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7OCK
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BU of 7ock by Molmil
MAT in complex with SAMH
分子名称: S-adenosylmethionine synthase, SAM hydrolase
著者Simon, H, Kleiner, D, Shmulevich, F, Zarivach, R, Zalk, R, Tang, H, Ding, F, Bershtein, S.
登録日2021-04-27
公開日2021-07-21
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献SAMase of Bacteriophage T3 Inactivates Escherichia coli's Methionine S -Adenosyltransferase by Forming Heteropolymers.
Mbio, 12, 2021
1QM4
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BU of 1qm4 by Molmil
Methionine Adenosyltransferase Complexed with a L-Methionine Analogue
分子名称: L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID, MAGNESIUM ION, METHIONINE ADENOSYLTRANSFERASE, ...
著者Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J.
登録日1999-09-20
公開日2000-09-21
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献The Crystal Structure of Tetrameric Methionine Adenosyltransferase from Rat Liver Reveals the Methionine-Binding Site
J.Mol.Biol., 300, 2000
6P9V
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BU of 6p9v by Molmil
Crystal Structure of hMAT Mutant K289L
分子名称: ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ...
著者Miller, M.D, Xu, W, Huber, T.D, Clinger, J.A, Liu, Y, Thorson, J.S, Phillips Jr, G.N.
登録日2019-06-10
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.051 Å)
主引用文献Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes.
Acs Chem.Biol., 15, 2020
8SWA
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BU of 8swa by Molmil
Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ...
著者Bruemmer, K.J, Pham, V.N, Toh, J.D.W.
登録日2023-05-18
公開日2023-11-15
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism.
Science, 382, 2023
5H9U
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BU of 5h9u by Molmil
Crystal structure of a thermostable methionine adenosyltransferase
分子名称: S-adenosylmethionine synthase
著者Feng, Y, Wang, W.
登録日2015-12-29
公開日2017-01-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.667 Å)
主引用文献Crystal structure of a thermostable methionine adenosyltransferase
To Be Published
3IML
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BU of 3iml by Molmil
Crystal Structure Of S-Adenosylmethionine Synthetase From Burkholderia Pseudomallei
分子名称: S-adenosylmethionine synthetase
著者Staker, B.L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-08-10
公開日2009-09-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
6WKB
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BU of 6wkb by Molmil
Human S-adenosylmethionine synthetase co-crystallized with UppNHp and Met
分子名称: 1,2-ETHANEDIOL, 5'-deoxyuridine, D-METHIONINE, ...
著者Tan, L.L, Jackson, C.J.
登録日2020-04-15
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献S-adenosylmethionine synthetase
To Be Published
6C07
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BU of 6c07 by Molmil
Crystal Structure of S-Adenosylmethionine synthetase (MetK/Mat) from Cryptosporidium parvum
分子名称: CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ...
著者Ohren, J.F, Viola, R.E.
登録日2017-12-28
公開日2019-01-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.
Acta Crystallogr F Struct Biol Commun, 75, 2019
5UGH
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BU of 5ugh by Molmil
Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366
分子名称: 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine, S-adenosylmethionine synthase isoform type-2
著者Kaiser, S.E, Feng, J, Stewart, A.E.
登録日2017-01-08
公開日2017-05-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.062 Å)
主引用文献Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
Nat. Chem. Biol., 13, 2017
1RG9
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BU of 1rg9 by Molmil
S-Adenosylmethionine synthetase complexed with SAM and PPNP
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ...
著者Komoto, J, Yamada, T, Takata, Y, Markham, G.D, Takusagawa, F.
登録日2003-11-11
公開日2004-03-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
4NDN
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BU of 4ndn by Molmil
Structural insights of MAT enzymes: MATa2b complexed with SAM and PPNP
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
著者Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L.
登録日2013-10-27
公開日2014-07-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Structure and function study of the complex that synthesizes S-adenosylmethionine.
IUCrJ, 1, 2014
1FUG
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BU of 1fug by Molmil
S-ADENOSYLMETHIONINE SYNTHETASE
分子名称: S-ADENOSYLMETHIONINE SYNTHETASE
著者Fu, Z, Markham, G.D, Takusagawa, F.
登録日1996-02-25
公開日1996-08-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Flexible loop in the structure of S-adenosylmethionine synthetase crystallized in the tetragonal modification.
J.Biomol.Struct.Dyn., 13, 1996
7L1A
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BU of 7l1a by Molmil
Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALANINE, MAGNESIUM ION, ...
著者Niland, C.N, Fedorov, E, Schramm, V.L, Ghosh, A.
