Summary
| Title: | Structure of human DPP-IV with HTS hit (2S,3S,11bS)-3-Butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine |
| Citation: | Mattei, P.,Boehringer, M.,Di Giorgio, P.,Fischer, H.,Hennig, M.,Huwyler, J.,Kocer, B.,Kuhn, B.,Loeffler, B.M.,Macdonald, A.,Narquizian, R.,Rauber, E.,Sebokova, E.,Sprecher, U. Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg.Med.Chem.Lett., 20:1109-1113, 2010 PubMed: 20031405DOI: 10.1016/j.bmcl.2009.12.024 |
| Experimental method: | X-RAY DIFFRACTION (2.7 Å) |
| Deposition date: | 2009-12-01 |
| Release date: | 2010-01-12 |
| Obsoletion date: | 2010-08-25 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 3kwh.cif.gz Display(296.57 KB) 3kwh.cif | ||
| PDBML | all | 3kwh.xml.gz Display(407.67 KB) 3kwh.xml | |
| PDB | pdb3kwh.ent.gz Display(250.44 KB) pdb3kwh.ent | ||
| Structure factors | r3kwhsf.ent.gz Display(815.33 KB) r3kwhsf.ent | ||
