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9F48
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BU of 9f48 by Molmil
KS + AT di-domain of polyketide synthase 13 in Mycobacterium tuberculosis
Descriptor: Polyketide synthase Pks13
Authors:Johnston, H.E, Futterer, K.
Deposit date:2024-04-26
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:CryoEM structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis
To be published
4V8L
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Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase
Descriptor: FATTY ACID SYNTHASE, FLAVIN MONONUCLEOTIDE
Authors:Boehringer, D, Ban, N, Leibundgut, M.
Deposit date:2012-12-06
Release date:2014-07-09
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:7.5-A Cryo-Em Structure of the Mycobacterial Fatty Acid Synthase.
J.Mol.Biol., 425, 2013
1EK4
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BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH DODECANOIC ACID TO 1.85 RESOLUTION
Descriptor: BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I, LAURIC ACID
Authors:Olsen, J.G, Kadziola, A, Siggaard-Andersen, M, von Wettstein-Knowles, P, Larsen, S.
Deposit date:2000-03-06
Release date:2001-04-11
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.
Structure, 9, 2001
6Y2J
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BU of 6y2j by Molmil
Crystal structure of M. tuberculosis KasA in complex with 4,4,4-trifluoro-N-(isoquinolin-6-yl)butane-1-sulfonamide
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, 4,4,4-tris(fluoranyl)-~{N}-isoquinolin-6-yl-butane-1-sulfonamide, SODIUM ION, ...
Authors:Chung, C.
Deposit date:2020-02-16
Release date:2020-04-08
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.886 Å)
Cite:Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Acs Infect Dis., 6, 2020
7ZSK
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K3DAK4 bimodule core of BGC11 from Brevibacillus brevis.
Descriptor: Putative polyketide synthase
Authors:Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T.
Deposit date:2022-05-07
Release date:2022-09-21
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:The structure of a polyketide synthase bimodule core.
Sci Adv, 8, 2022
7F27
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Crystal structure of polyketide ketosynthase
Descriptor: 3-oxoacyl-(Acyl-carrier-protein) synthase
Authors:Kim, Y, Lee, W.C.
Deposit date:2021-06-10
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.806 Å)
Cite:Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis.
Sci Rep, 11, 2021
1KAS
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BU of 1kas by Molmil
BETA-KETOACYL-ACP SYNTHASE II FROM ESCHERICHIA COLI
Descriptor: BETA-KETOACYL ACP SYNTHASE II
Authors:Huang, W, Jia, J, Edwards, P, Dehesh, K, Schneider, G, Lindqvist, Y.
Deposit date:1997-12-22
Release date:1999-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes.
EMBO J., 17, 1998
5KOF
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BU of 5kof by Molmil
Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and Acyl Carrier Protein, AcpP
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, [(3~{S})-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(prop-2-enoylamino)ethylamino]propyl]amino]butyl] dihydrogen phosphate
Authors:Milligan, J.C, Jackson, D.R, Barajas, J.F, Tsai, S.C.
Deposit date:2016-06-30
Release date:2018-01-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for interactions between an acyl carrier protein and a ketosynthase.
Nat.Chem.Biol., 15, 2019
4B7V
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BU of 4b7v by Molmil
Structure of wild type Pseudomonas aeruginosa FabF (KASII)
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2, POTASSIUM ION
Authors:Lecker, L, Baum, B, Zoltner, M, Hunter, W.N.
Deposit date:2012-08-22
Release date:2013-09-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form
Acta Crystallogr.,Sect.F, 71, 2015
6C9U
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Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab)
Descriptor: 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ...
Authors:Deis, L.N, Li, X, Mathews, I.I, Khosla, C.
Deposit date:2018-01-28
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
J. Am. Chem. Soc., 140, 2018
6P9L
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Crystal structure of Mycobacterium tuberculosis KasA in complex with JFX
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, 4-fluoro-N-(3-methyl-1H-indazol-5-yl)butane-1-sulfonamide, GLYCEROL, ...
Authors:Capodagli, G.C, Neiditch, M.B.
