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6FNE
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BU of 6fne by Molmil
Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain
Descriptor: (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one, IQ motif and SEC7 domain-containing protein 1, NONAETHYLENE GLYCOL
Authors:Nawrotek, A, Zeghouf, M, Cherfils, J.
Deposit date:2018-02-03
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.
Nat.Chem.Biol., 15, 2019
9EVM
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BU of 9evm by Molmil
High pH (8.0) nitrite-bound MSOX movie series dataset 30 of the copper nitrite reductase (NirK) from Bradyrhizobium japonicum USDA110 [20.7 MGy]
Descriptor: COPPER (II) ION, Copper-containing nitrite reductase, NITRITE ION, ...
Authors:Rose, S.L, Ferroni, F.M, Horrell, S, Brondino, C.D, Eady, R.R, Jaho, S, Hough, M.A, Owen, A.L, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2024-03-30
Release date:2024-07-24
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Spectroscopically Validated pH-dependent MSOX Movies Provide Detailed Mechanism of Copper Nitrite Reductases.
J.Mol.Biol., 436, 2024
7KNE
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BU of 7kne by Molmil
Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-04
Release date:2020-12-16
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7KNI
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BU of 7kni by Molmil
Cryo-EM structure of Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-04
Release date:2020-12-16
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7KNB
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BU of 7knb by Molmil
Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-04
Release date:2020-12-09
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
4D5M
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BU of 4d5m by Molmil
Gonadotropin-releasing hormone agonist
Descriptor: PHOSPHATE ION, TRIPTORELIN
Authors:Legrand, P, Le Du, M.-H, Valery, C, Deville-Foillard, S, Paternostre, M, Artzner, F.
Deposit date:2014-11-05
Release date:2015-08-12
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Atomic View of the Histidine Environment Stabilizing Higher- Ph Conformations of Ph-Dependent Proteins.
Nat.Commun., 6, 2015
8GA0
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BU of 8ga0 by Molmil
CLC-ec1 E202Y at pH 4.5 100mM Cl Turn
Descriptor: H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GAH
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BU of 8gah by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA3
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BU of 8ga3 by Molmil
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA1
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BU of 8ga1 by Molmil
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA5
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BU of 8ga5 by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
5DD8
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BU of 5dd8 by Molmil
The Crystal structure of HucR mutant (HucR-E48Q) from Deinococcus radiodurans
Descriptor: CHLORIDE ION, Transcriptional regulator, MarR family
Authors:Deochand, D.K, Perera, I.C, Crochet, R.B, Gilbert, N.C, Newcomer, M.E, Grove, A.
Deposit date:2015-08-24
Release date:2015-09-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices.
Mol Biosyst, 12, 2016
6JH7
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BU of 6jh7 by Molmil
Crystal structure of AerF from Microcystis aeruginosa
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, Short chain dehydrogenase family protein, ...
Authors:Qiu, X.
Deposit date:2019-02-17
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin
J.Struct.Biol., 2019
6JHB
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BU of 6jhb by Molmil
Crystal structure of NADPH and 4-hydroxyphenylpyruvic acid bound AerF from Microcystis aeruginosa
Descriptor: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase family protein
Authors:Qiu, X, Wei, Y, Zhu, W.
Deposit date:2019-02-17
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin
J.Struct.Biol., 2019
6JHA
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BU of 6jha by Molmil
Crystal structure of NADPH bound AerF from Microcystis aeruginosa
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase family protein, TRIETHYLENE GLYCOL
Authors:Qiu, X.
Deposit date:2019-02-17
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin
J.Struct.Biol., 2019
3CQN
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BU of 3cqn by Molmil
Crystal Structure of the Lipocalin domain of Violaxanthin de-epoxidase (VDE) at pH7
Descriptor: Violaxanthin de-epoxidase, chloroplast
Authors:Arnoux, P, Morosinotto, T, Pignol, D.
Deposit date:2008-04-03
Release date:2009-04-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural basis for the pH-dependent xanthophyll cycle in Arabidopsis thaliana.
