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5X1O
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BU of 5x1o by Molmil
PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Fibroblast growth factor 2
Authors:Tsao, Y.H.
Deposit date:2017-01-26
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study
To Be Published
4YOL
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BU of 4yol by Molmil
Human fibroblast growth factor-1 C16S/A66C/C117A/P134A
Descriptor: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE
Authors:Xia, X, Blaber, M.
Deposit date:2015-03-11
Release date:2016-03-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
J.Pharm.Sci., 105, 2016
4CJM
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BU of 4cjm by Molmil
Crystal structure of human FGF18
Descriptor: FIBROBLAST GROWTH FACTOR 18, SULFATE ION
Authors:Brown, A, Adam, L.E, Blundell, T.L.
Deposit date:2013-12-21
Release date:2014-04-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Crystal Structure of Fibroblast Growth Factor 18 (Fgf18)
Protein Cell, 5, 2014
8OM6
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BU of 8om6 by Molmil
Crystal structure of FGF2-STAB, a stable variant of human fibroblast growth factor 2
Descriptor: Fibroblast growth factor 2
Authors:Marek, M, Chaloupkova, R, de La Bourdonnaye, G.
Deposit date:2023-03-31
Release date:2024-03-06
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Crystal structure of FGF2-STAB, a stable variant of human fibroblast growth factor 2
To Be Published
4XKI
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BU of 4xki by Molmil
Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R
Descriptor: Fibroblast growth factor 1, GLYCEROL, NONAETHYLENE GLYCOL, ...
Authors:Xia, X.
Deposit date:2015-01-12
Release date:2016-01-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biophysical characterizations of Fibroblast Growth Factor - 1 mutant with increased heparin binding affinity
To Be Published
2AFG
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BU of 2afg by Molmil
2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor: ACIDIC FIBROBLAST GROWTH FACTOR, SULFATE ION
Authors:Blaber, M, Disalvo, J, Thomas, K.A.
Deposit date:1995-07-21
Release date:1995-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray crystal structure of human acidic fibroblast growth factor.
Biochemistry, 35, 1996
1QQL
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BU of 1qql by Molmil
THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7/1 CHIMERA
Descriptor: FIBROBLAST GROWTH FACTOR 7/1 CHIMERA
Authors:Ye, S, Luo, Y, Pelletier, H, McKeehan, W.L.
Deposit date:1999-06-07
Release date:2000-01-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry, 40, 2001
1QQK
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BU of 1qqk by Molmil
THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7 (KERATINOCYTE GROWTH FACTOR)
Descriptor: FIBROBLAST GROWTH FACTOR 7
Authors:Ye, S, Luo, Y, Pelletier, H, McKeehan, W.L.
Deposit date:1999-06-07
Release date:2000-01-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry, 40, 2001
2AXM
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BU of 2axm by Molmil
HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR
Authors:Digabriele, A.D, Lax, I, Chen, D.I, Svahn, C.M, Jaye, M, Schlessinger, J, Hendrickson, W.A.
Deposit date:1997-10-20
Release date:1998-04-22
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
8HU7
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BU of 8hu7 by Molmil
Crystal structure of FGF2-M1 mutant - D28E/C78L/C96I/S137P
Descriptor: Fibroblast growth factor 2
Authors:Jung, Y.E, Cha, S.S, An, Y.J.
Deposit date:2022-12-22
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of FGF2-M1 mutant - D28E/C78L/C96I/S137P
To Be Published
8HUE
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BU of 8hue by Molmil
Crystal structure of FGF2-M2 mutant - D28E/C78I/C96I/S137P
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Fibroblast growth factor 2
Authors:Jung, Y.E, Cha, S.S, An, Y.J.
Deposit date:2022-12-23
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structure of FGF2-M2 mutant - D28E/C78I/C96I/S137P
To Be Published
4FGF
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BU of 4fgf by Molmil
REFINEMENT OF THE STRUCTURE OF HUMAN BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION AND ANALYSIS OF PRESUMED HEPARIN BINDING SITES BY SELENATE SUBSTITUTION
Descriptor: BASIC FIBROBLAST GROWTH FACTOR, BETA-MERCAPTOETHANOL, SULFATE ION
Authors:Eriksson, A.E, Matthews, B.W.
Deposit date:1993-02-26
Release date:1993-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution.
Protein Sci., 2, 1993
2Q9X
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BU of 2q9x by Molmil
Crystal structure of highly stable mutant Q40P/S47I/H93G of human fibroblast growth factor-1
Descriptor: GLYCEROL, Heparin-binding growth factor 1
Authors:Szlachcic, A, Zakrzewska, M, Krowarsch, D, Os, V, Helland, R, Otlewski, J.