Deposit date:2019-06-10
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.305 Å)
Cite:A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Cell Chem Biol, 27, 2020
1OXH
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The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus Pneumoniae, Triclinic form
Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C, Rock, C.O, White, S.W.
Deposit date:2003-04-02
Release date:2003-04-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
6P9K
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BU of 6p9k by Molmil
Crystal structure of Mycobacterium tuberculosis KasA in complex with O6G
Descriptor: 3-oxoacyl-ACP synthase, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Capodagli, G.C, Neiditch, M.B.
Deposit date:2019-06-10
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Cell Chem Biol, 27, 2020
6WC7
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BU of 6wc7 by Molmil
Acyl carrier protein (ACP) domain bound to dehydratase (DH) domain in fungal fatty acid synthase (FAS)
Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
Authors:Lou, J.W, Mazhab-Jafari, M.T.
Deposit date:2020-03-29
Release date:2020-06-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase.
Commun Biol, 3, 2020
6FIJ
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BU of 6fij by Molmil
Structure of the loading/condensing region (SAT-KS-MAT) of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ...
Authors:Herbst, D.A, Jakob, R.P, Townsend, C.A, Maier, T.
Deposit date:2018-01-18
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
1TQY
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BU of 1tqy by Molmil
The Actinorhodin Ketosynthase/Chain Length Factor
Descriptor: ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ...
Authors:Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M.
Deposit date:2004-06-18
Release date:2004-07-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:An antibiotic factory caught in action.
Nat.Struct.Mol.Biol., 11, 2004
6Y2I
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BU of 6y2i by Molmil
Crystal structure of M. tuberculosis KasA in complex with N-(1H-indazol-5-yl)butane-1-sulfonamide
Descriptor: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, ...
Authors:Chung, C.
Deposit date:2020-02-16
Release date:2020-04-08
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.533 Å)
Cite:Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Acs Infect Dis., 6, 2020
6FIK
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BU of 6fik by Molmil
ACP2 crosslinked to the KS of the loading/condensing region of the CTB1 PKS
Descriptor: Polyketide synthase
Authors:Herbst, D.A, Huitt-Roehl, C.R, Jakob, R.P, Townsend, C.A, Maier, T.
Deposit date:2018-01-18
Release date:2018-03-21
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
1DD8
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BU of 1dd8 by Molmil
CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I FROM ESCHERICHIA COLI
Descriptor: BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I
Authors:Olsen, J.G, Kadziola, A, von Wettstein-Knowles, P, Siggaard-Andersen, M, Lindquist, Y, Larsen, S.
Deposit date:1999-11-09
Release date:1999-11-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I.
FEBS Lett., 460, 1999
3U0F
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BU of 3u0f by Molmil
The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin
Descriptor: 7-hydroxy-2H-chromen-2-one, Beta-ketoacyl synthase, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-09-28
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
1OX0
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BU of 1ox0 by Molmil
The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae
Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C, Rock, C.O, White, S.W.
Deposit date:2003-03-31
Release date:2003-04-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
1W0I
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BU of 1w0i by Molmil
Arabidopsis thaliana Mitochondrial KAS
Descriptor: 3-OXOACYL CARRIER PROTEIN SYNTHASE, POTASSIUM ION, SULFATE ION
Authors:Olsen, J.G, Rasmussen, A.V, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2004-06-04
Release date:2004-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis.
FEBS Lett., 577, 2004
3U0E
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Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320
Descriptor: 8-methylquinolin-4-amine, Beta-ketoacyl synthase, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-09-28
Release date:2011-10-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
1B3N
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BU of 1b3n by Molmil
BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.
Descriptor: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2)
Authors:Moche, M, Schneider, G, Edwards, P, Dehesh, K, Lindqvist, Y.
Deposit date:1998-12-14
Release date:1999-04-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase.
J.Biol.Chem., 274, 1999
2BZ4
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BU of 2bz4 by Molmil
structure of E.coli KAS I H298Q mutant
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, SULFATE ION
Authors:Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-08-10
Release date:2006-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006

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數據於2024-09-25公開中

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