Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5OGR
DownloadVisualize
BU of 5ogr by Molmil
Structure of cathepsin B1 from Schistosoma mansoni in complex with WRR286 inhibitor
Descriptor: 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE, ACETATE ION, Cathepsin B-like peptidase (C01 family)
Authors:Jilkova, A, Rezacova, P, Brynda, J, Mares, M.
Deposit date:2017-07-13
Release date:2018-11-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
Acs Infect Dis., 2020
5OGQ
DownloadVisualize
BU of 5ogq by Molmil
Structure of cathepsin B1 from Schistosoma mansoni in complex with WRR391 inhibitor
Descriptor: ACETATE ION, Cathepsin B-like peptidase (C01 family), ethyl 1-[[(2~{S})-3-(4-hydroxyphenyl)-1-oxidanylidene-1-[[(3~{S})-1-phenyl-5-pyridin-2-ylsulfonyl-pentan-3-yl]amino]propan-2-yl]carbamoyl]piperidine-4-carboxylate
Authors:Jilkova, A, Rezacova, P, Brynda, J, Mares, M.
Deposit date:2017-07-13
Release date:2018-11-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
Acs Infect Dis., 2020
5MQY
DownloadVisualize
BU of 5mqy by Molmil
CATHEPSIN L IN COMPLEX WITH 4-[1,3-benzodioxol-5-ylmethyl(2-phenoxyethyl)amino]-5-fluoropyrimidine-2-carbonitrile
Descriptor: 1,2-ETHANEDIOL, 4-[1,3-benzodioxol-5-ylmethyl(2-phenoxyethyl)amino]-5-fluoropyrimidine-2-carbonitrile, Cathepsin L1
Authors:Kuglstatter, A, Stihle, M, Benz, J.
Deposit date:2016-12-21
Release date:2017-03-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.
J. Med. Chem., 60, 2017
5MBM
DownloadVisualize
BU of 5mbm by Molmil
Cathepsin B in complex with DARPin 8h6
Descriptor: Cathepsin B, DARPin 8h6
Authors:Turk, D, Kramer, L, Renko, M, Turk, B.
Deposit date:2016-11-08
Release date:2017-12-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Cathepsin B in complex with DARPin 8h6
To Be Published
5MBL
DownloadVisualize
BU of 5mbl by Molmil
Cathepsin B in complex with DARPin 81
Descriptor: Cathepsin B, DARPin 81, SULFATE ION
Authors:Turk, D, Kramer, L, Renko, M, Turk, B.
Deposit date:2016-11-08
Release date:2017-12-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Cathepsin B in complex with DARPin 81
To Be Published
5MAJ
DownloadVisualize
BU of 5maj by Molmil
CATHEPSIN L IN COMPLEX WITH 4-[cyclopentyl(imidazo[1,2-a]pyridin-2-ylmethyl)amino]-6-morpholino-1,3,5-triazine-2-carbonitrile
Descriptor: 1,2-ETHANEDIOL, Cathepsin L1, ~{N}-cyclopentyl-~{N}-(imidazo[1,2-a]pyridin-2-ylmethyl)-4-(iminomethyl)-6-morpholin-4-yl-1,3,5-triazin-2-amine
Authors:Kuglstatter, A, Stihle, M, Benz, J.
Deposit date:2016-11-03
Release date:2017-01-11
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1 Å)
Cite:Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.
ChemMedChem, 12, 2017
5MAE
DownloadVisualize
BU of 5mae by Molmil
CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide
Descriptor: 1,2-ETHANEDIOL, Cathepsin L1, [4-[cyclopentyl(pyrazin-2-ylmethyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]methylideneazanide
Authors:Kuglstatter, A, Stihle, M, Benz, J.
Deposit date:2016-11-03
Release date:2017-01-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1 Å)
Cite:Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.
ChemMedChem, 12, 2017
5JT8
DownloadVisualize
BU of 5jt8 by Molmil
Structural basis for the limited antibody cross reactivity between the mite allergens Blo t 1 and Der p 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Blo t 1 allergen, ...
Authors:Meno, K, Kastrup, J.S, Gajhede, M.
Deposit date:2016-05-09
Release date:2017-05-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1.
Allergy, 72, 2017
5JH3
DownloadVisualize
BU of 5jh3 by Molmil
Human cathepsin K mutant C25S
Descriptor: ACETATE ION, CHLORIDE ION, Cathepsin K, ...
Authors:Novinec, M, Korenc, M, Lenarcic, B.
Deposit date:2016-04-20
Release date:2016-11-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An allosteric site enables fine-tuning of cathepsin K by diverse effectors.
FEBS Lett., 590, 2016
5JA7
DownloadVisualize
BU of 5ja7 by Molmil
Human cathepsin K mutant C25S in complex with the allosteric effector NSC94914
Descriptor: ACETATE ION, Cathepsin K, GLYCEROL, ...
Authors:Novinec, M, Korenc, M, Lenarcic, B.
Deposit date:2016-04-12
Release date:2016-11-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:An allosteric site enables fine-tuning of cathepsin K by diverse effectors.
FEBS Lett., 590, 2016
5J94
DownloadVisualize
BU of 5j94 by Molmil
Human cathepsin K mutant C25S in complex with the allosteric effector NSC13345
Descriptor: 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, Cathepsin K, SULFATE ION
Authors:Novinec, M, Korenc, M, Lenarcic, B, Baici, A.
Deposit date:2016-04-08
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.22002459 Å)
Cite:A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.
