Summary
| Title: | Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938 |
| Citation: | Gong, G.Q.,Bilanges, B.,Allsop, B.,Masson, G.R.,Roberton, V.,Askwith, T.,Oxenford, S.,Madsen, R.R.,Conduit, S.E.,Bellini, D.,Fitzek, M.,Collier, M.,Najam, O.,He, Z.,Wahab, B.,McLaughlin, S.H.,Chan, A.W.E.,Feierberg, I.,Madin, A.,Morelli, D.,Bhamra, A.,Vinciauskaite, V.,Anderson, K.E.,Surinova, S.,Pinotsis, N.,Lopez-Guadamillas, E.,Wilcox, M.,Hooper, A.,Patel, C.,Whitehead, M.A.,Bunney, T.D.,Stephens, L.R.,Hawkins, P.T.,Katan, M.,Yellon, D.M.,Davidson, S.M.,Smith, D.M.,Phillips, J.B.,Angell, R.,Williams, R.L.,Vanhaesebroeck, B. A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618:159-168, 2023 PubMed: 37225977DOI: 10.1038/s41586-023-05972-2 |
| Experimental method: | X-RAY DIFFRACTION (2.57 Å) |
| Deposition date: | 2022-10-26 |
| Release date: | 2023-01-18 |
| Obsoletion date: | 2023-05-24 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 8bfv.cif.gz Display(240.36 KB) 8bfv.cif | ||
| PDBx/mmJSON | no-atom | 8bfv-noatom.json.gz Display (Header)(23.67 KB) 8bfv-noatom.json | |
| PDBML | all | 8bfv.xml.gz Display(299.62 KB) 8bfv.xml | |
| PDB | pdb8bfv.ent.gz Display(154.59 KB) pdb8bfv.ent | ||
| Structure factors | r8bfvsf.ent.gz Display(1002.59 KB) r8bfvsf.ent | ||
