1D2S
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CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE
Descriptor:SEX HORMONE-BINDING GLOBULIN, CALCIUM ION, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Grishkovskaya, I., Avvakumov, G.V., Sklenar, G., Dales, D., Hammond, G.L., Muller, Y.A.
Deposit date:1999-09-28
Release date:2000-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
EMBO J., 19, 2000
1F5F
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CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC
Descriptor:SEX HORMONE-BINDING GLOBULIN, CALCIUM ION, ZINC ION, ...
Authors:Avvakumov, V.A., Muller, Y.A., Hammond, G.L.
Deposit date:2000-06-14
Release date:2000-09-06
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Steroid-binding specificity of human sex hormone-binding globulin is influenced by occupancy of a zinc-binding site.
J.Biol.Chem., 275, 2000
1H30
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C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6
Descriptor:GROWTH-ARREST-SPECIFIC PROTEIN, CALCIUM ION, SULFATE ION
Authors:Sasaki, T., Knyazev, P.G., Cheburkin, Y., Gohring, W., Tisi, D., Ullrich, A., Timpl, R., Hohenester, E.
Deposit date:2002-08-21
Release date:2003-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Carboxy-Terminal Fragment of Growth-Arrest-Specific Protein Gas6: Receptor Tyrosine Kinase Activation by Laminin G-Like Domains
J.Biol.Chem., 277, 2002
1KDK
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THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA
Descriptor:Sex Hormone-Binding Globulin, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Grishkovskaya, I., Avvakumov, G.V., Hammond, G.L., Muller, Y.A.
Deposit date:2001-11-13
Release date:2002-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
J.Mol.Biol., 318, 2002
1KDM
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THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM)
Descriptor:sex hormone-binding globulin, CALCIUM ION, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Grishkovskaya, I., Avvakumov, G.V., Hammond, G.L., Muller, Y.A.
Deposit date:2001-11-13
Release date:2002-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
J.Mol.Biol., 318, 2002
1LHN
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CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL
Descriptor:SEX HORMONE-BINDING GLOBULIN, CALCIUM ION, ZINC ION, ...
Authors:Grishkovskaya, I., Avvakumov, G.V., Hammond, G.L., Catalano, M.G., Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
1LHO
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CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL
Descriptor:SEX HORMONE-BINDING GLOBULIN, CALCIUM ION, 5-ALPHA-ANDROSTANE-3-BETA,17BETA-DIOL
Authors:Grishkovskaya, I., Avvakumov, G.V., Hammond, G.L., Catalano, M.G., Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
1LHU
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CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL
Descriptor:SEX HORMONE-BINDING GLOBULIN, CALCIUM ION, ESTRADIOL
Authors:Grishkovskaya, I., Avvakumov, G.V., Hammond, G.L., Catalano, M.G., Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
1LHV
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CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH NORGESTREL
Descriptor:SEX HORMONE-BINDING GLOBULIN, CALCIUM ION, ZINC ION, ...
Authors:Grishkovskaya, I., Avvakumov, G.V., Hammond, G.L., Catalano, M.G., Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
1LHW
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CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL
Descriptor:SEX HORMONE-BINDING GLOBULIN, CALCIUM ION, 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER, ...
Authors:Avvakumov, G.V., Grishkovskaya, I., Muller, Y.A., Hammond, G.L.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.
J.Biol.Chem., 277, 2002
1PZ7
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MODULATION OF AGRIN FUNCTION BY ALTERNATIVE SPLICING AND CA2+ BINDING
Descriptor:Agrin, CALCIUM ION
Authors:Stetefeld, J., Alexandrescu, A.T., Maciejewski, M.W., Jenny, M., Rathgeb-Szabo, K., Schulthess, T., Landwehr, R., Frank, S., Ruegg, M.A., Kammerer, R.A.
Deposit date:2003-07-10
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.421 Å)
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
1PZ8
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MODULATION OF AGRIN FUNCTION BY ALTERNATIVE SPLICING AND CA2+ BINDING
Descriptor:Agrin, CALCIUM ION
Authors:Stetefeld, J., Alexandrescu, A.T., Maciejewski, M.W., Jenny, M., Rathgeb-Szabo, K., Schulthess, T., Landwehr, R., Frank, S., Ruegg, M.A., Kammerer, R.A.
Deposit date:2003-07-10
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
1PZ9
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MODULATION OF AGRIN FUNCTION BY ALTERNATIVE SPLICING AND CA2+ BINDING
Descriptor:Agrin
Authors:Stetefeld, J., Alexandrescu, A.T., Maciejewski, M.W., Jenny, M., Rathgeb-Szabo, K., Schulthess, T., Landwehr, R., Frank, S., Ruegg, M.A., Kammerer, R.A.
Deposit date:2003-07-10
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
1Q56
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NMR STRUCTURE OF THE B0 ISOFORM OF THE AGRIN G3 DOMAIN IN ITS CA2+ BOUND STATE
Descriptor:Agrin
Authors:Stetefeld, J., Alexandrescu, A.T., Maciejewski, M.W., Jenny, M., Rathgeb-Szabo, K., Schulthess, T., Landwehr, R., Frank, S., Ruegg, M.A., Kammerer, R.A.