Nat Commun, 5, 2014
5I4H
DownloadVisualize
BU of 5i4h by Molmil
Caught in the Act: The Crystal Structure of cleaved Cathepsin L bound to the active site of Cathepsin L
Descriptor: Cathepsin L1, GLYCEROL, SULFATE ION
Authors:Sosnowski, P, Turk, D.
Deposit date:2016-02-12
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Febs Lett., 590, 2016
5FPW
DownloadVisualize
BU of 5fpw by Molmil
proCathepsin B S9 from Trypanosoma congolense
Descriptor: PRO CATHEPSIN B S9
Authors:Sevajol, M, Biteau, N, Baltz, T, Franzetti, B, Vellieux, F.M.D.
Deposit date:2015-12-03
Release date:2016-02-17
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:2.1 Angstrom Crystal Structure of Pro Cathepsin B S9 from Trypanosoma Congolense
Ph D Thesis
5F02
DownloadVisualize
BU of 5f02 by Molmil
CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide
Descriptor: (2~{S},4~{R})-4-[(2-chloranyl-4-methoxy-phenyl)-bis(oxidanyl)-$l^{4}-sulfanyl]-1-[3-(5-chloranylpyridin-2-yl)azetidin-3-yl]carbonyl-~{N}-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide, Cathepsin L1, GLYCEROL
Authors:Banner, D, Benz, J, Stihle, M, Kuglstatter, A.
Deposit date:2015-11-27
Release date:2016-02-24
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:A Real-World Perspective on Molecular Design.
J.Med.Chem., 59, 2016
5EGW
DownloadVisualize
BU of 5egw by Molmil
2.70 A crystal structure of the Amb a 11 cysteine protease, a major ragweed pollen allergen, in its proform
Descriptor: Cysteine protease
Authors:Briozzo, P, Kopecny, D.
Deposit date:2015-10-27
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen.
J.Biol.Chem., 291, 2016
5EF4
DownloadVisualize
BU of 5ef4 by Molmil
2.05 A crystal structure of the Amb a 11 cysteine protease, a major ragweed pollen allergen, in its proform
Descriptor: Cysteine protease, GLYCEROL
Authors:Briozzo, P, Kopecny, D, Savko, M.
Deposit date:2015-10-23
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen.
J.Biol.Chem., 291, 2016
5A24
DownloadVisualize
BU of 5a24 by Molmil
Crystal structure of Dionain-1, the major endopeptidase in the Venus flytrap digestive juice
Descriptor: DIONAIN-1, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, PHOSPHATE ION
Authors:Risor, M.W, Thomsen, L.R, Sanggaard, K.W, Nielsen, T.A, Thogersen, I.B, Lukassen, M.V, Rossen, L, Garcia-Ferrer, I, Guevara, T, Meinjohanns, E, Nielsen, N.C, Gomis-Ruth, F.X, Enghild, J.J.
Deposit date:2015-05-12
Release date:2015-12-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.
J.Biol.Chem., 291, 2016
4YYW
DownloadVisualize
BU of 4yyw by Molmil
Ficin D2
Descriptor: Ficin isoform D, SULFATE ION
Authors:Azarkan, M, Baeyens-Volant, D, Loris, R.
Deposit date:2015-03-24
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.446 Å)
Cite:Crystal structure of four variants of the protease Ficin from the common fig
To Be Published
4YYV
DownloadVisualize
BU of 4yyv by Molmil
Ficin isoform C crystal form II
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE, Ficin isoform C, SULFATE ION
Authors:Azarkan, M, Baeyens-Volant, D, Loris, R.
Deposit date:2015-03-24
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Crystal structure of four variants of the protease Ficin from the common fig
To Be Published
4YYU
DownloadVisualize
BU of 4yyu by Molmil
Ficin C crystal form I
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ficin isoform C, SULFATE ION
Authors:Azarkan, M, Baeyens-Volant, D, Loris, R.
Deposit date:2015-03-24
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.177 Å)
Cite:Crystal structure of four variants of the protease Ficin from the common fig
To Be Published
4YYS
DownloadVisualize
BU of 4yys by Molmil
Ficin B crystal form II
Descriptor: Ficin isoform B, PHOSPHATE ION
Authors:Azarkan, M, Baeyens-Volant, D, Loris, R.
Deposit date:2015-03-24
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structure of four variants of the protease Ficin from the common fig
To Be Published
4YYR
DownloadVisualize
BU of 4yyr by Molmil
Ficin B crystal form I
Descriptor: Ficin B, SULFATE ION
Authors:Azarkan, M, Baeyens-Volant, D, Loris, R.
Deposit date:2015-03-24
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.349 Å)
Cite:Crystal structure of four variants of the protease Ficin from the common fig
To Be Published
4YYQ
DownloadVisualize
BU of 4yyq by Molmil
Ficin A
Descriptor: Ficin isoform A
Authors:Azarkan, M, Baeyens-Volant, D, Loris, R.
Deposit date:2015-03-24
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.594 Å)
Cite:Crystal structure of four variants of the protease Ficin from the common fig
To Be Published
4YVA
DownloadVisualize
BU of 4yva by Molmil
Cathepsin K co-crystallized with actinomycetes extract
Descriptor: Cathepsin K, SULFATE ION
Authors:Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
Deposit date:2015-03-19
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.
J.Nat.Prod., 79, 2016
4YV8
DownloadVisualize
BU of 4yv8 by Molmil
Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal
Descriptor: Cathepsin K, Lichostatinal, SULFATE ION
Authors:Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
Deposit date:2015-03-19
Release date:2016-05-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.
J.Nat.Prod., 79, 2016

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon