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4JNK
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Lactate Dehydrogenase A in complex with inhibitor compound 22
Descriptor: (2R)-2-{[5-cyano-4-(3,4-dichlorophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)propanamide, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2013-03-15
Release date:2013-05-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Bioorg.Med.Chem.Lett., 23, 2013
4H7P
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Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin
Descriptor: Malate dehydrogenase, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-09-20
Release date:2012-10-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin
To be Published
4KDE
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Crystal Structure of the Apo Form of Thermus thermophilus Malate Dehydrogenase
Descriptor: Malate dehydrogenase
Authors:Hsu, C.-H, Hong, C.-H, Chang, Y.-Y.
Deposit date:2013-04-25
Release date:2014-02-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Crystal structures and molecular dynamics simulations of thermophilic malate dehydrogenase reveal critical loop motion for co-substrate binding.
Plos One, 8, 2013
4I9N
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Crystal structure of rabbit LDHA in complex with AP28161 and AP28122
Descriptor: 6-({2-[(5-chloro-4-{[(2S)-2,3-dihydroxypropyl]oxy}-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, 6-[3-(carboxymethoxy)-5-fluorophenyl]pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain
Authors:Zhou, T, Kohlmann, A, Stephan, Z.G, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C.
Deposit date:2012-12-05
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
J.Med.Chem., 56, 2013
4I9U
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Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256
Descriptor: 6-({2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain
Authors:Zhou, T, Kohlmann, A, Stephan, Z.G, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C.
Deposit date:2012-12-05
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
J.Med.Chem., 56, 2013
4KDF
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Crystal Structure of Thermus thermophilus Malate Dehydrogenase in Complex with NAD
Descriptor: Malate dehydrogenase, SULFATE ION
Authors:Hsu, C.-H, Hong, C.-H, Chang, Y.-Y.
Deposit date:2013-04-25
Release date:2014-02-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.356 Å)
Cite:Crystal structures and molecular dynamics simulations of thermophilic malate dehydrogenase reveal critical loop motion for co-substrate binding.
Plos One, 8, 2013
4L4R
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Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme
Descriptor: L-lactate dehydrogenase A chain
Authors:Dempster, S, Harper, S, Moses, J.E, Dreveny, I.
Deposit date:2013-06-09
Release date:2014-04-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.
Acta Crystallogr.,Sect.D, 70, 2014
4L4S
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Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase A chain
Authors:Dempster, S, Harper, S, Moses, J.E, Dreveny, I.
Deposit date:2013-06-09
Release date:2014-04-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.
Acta Crystallogr.,Sect.D, 70, 2014
4LN1
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CRYSTAL STRUCTURE OF L-lactate dehydrogenase from Bacillus cereus ATCC 14579 complexed with calcium, NYSGRC Target 029452
Descriptor: CALCIUM ION, L-lactate dehydrogenase 1
Authors:Malashkevich, V.N, Bonanno, J.B, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Khafizov, K, Seidel, R, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2013-07-11
Release date:2013-07-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of L-lactate dehydrogenase from Bacillus cereus ATCC 14579 complexed with calcium, NYSGRC Target 029452
To be Published
4LMR
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BU of 4lmr by Molmil
Crystal structure of L-lactate dehydrogenase from Bacillus cereus ATCC 14579, NYSGRC Target 029452
Descriptor: L-lactate dehydrogenase 1
Authors:Malashkevich, V.N, Bonanno, J.B, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Khafizov, K, Seidel, R, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2013-07-10
Release date:2013-07-31
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of L-lactate dehydrogenase from Bacillus cereus ATCC 14579, NYSGRC Target 029452
To be Published
1HYH
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BU of 1hyh by Molmil
CRYSTAL STRUCTURE OF L-2-HYDROXYISOCAPROATE DEHYDROGENASE FROM LACTOBACILLUS CONFUSUS AT 2.2 ANGSTROMS RESOLUTION-AN EXAMPLE OF STRONG ASYMMETRY BETWEEN SUBUNITS
Descriptor: L-2-HYDROXYISOCAPROATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Niefind, K, Hecht, H.-J, Schomburg, D.
Deposit date:1995-06-05
Release date:1995-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of L-2-hydroxyisocaproate dehydrogenase from Lactobacillus confusus at 2.2 A resolution. An example of strong asymmetry between subunits.
J.Mol.Biol., 251, 1995
1HLP
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BU of 1hlp by Molmil
STRUCTURAL FEATURES STABILIZING HALOPHILIC MALATE DEHYDROGENASE FROM AN ARCHAEBACTERIUM
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dym, O, Mevarech, M, Sussman, J.L.
Deposit date:1994-10-04
Release date:1995-01-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Features That Stabilize Halophilic Malate Dehydrogenase from an Archaebacterium.
Science, 267, 1995
1HYE
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BU of 1hye by Molmil
CRYSTAL STRUCTURE OF THE MJ0490 GENE PRODUCT, THE FAMILY OF LACTATE/MALATE DEHYDROGENASE, DIMERIC STRUCTURE
Descriptor: L-LACTATE/MALATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Lee, B.I, Chang, C, Cho, S.-J, Suh, S.W.
Deposit date:2001-01-19
Release date:2001-04-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the MJ0490 gene product of the hyperthermophilic archaebacterium Methanococcus jannaschii, a novel member of the lactate/malate family of dehydrogenases.