Deposit date:2007-06-14
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of highly stable mutant Q40P/S47I/H93G of human fibroblast growth factor-1
To be Published
1RG8
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BU of 1rg8 by Molmil
Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form)
Descriptor: FORMIC ACID, Heparin-binding growth factor 1
Authors:Bernett, M.J, Somasundaram, T, Blaber, M.
Deposit date:2003-11-11
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:An atomic resolution structure for human fibroblast growth factor 1.
Proteins, 57, 2004
2RQ9
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BU of 2rq9 by Molmil
Solution structure of human acidic fibroblast growth factor (aFGF) in the presence of a protein stabilizer NDSB-new
Descriptor: Heparin-binding growth factor 1
Authors:Enomoto, M, Xiang, L, Ishii, T, Tochio, N, Hosoda, K, Inoue, Y, Nameki, N, Wakamatsu, K.
Deposit date:2009-03-12
Release date:2010-03-16
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of human acidic fibroblast growth factor (aFGF) in the presence of a protein stabilizer NDSB-new
To be Published
2UUS
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BU of 2uus by Molmil
Crystal structure of the rat FGF1-sucrose octasulfate (SOS) complex.
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, HEPARIN-BINDING GROWTH FACTOR 1
Authors:Kulahin, N, Kiselyov, V, Kochoyan, A, Kristensen, O, Berezin, V, Bock, E, Gajhede, M.
Deposit date:2007-03-07
Release date:2008-05-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dimerization Effect of Sucrose Octasulfate on Rat Fgf1.
Acta Crystallogr.,Sect.F, 64, 2008
1RML
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BU of 1rml by Molmil
NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES
Descriptor: ACIDIC FIBROBLAST GROWTH FACTOR, NAPHTHALENE TRISULFONATE
Authors:Lozano, R.M, Jimenez, M.A, Santoro, J, Rico, M, Gimenez-Gallego, G.
Deposit date:1998-05-21
Release date:1998-11-11
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas.
J.Mol.Biol., 281, 1998
2BFH
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BU of 2bfh by Molmil
CRYSTAL STRUCTURE OF BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION
Descriptor: BASIC FIBROBLAST GROWTH FACTOR
Authors:Kitagawa, Y, Ago, H, Katsube, Y, Fujishima, A, Matsuura, Y.
Deposit date:1993-08-31
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of basic fibroblast growth factor at 1.6 A resolution.
J.Biochem.(Tokyo), 110, 1991
1Z2V
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BU of 1z2v by Molmil
Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor
Descriptor: Heparin-binding growth factor 1, SULFATE ION
Authors:Lee, J, Blaber, M.
Deposit date:2005-03-09
Release date:2006-02-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: Effects upon structure, stability, folding, and mitogenic function.
Proteins, 62, 2006
2AQZ
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BU of 2aqz by Molmil
Crystal structure of FGF-1, S17T/N18T/G19 deletion mutant
Descriptor: Heparin-binding growth factor 1, SULFATE ION
Authors:Lee, J, Blaber, M.
Deposit date:2005-08-18
Release date:2006-02-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: Effects upon structure, stability, folding, and mitogenic function.
Proteins, 62, 2006
1Z4S
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BU of 1z4s by Molmil
Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor
Descriptor: Heparin-binding growth factor 1, SULFATE ION
Authors:Lee, J, Blaber, M.
Deposit date:2005-03-16
Release date:2006-02-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: Effects upon structure, stability, folding, and mitogenic function.
Proteins, 62, 2005
1YTO
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BU of 1yto by Molmil
Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor
Descriptor: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION
Authors:Lee, J, Blaber, M.
Deposit date:2005-02-10
Release date:2006-01-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: Effects upon structure, stability, folding, and mitogenic function.
Proteins, 62, 2006
2ERM
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BU of 2erm by Molmil
Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue
Descriptor: 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, ISOPROPYL ALCOHOL
Authors:Canales, A, Lozano, R, Nieto, P.M, Martin-Lomas, M, Gimenez-Gallego, G, Jimenez-Barbero, J.
Deposit date:2005-10-25
Release date:2006-10-03
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.
Febs J., 273, 2006
3UDA
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BU of 3uda by Molmil
Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex
Descriptor: 2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, PHOSPHATE ION
Authors:Hung, S.-C, Shi, Z.
Deposit date:2011-10-27
Release date:2012-11-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Divergent synthesis of 48 heparan sulfate-based disaccharides and probing the specific sugar-fibroblast growth factor-1 interaction
J.Am.Chem.Soc., 134, 2012
3UD9
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BU of 3ud9 by Molmil
Crystal Structure Analysis of FGF1-Disaccharide(NI23) complex
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, PHOSPHATE ION
Authors:Hung, S.-C, Shi, Z.
Deposit date:2011-10-27
Release date:2012-11-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Divergent synthesis of 48 heparan sulfate-based disaccharides and probing the specific sugar-fibroblast growth factor-1 interaction
J.Am.Chem.Soc., 134, 2012

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數據於2024-09-18公開中

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