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2O98
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BU of 2o98 by Molmil
Structure of the 14-3-3 / H+-ATPase plant complex
Descriptor: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ...
Authors:Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C.
Deposit date:2006-12-13
Release date:2007-04-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy
Mol.Cell, 25, 2007
2NPM
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BU of 2npm by Molmil
crystal structure of Cryptosporidium parvum 14-3-3 protein in complex with peptide
Descriptor: 14-3-3 domain containing protein, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Dong, A, Lew, J, Wasney, G, Ren, H, Lin, L, Hassanali, A, Qiu, W, Zhao, Y, Doyle, D, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC)
Deposit date:2006-10-27
Release date:2006-11-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Characterization of 14-3-3 proteins from Cryptosporidium parvum.
Plos One, 6, 2011
7PWZ
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BU of 7pwz by Molmil
Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228
Descriptor: 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ...
Authors:Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C.
Deposit date:2021-10-07
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
7PWT
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BU of 7pwt by Molmil
Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptor alpha phosphopeptide, stabilised by pyrrolidone derivative 228
Descriptor: (2~{R})-1-(2-hydroxyphenyl)-2-(4-nitrophenyl)-4-oxidanyl-3-(phenylcarbonyl)-2~{H}-pyrrol-5-one, 14-3-3 protein sigma, C-terminus of Estrogen receptor alpha, ...
Authors:Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C.
Deposit date:2021-10-07
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
7QIK
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BU of 7qik by Molmil
SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma
Descriptor: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ...
Authors:Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A.
Deposit date:2021-12-15
Release date:2021-12-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma
To Be Published
7QIP
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BU of 7qip by Molmil
SARS-CoV-2 Nucleocapsid phosphopeptide 201-210 bound to human 14-3-3 sigma
Descriptor: 14-3-3 protein sigma, ARG-GLY-TPO-SER-PRO-ALA-ARG-MET, CHLORIDE ION
Authors:Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A.
Deposit date:2021-12-15
Release date:2021-12-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma
To Be Published
1O9C
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BU of 1o9c by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9F
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BU of 1o9f by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
7QI1
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BU of 7qi1 by Molmil
Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424
Descriptor: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ...
Authors:Stevers, L.M, Ottmann, C.
Deposit date:2021-12-14
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.
Nat Commun, 13, 2022
1O9D
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BU of 1o9d by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9E
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BU of 1o9e by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1QJB
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BU of 1qjb by Molmil
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
Authors:Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
7AEW
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BU of 7aew by Molmil
14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and non-canonical binding motifs
Descriptor: 14-3-3 protein sigma, Aminopeptidase N, CHLORIDE ION, ...
Authors:Kiehstaller, S, Hennig, S.
Deposit date:2020-09-18
Release date:2020-11-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif.
J.Biol.Chem., 295, 2020
7AYF
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BU of 7ayf by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110
Descriptor: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-12
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AXN
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BU of 7axn by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026
Descriptor: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-10
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ2
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BU of 7az2 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014
Descriptor: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-14
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.081 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AOG
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BU of 7aog by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C.
Deposit date:2020-10-14
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ1
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BU of 7az1 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013
Descriptor: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Ottmann, C.
Deposit date:2020-11-14
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
4JC3
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BU of 4jc3 by Molmil
14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION
Authors:Bier, D, Ottmann, C.
Deposit date:2013-02-21
Release date:2013-05-15
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4JDD
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BU of 4jdd by Molmil
14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN
Authors:Bier, D, Ottmann, C.
Deposit date:2013-02-25
Release date:2013-05-15
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4HKC
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BU of 4hkc by Molmil
14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
Descriptor: 14-3-3 protein zeta/delta, GLYCEROL, alpha-4 integrin derived phosphorylated peptide
Authors:Bonet, R, Campbell, I.D.
Deposit date:2012-10-15
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of 14-3-3-zeta Interactions with integrin tails
J.Mol.Biol., 425, 2013
4IHL
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BU of 4ihl by Molmil
Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
Descriptor: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ...
Authors:Molzan, M, Ottmann, C.
Deposit date:2012-12-19
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
4IEA
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BU of 4iea by Molmil
14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide
Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase
Authors:Molzan, M, Ottmann, C.
Deposit date:2012-12-13
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
8BTQ
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BU of 8btq by Molmil
Small molecule stabilizer for 14-3-3/ChREBP (Cmd1-soaking)
Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ...
Authors:Pennings, M.A.M, Visser, E.J, Ottmann, C.
Deposit date:2022-11-29
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Biorxiv, 2024
8BWH
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BU of 8bwh by Molmil
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42)
Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ...
Authors:Pennings, M.A.M, Visser, E.J, Ottmann, C.
Deposit date:2022-12-06
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Biorxiv, 2024

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