Plant Cell, 21, 2009
3CQR
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BU of 3cqr by Molmil
Crystal Structure of the Lipocalin domain of Violaxanthin de-epoxidase (VDE) at pH5
Descriptor: GADOLINIUM ATOM, Violaxanthin de-epoxidase, chloroplast
Authors:Arnoux, P, Morosinotto, T, Pignol, D.
Deposit date:2008-04-03
Release date:2009-04-21
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural basis for the pH-dependent xanthophyll cycle in Arabidopsis thaliana.
Plant Cell, 21, 2009
3VZJ
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BU of 3vzj by Molmil
Crystal structure of the Bacillus circulans endo-beta-(1,4)-xylanase (BcX) E172H mutant
Descriptor: Endo-1,4-beta-xylanase, SULFATE ION
Authors:Ludwiczek, M.L, D'Angelo, I, Yalloway, G.N, Okon, M, Nielsen, J.E, Strynadka, N.C, Withers, S.G, McIntosh, L.P.
Deposit date:2012-10-14
Release date:2013-05-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase
Biochemistry, 52, 2013
2ZCU
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BU of 2zcu by Molmil
Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli
Descriptor: COPPER (II) ION, Uncharacterized oxidoreductase ytfG
Authors:Kim, I.K, Yim, H.S, Kim, M.K, Kim, D.W, Kim, Y.M, Cha, S.S, Kang, S.O.
Deposit date:2007-11-13
Release date:2008-05-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli
J.Mol.Biol., 379, 2008
6NSJ
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BU of 6nsj by Molmil
CryoEM structure of Helicobacter pylori urea channel in closed state
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel
Authors:Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H.
Deposit date:2019-01-24
Release date:2019-04-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM.
Sci Adv, 5, 2019
2ZBJ
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BU of 2zbj by Molmil
Crystal structure of Dioclea rostrata lectin
Descriptor: CALCIUM ION, Lectin alpha chain, MANGANESE (II) ION, ...
Authors:de Oliveira, T.M, Delatorre, P, da Rocha, B.A.M, de Sousa, E.P, Nascimento, K.S, Bezerra, G.A, Moura, T.R, Benevides, R.G, Bezerra, E.H.S, Moreno, F.B.M.B, Freire, V.N, de Azevedo Jr, W.F, Cavada, B.S.
Deposit date:2007-10-22
Release date:2008-08-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of Dioclea rostrata lectin: Insights into understanding the pH-dependent dimer-tetramer equilibrium and the structural basis for carbohydrate recognition in Diocleinae lectins
J.Struct.Biol., 164, 2008
6NSK
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BU of 6nsk by Molmil
CryoEM structure of Helicobacter pylori urea channel in open state.
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel
Authors:Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H.
Deposit date:2019-01-24
Release date:2019-04-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM.
Sci Adv, 5, 2019
3A0N
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BU of 3a0n by Molmil
Crystal structure of D-glucuronic acid-bound alginate lyase vAL-1 from Chlorella virus
Descriptor: VAL-1, beta-D-glucopyranuronic acid
Authors:Ogura, K, Yamasaki, M, Hashidume, T, Yamada, T, Mikami, B, Hashimoto, W, Murata, K.
Deposit date:2009-03-23
Release date:2009-10-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of family 14 polysaccharide lyase with pH-dependent modes of action
J.Biol.Chem., 284, 2009
2RL9
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BU of 2rl9 by Molmil
Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to trimannoside
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, Cation-dependent mannose-6-phosphate receptor, ...
Authors:Olson, L.J, Hindsgaul, O, Dahms, N.M, Kim, J.-J.P.
Deposit date:2007-10-18
Release date:2008-02-12
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor.
J.Biol.Chem., 283, 2008
5NIJ
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BU of 5nij by Molmil
Crystal structure of arabidopsis thaliana legumain isoform gamma in two-chain activation state
Descriptor: CITRIC ACID, SULFATE ION, Vacuolar-processing enzyme gamma-isozyme
Authors:Zauner, F.B, Dall, E, Brandstetter, H.
Deposit date:2017-03-24
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation.
Plant Cell, 30, 2018

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