8FVE

E coli. CTP synthase in complex with CTP (potassium malonate + 100 mM MgCl2)

Summary for 8FVE

• Entry DOI: 10.2210/pdb8fve/pdb
• Descriptor: CTP synthase, MALONIC ACID, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor complex, metabolic enzyme, cytosolic protein, ligase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 122221.07

Authors

Holyoak, T.,McLeod, M.J.,Tran, N. (deposition date: 2023-01-18, release date: 2023-05-24, Last modification date: 2023-06-14)

• Primary citation: McLeod, M.J.,Tran, N.,McCluskey, G.D.,Gillis, T.D.,Bearne, S.L.,Holyoak, T.; A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.; Protein Sci., 32:e4648-e4648, 2023; PubMed: 37106216; DOI: 10.1002/pro.4648

Experimental method

X-RAY DIFFRACTION (2.4 Å)