登録日2020-12-14
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A.
Biochemistry, 60, 2021
7LNH
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BU of 7lnh by Molmil
S-adenosylmethionine synthetase co-crystallized with UppNHp
分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl-methyl-$l^{3}-sulfanyl]butanoic acid, 1,2-ETHANEDIOL, S-adenosylmethionine synthase isoform type-2
著者Tan, L.L, Jackson, C.J.
登録日2021-02-07
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases.
Jacs Au, 1, 2021
8AXZ
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BU of 8axz by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid.
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, ADENOSINE, DI(HYDROXYETHYL)ETHER, ...
著者Nawrotek, A, Vuillard, L, Miallau, L.
登録日2022-09-01
公開日2022-10-05
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.154 Å)
主引用文献Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid.
To Be Published
2OBV
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BU of 2obv by Molmil
Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product
分子名称: S-ADENOSYLMETHIONINE, S-adenosylmethionine synthetase isoform type-1, SODIUM ION, ...
著者Pilka, E.S, Shafqat, N, Kavanagh, K.L, Cooper, C, Hozjan, V, Turnbull, A, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2006-12-20
公開日2007-01-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
To be Published
7R3B
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BU of 7r3b by Molmil
S-adenosylmethionine synthetase from Lactobacillus plantarum complexed with AMPPNP, methionine and SAM
分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, PHENYLALANINE, ...
著者Shahar, A, Kleiner, D, Bershtein, S, Zarivach, R.
登録日2022-02-07
公開日2022-07-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure-function constrains.
Protein Sci., 31, 2022
7R2W
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BU of 7r2w by Molmil
Mutant S-adenosylmethionine synthetase from E.coli complexed with AMPPNP and methionine
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, POTASSIUM ION, ...
著者Shahar, A, Kleiner, D, Bershtein, S, Zarivach, R.
登録日2022-02-06
公開日2022-07-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure-function constrains.
Protein Sci., 31, 2022
6LTV
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BU of 6ltv by Molmil
Crystal Structure of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine)
分子名称: MAGNESIUM ION, S-adenosylmethionine synthase, TRIPHOSPHATE, ...
著者Singh, R.K, Michailidou, F, Rentmeister, A, Kuemmel, D.
登録日2020-01-23
公開日2020-10-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions.
Angew.Chem.Int.Ed.Engl., 60, 2021
8BB1
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BU of 8bb1 by Molmil
T3 SAM lyase in complex with S-adenosylmethionine synthase
分子名称: CHLORIDE ION, S-Adenosylmethionine lyase, S-adenosylmethionine synthase
著者Triguis, S, Selmer, M.
登録日2022-10-12
公開日2023-08-23
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase.
Cell Rep, 42, 2023
6LTW
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BU of 6ltw by Molmil
Crystal structure of Apo form of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis
分子名称: MAGNESIUM ION, PHOSPHATE ION, S-adenosylmethionine synthase
著者Singh, R.K, Michailidou, F, Rentmeister, A, Kuemmel, D.
登録日2020-01-23
公開日2020-10-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions.
Angew.Chem.Int.Ed.Engl., 60, 2021
2P02
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BU of 2p02 by Molmil
Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2
分子名称: CHLORIDE ION, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthetase isoform type-2
著者Papagrigoriou, E, Shafqat, N, Rojkova, A, Niessen, F.H, Kavanagh, K.L, von Delft, F, Gorrec, F, Ugochukwu, E, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2007-02-28
公開日2007-03-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2
To be Published
5T8S
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BU of 5t8s by Molmil
Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound S-adenosylmethionine, AMP, Pyrophosphate, Phosphate, and Magnesium
分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2016-09-08
公開日2016-09-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound S-adenosylmethionine, AMP, Pyrophosphate, Phosphate, and Magnesium
to be published
4KTT
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BU of 4ktt by Molmil
Structural insights of MAT enzymes: MATa2b complexed with SAM
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Methionine adenosyltransferase 2 subunit beta, ...
著者Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L.
登録日2013-05-21
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structure and function study of the complex that synthesizes S-adenosylmethionine.
IUCrJ, 1, 2014
4KTV
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BU of 4ktv by Molmil
Structural insights of MAT enzymes: MATa2b complexed with adenosine and pyrophosphate
分子名称: 1,2-ETHANEDIOL, ADENOSINE, MAGNESIUM ION, ...
著者Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L.
登録日2013-05-21
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure and function study of the complex that synthesizes S-adenosylmethionine.
IUCrJ, 1, 2014

 

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