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8U7J
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BU of 8u7j by Molmil
Crystal Structure of Staphylococcus aureus PLP synthase complex
Descriptor: GLUTAMINE, PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PdxS, ...
Authors:Barra, A.L.C, Brognaro, H, Betzel, C, Nascimento, A.S.
Deposit date:2023-09-15
Release date:2024-07-24
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structure and dynamics of the staphylococcal pyridoxal 5-phosphate synthase complex reveal transient interactions at the enzyme interface.
J.Biol.Chem., 300, 2024
8SBR
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BU of 8sbr by Molmil
E coli. CTP synthase in complex with CTP (sodium malonate + 20 mM MgCl2)
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MALONIC ACID
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-04-04
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8I9O
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BU of 8i9o by Molmil
ecCTPS filament bound with CTP, NADH, DON
Descriptor: 5-OXO-L-NORLEUCINE, ADENINE, CTP synthase, ...
Authors:Guo, C.J, Liu, J.L.
Deposit date:2023-02-07
Release date:2024-02-14
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Filamentation and inhibition of prokaryotic CTP synthase with ligands.
Mlife, 3, 2024
8I0I
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BU of 8i0i by Molmil
dmCTPS with dATP dUTP dGTP and DON
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CTP synthase, DEOXYURIDINE-5'-TRIPHOSPHATE, ...
Authors:Guo, C.J, Liu, J.L.
Deposit date:2023-01-11
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of bifunctional CTP/dCTP synthase
Biorxiv, 2023
8I0H
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BU of 8i0h by Molmil
Closed conformation of CTPS with dATP dUTP dGTP and DON
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CTP synthase, ...
Authors:Liu, J.L, Guo, C.J.
Deposit date:2023-01-11
Release date:2024-07-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of bifunctional CTP/dCTP synthase
To Be Published
8HX9
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Crystal structure of 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae with chorismate
Descriptor: (3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid, 4-amino-4-deoxychorismate synthase, FORMIC ACID, ...
Authors:Nakamichi, Y, Watanabe, M.
Deposit date:2023-01-04
Release date:2023-10-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase.
Acta Crystallogr D Struct Biol, 79, 2023
8HX8
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BU of 8hx8 by Molmil
Crystal structure of 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae co-crystallized with chorismate
Descriptor: 4-amino-4-deoxychorismate synthase, MAGNESIUM ION, SUCCINIC ACID, ...
Authors:Nakamichi, Y, Watanabe, M.
Deposit date:2023-01-04
Release date:2023-10-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase.
Acta Crystallogr D Struct Biol, 79, 2023
8HX7
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BU of 8hx7 by Molmil
Crystal structure of 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae co-crystallized with L-glutamine
Descriptor: 4-amino-4-deoxychorismate synthase, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Nakamichi, Y, Watanabe, M.
Deposit date:2023-01-04
Release date:2023-10-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase.
Acta Crystallogr D Struct Biol, 79, 2023
8HX6
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BU of 8hx6 by Molmil
Crystal structure of 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae
Descriptor: 4-amino-4-deoxychorismate synthase, D-MALATE, MAGNESIUM ION, ...
Authors:Nakamichi, Y, Watanabe, M.
Deposit date:2023-01-04
Release date:2023-10-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase.
Acta Crystallogr D Struct Biol, 79, 2023
8GR3
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BU of 8gr3 by Molmil
Crystal structure of K151L/Y158F mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
Descriptor: GMP synthase [glutamine-hydrolyzing] subunit A, SULFATE ION
Authors:Chandrashekarmath, A, Bellur, A.
Deposit date:2022-08-31
Release date:2023-07-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of K151L/Y158F mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
To Be Published
8GR1
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BU of 8gr1 by Molmil
Crystal structure of D110V/K151L mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
Descriptor: GMP synthase [glutamine-hydrolyzing] subunit A, SULFATE ION
Authors:Chandrashekarmath, A, Bellur, A.
Deposit date:2022-08-31
Release date:2023-07-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of D110V/K151L mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
To Be Published
8FVE
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BU of 8fve by Molmil
E coli. CTP synthase in complex with CTP (potassium malonate + 100 mM MgCl2)
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FVD
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BU of 8fvd by Molmil
E coli. CTP synthase in complex with dF-dCTP (potassium malonate + 100 mM MgCl2)
Descriptor: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CTP synthase, MAGNESIUM ION, ...
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FVC
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BU of 8fvc by Molmil
E coli. CTP synthase in complex with dF-dCTP (potassium malonate + 5 mM MgCl2)
Descriptor: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CTP synthase, MALONIC ACID
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FVB
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BU of 8fvb by Molmil
E coli. CTP synthase in complex with CTP
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MALONIC ACID
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FVA
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BU of 8fva by Molmil
E coli. CTP synthase in complex with F-araCTP
Descriptor: 4-amino-1-{2-deoxy-2-fluoro-5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, CTP synthase, MALONIC ACID, ...
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FV9
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BU of 8fv9 by Molmil
E coli. CTP synthase in complex with F-dCTP
Descriptor: 2'-deoxy-2'-fluorocytidine 5'-(tetrahydrogen triphosphate), CTP synthase, MALONIC ACID
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FV8
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BU of 8fv8 by Molmil
E coli. CTP synthase in complex with dF-dCTP + ADP
Descriptor: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ...
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FV7
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BU of 8fv7 by Molmil
E coli. CTP synthase in complex with dF-dCTP + ATP
Descriptor: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, ...
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
8FV6
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BU of 8fv6 by Molmil
E coli. CTP synthase in complex with dF-dCTP
Descriptor: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CTP synthase, MALONIC ACID, ...
Authors:Holyoak, T, McLeod, M.J, Tran, N.
Deposit date:2023-01-18
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
7ZU9
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BU of 7zu9 by Molmil
CRYSTAL STRUCTURE OF THE C89A_C113A GMP SYNTHETASE INACTIVE DOUBLE MUTANT FROM PLASMODIUM FALCIPARUM
Descriptor: Glutamine amidotransferase
Authors:Ballut, L, Violot, S, Aghajari, N.
Deposit date:2022-05-11
Release date:2022-08-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis.
Biomolecules, 12, 2022
7YC6
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BU of 7yc6 by Molmil
Crystal structure of D110P mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
Descriptor: GMP synthase [glutamine-hydrolyzing] subunit A, ZINC ION
Authors:Chandrashekarmath, A, Bellur, A.
Deposit date:2022-06-30
Release date:2023-06-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of D110P mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
To Be Published
7WJ4
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BU of 7wj4 by Molmil
Structural basis for ligand binding modes of CTP synthase
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, GAMMA-L-GLUTAMIC ACID, ...
Authors:Liu, J.L, Guo, C.J.
Deposit date:2022-01-05
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural basis for ligand binding modes of CTP synthase.
Proc.Natl.Acad.Sci.USA, 118, 2021
7WIZ
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BU of 7wiz by Molmil
Structural basis for ligand binding modes of CTP synthase
Descriptor: CTP synthase, GLUTAMINE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Liu, J.L, Guo, C.J.
Deposit date:2022-01-05
Release date:2023-01-11
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for ligand binding modes of CTP synthase.
Proc.Natl.Acad.Sci.USA, 118, 2021
7SBC
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BU of 7sbc by Molmil
Crystal structure of a GMP synthase from Acinetobacter baumannii AB5075-UW
Descriptor: CHLORIDE ION, GMP synthase [glutamine-hydrolyzing], MAGNESIUM ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-09-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of a GMP synthase from Acinetobacter baumannii AB5075-UW
To Be Published

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PDB entries from 2024-09-18

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