1B3N

BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.

Summary for 1B3N

Entry DOI	10.2210/pdb1b3n/pdb
Descriptor	PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2), (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE (3 entities in total)
Functional Keywords	condensing enzymes, fatty acid elongation, cerulenin inhibition, lipid metabolism, drug design, drug target
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	43183.72
Authors	Moche, M.,Schneider, G.,Edwards, P.,Dehesh, K.,Lindqvist, Y. (deposition date: 1998-12-14, release date: 1999-04-06, Last modification date: 2023-12-27)
Primary citation	Moche, M.,Schneider, G.,Edwards, P.,Dehesh, K.,Lindqvist, Y. Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. J.Biol.Chem., 274:6031-6034, 1999 Cited by PubMed: 10037680 DOI: 10.1074/jbc.274.10.6031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation