9Z6T
Human HCN1 in complex with cAMP in nanodisc
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGAvGKkMYFIqhG |
| Chain | Residue | Details |
| A | ILE502-GLY518 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 148 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 52 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O88704","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