Deposit date:2003-08-06
Release date:2004-04-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding
Structure, 12, 2004
2WJS
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CRYSTAL STRUCTURE OF THE LG1-3 REGION OF THE LAMININ ALPHA2 CHAIN
Descriptor:LAMININ SUBUNIT ALPHA-2, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Carafoli, F., Clout, N.J., Hohenester, E.
Deposit date:2009-05-28
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Lg1-3 Region of the Laminin {Alpha}2 Chain.
J.Biol.Chem., 284, 2009
3PVE
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CRYSTAL STRUCTURE OF THE G2 DOMAIN OF AGRIN FROM MUS MUSCULUS
Descriptor:Agrin, Agrin protein
Authors:Sampathkumar, P., Do, J., Bain, K., Freeman, J., Gheyi, T., Atwell, S., Thompson, D.A., Emtage, J.S., Wasserman, S., Sauder, J.M., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2010-12-07
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the G2 domain of Agrin from Mus Musculus
To be Published
5MC9
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CRYSTAL STRUCTURE OF THE HETEROTRIMERIC INTEGRIN-BINDING REGION OF LAMININ-111
Descriptor:Laminin subunit alpha-1, Laminin subunit beta-1, Laminin subunit gamma-1, ...
Authors:Pulido, D., Hohenester, E.
Deposit date:2016-11-09
Release date:2017-02-08
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal Structure of the Heterotrimeric Integrin-Binding Region of Laminin-111.
Structure, 25, 2017
1DYK
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LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR
Descriptor:LAMININ ALPHA 2 CHAIN, CALCIUM ION
Authors:Tisi, D., Talts, J.F., Timple, R., Hohenester, E.
Deposit date:2000-02-01
Release date:2001-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the C-Terminal Laminin G-Like Domain Pair of the Laminin Alpha 2 Chain Harbouring Binding Sites for Alpha-Dystroglycan and Heparin
Embo J., 19, 2000
1OKQ
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LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR, CA1 SITE MUTANT
Descriptor:LAMININ ALPHA 2 CHAIN, CALCIUM ION
Authors:Wizemann, H., Garbe, J.H.O., Friedrich, M.V.K., Timpl, R., Sasaki, T., Hohenester, E.
Deposit date:2003-07-28
Release date:2003-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Distinct Requirements for Heparin and Alpha-Dystroglycan Binding Revealed by Structure-Based Mutagenesis of the Laminin Alpha2 Lg4-Lg5 Domain Pair
J.Mol.Biol., 332, 2003
2C5D
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STRUCTURE OF A MINIMAL GAS6-AXL COMPLEX
Descriptor:GROWTH-ARREST-SPECIFIC PROTEIN 6 PRECURSOR, TYROSINE-PROTEIN KINASE RECEPTOR UFO, CALCIUM ION, ...
Authors:Sasaki, T., Knyazev, P.G., Clout, N.J., Cheburkin, Y., Goehring, W., Ullrich, A., Timpl, R., Hohenester, E.
Deposit date:2005-10-26
Release date:2005-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Basis for Gas6-Axl Signalling.
Embo J., 25, 2006
2JD4
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MOUSE LAMININ ALPHA1 CHAIN, DOMAINS LG4-5
Descriptor:LAMININ SUBUNIT ALPHA-1, MAGNESIUM ION, CHLORIDE ION
Authors:Harrison, D., Hussain, S.A., Combs, A.C., Ervasti, J.M., Yurchenco, P.D., Hohenester, E.
Deposit date:2007-01-04
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure and Cell Surface Anchorage Sites of Laminin {Alpha}1Lg4-5.
J.Biol.Chem., 282, 2007
3V64
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CRYSTAL STRUCTURE OF AGRIN AND LRP4
Descriptor:Low-density lipoprotein receptor-related protein 4, agrin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zong, Y., Zhang, B., Gu, S., Lee, K., Zhou, J., Yao, G., Figueiedo, D., Perry, K., Mei, L., Jin, R.
Deposit date:2011-12-18
Release date:2012-04-25
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of agrin-LRP4-MuSK signaling.
Genes Dev., 26, 2012
3V65
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CRYSTAL STRUCTURE OF AGRIN AND LRP4 COMPLEX
Descriptor:Agrin, Low-density lipoprotein receptor-related protein 4, CALCIUM ION
Authors:Zong, Y., Jin, R.
Deposit date:2011-12-18
Release date:2012-04-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of agrin-LRP4-MuSK signaling.
Genes Dev., 26, 2012
4RA0
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AN ENGINEERED AXL 'DECOY RECEPTOR' EFFECTIVELY SILENCES THE GAS6-AXL SIGNALING AXIS
Descriptor:Growth arrest-specific protein 6, Tyrosine-protein kinase receptor UFO, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kariolis, M.S., Kapur, S., Mathews, I.I., Cochran, J.R.
Deposit date:2014-09-09
Release date:2014-09-24
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Nat.Chem.Biol., 10, 2014
5IK4
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LAMININ A2LG45 C-FORM, APO.
Descriptor:Laminin subunit alpha-2, CALCIUM ION, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, ...
Authors:Briggs, D.C., Hohenester, E., Campbell, K.P.
Deposit date:2016-03-03
Release date:2016-08-10
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Nat.Chem.Biol., 12, 2016
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