J.Mol.Biol., 307, 2001
1HYG
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BU of 1hyg by Molmil
Crystal structure of MJ0490 gene product, the family of lactate/malate dehydrogenase
Descriptor: L-LACTATE/MALATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Lee, B.I, Chang, C, Cho, S.-J, Suh, S.W.
Deposit date:2001-01-19
Release date:2001-04-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the MJ0490 gene product of the hyperthermophilic archaebacterium Methanococcus jannaschii, a novel member of the lactate/malate family of dehydrogenases
J.Mol.Biol., 307, 2001
1IB6
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CRYSTAL STRUCTURE OF R153C E. COLI MALATE DEHYDROGENASE
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Bell, J.K, Yennawar, H.P, Wright, S.K, Thompson, J.R, Viola, R.E, Banaszak, L.J.
Deposit date:2001-03-27
Release date:2001-09-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analyses of a Malate Dehydrogenase with a Variable Active Site
J.Biol.Chem., 276, 2001
1I0Z
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HUMAN HEART L-LACTATE DEHYDROGENASE H CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-LACTATE DEHYDROGENASE H CHAIN, OXAMIC ACID
Authors:Read, J.A, Winter, V.J, Eszes, C.M, Sessions, R.B, Brady, R.L.
Deposit date:2001-01-30
Release date:2001-03-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.
Proteins, 43, 2001
1IZ9
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BU of 1iz9 by Molmil
Crystal Structure of Malate Dehydrogenase from Thermus thermophilus HB8
Descriptor: MALATE DEHYDROGENASE
Authors:Hirose, R, Hasegawa, T, Yamano, A, Kuramitsu, S, Hamada, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-10-01
Release date:2002-10-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Malate Dehydrogenase from Thermus themrophilus HB8
To be published
1IE3
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BU of 1ie3 by Molmil
CRYSTAL STRUCTURE OF R153C E. COLI MALATE DEHYDROGENASE
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID
Authors:Bell, J.K, Yennawar, H.P, Wright, S.K, Thompson, J.R, Viola, R.E, Banaszak, L.J.
Deposit date:2001-04-05
Release date:2001-09-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analyses of a Malate Dehydrogenase with a Variable Active Site
J.Biol.Chem., 276, 2001
1I10
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HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ACETATE ION, L-LACTATE DEHYDROGENASE M CHAIN, ...
Authors:Read, J.A, Winter, V.J, Eszes, C.M, Sessions, R.B, Brady, R.L.
Deposit date:2001-01-30
Release date:2001-03-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.
Proteins, 43, 2001
1LLD
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BU of 1lld by Molmil
MOLECULAR BASIS OF ALLOSTERIC ACTIVATION OF BACTERIAL L-LACTATE DEHYDROGENASE
Descriptor: L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Iwata, S, Ohta, T.
Deposit date:1992-06-08
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of allosteric activation of bacterial L-lactate dehydrogenase.
J.Mol.Biol., 230, 1993
1LDN
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STRUCTURE OF A TERNARY COMPLEX OF AN ALLOSTERIC LACTATE DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS AT 2.5 ANGSTROMS RESOLUTION
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Wigley, D.B, Gamblin, S.J, Turkenburg, J.P, Dodson, E.J, Piontek, K, Muirhead, H, Holbrook, J.J.
Deposit date:1991-11-19
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution.
J.Mol.Biol., 223, 1992
1LDM
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BU of 1ldm by Molmil
Refined crystal structure of dogfish M4 apo-lactate dehydrogenase
Descriptor: M4 LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID
Authors:Griffith, J.P, Rossmann, M.G.
Deposit date:1987-11-25
Release date:1989-07-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.
J.Mol.Biol., 198, 1987
1LLC
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STRUCTURE DETERMINATION OF THE ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS CASEI AT 3.0 ANGSTROMS RESOLUTION
Descriptor: 1,6-di-O-phosphono-alpha-D-fructofuranose, L-LACTATE DEHYDROGENASE, SULFATE ION
Authors:Buehner, M, Hecht, H.J, Hensel, R.
Deposit date:1988-11-21
Release date:1989-07-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:STRUCTURE DETERMINATION OF THE ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS-CASEI AT 3A RESOLUTION.
Acta Crystallogr.,Sect.A, 40, 1984
1LTH
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T AND R STATES IN THE CRYSTALS OF BACTERIAL L-LACTATE DEHYDROGENASE REVEAL THE MECHANISM FOR ALLOSTERIC CONTROL
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, L-LACTATE DEHYDROGENASE (T- AND R- STATE TETRAMER COMPLEX), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Iwata, S, Ohta, T.
Deposit date:1995-01-04
Release date:1995-03-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:T and R states in the crystals of bacterial L-lactate dehydrogenase reveal the mechanism for allosteric control.
Nat.Struct.Biol., 1, 1994
1LDB
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STRUCTURE DETERMINATION AND REFINEMENT OF BACILLUS STEAROTHERMOPHILUS LACTATE DEHYDROGENASE
Descriptor: APO-L-LACTATE DEHYDROGENASE, SULFATE ION
Authors:Piontek, K, Rossmann, M.G.
Deposit date:1989-03-27
Release date:1989-07-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure determination and refinement of Bacillus stearothermophilus lactate dehydrogenase.
Proteins, 7, 1990

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