8FVE
E coli. CTP synthase in complex with CTP (potassium malonate + 100 mM MgCl2)
Summary for 8FVE
Entry DOI | 10.2210/pdb8fve/pdb |
Descriptor | CTP synthase, MALONIC ACID, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | inhibitor complex, metabolic enzyme, cytosolic protein, ligase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 122221.07 |
Authors | Holyoak, T.,McLeod, M.J.,Tran, N. (deposition date: 2023-01-18, release date: 2023-05-24, Last modification date: 2024-05-22) |
Primary citation | McLeod, M.J.,Tran, N.,McCluskey, G.D.,Gillis, T.D.,Bearne, S.L.,Holyoak, T. A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate. Protein Sci., 32:e4648-e4648, 2023 Cited by PubMed: 37106216DOI: 10.1002/pro.4648 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)