: | Wang, Q, Kuriyan, J. | Deposit date: | 2015-02-16 | Release date: | 2015-03-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.695 Å) | Cite: | Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
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1NTY
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1U5D
| Crystal Structure of the PH domain of SKAP55 | Descriptor: | SULFATE ION, Src Kinase-associated Phosphoprotein of 55 kDa | Authors: | Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J. | Deposit date: | 2004-07-27 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis for the Dimerization and Phosphoinositide Specificity of the Src Kinase-associated Phosphoproteins SKAP55 and SKAP-Hom To be Published
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2DTC
| Crystal structure of MS0666 | Descriptor: | RAL GUANINE NUCLEOTIDE EXCHANGE FACTOR RALGPS1A | Authors: | Wang, H, Kishishita, S, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-07-12 | Release date: | 2007-01-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of MS0666 To be Published
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