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9YND

Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B and LIS1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001673cellular_componentmale germ cell nucleus
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005868cellular_componentcytoplasmic dynein complex
A0005874cellular_componentmicrotubule
A0005881cellular_componentcytoplasmic microtubule
A0005938cellular_componentcell cortex
A0007052biological_processmitotic spindle organization
A0007097biological_processnuclear migration
A0008090biological_processretrograde axonal transport
A0008569molecular_functionminus-end-directed microtubule motor activity
A0016020cellular_componentmembrane
A0030175cellular_componentfilopodium
A0031122biological_processcytoplasmic microtubule organization
A0032388biological_processpositive regulation of intracellular transport
A0033962biological_processP-body assembly
A0034063biological_processstress granule assembly
A0035578cellular_componentazurophil granule lumen
A0042802molecular_functionidentical protein binding
A0045505molecular_functiondynein intermediate chain binding
A0051293biological_processestablishment of spindle localization
A0051959molecular_functiondynein light intermediate chain binding
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0090235biological_processregulation of metaphase plate congression
A0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904115cellular_componentaxon cytoplasm
A1905832biological_processpositive regulation of spindle assembly
B0000132biological_processestablishment of mitotic spindle orientation
B0000226biological_processmicrotubule cytoskeleton organization
B0000235cellular_componentastral microtubule
B0000776cellular_componentkinetochore
B0001675biological_processacrosome assembly
B0001764biological_processneuron migration
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005871cellular_componentkinesin complex
B0005875cellular_componentmicrotubule associated complex
B0005938cellular_componentcell cortex
B0007017biological_processmicrotubule-based process
B0007097biological_processnuclear migration
B0007268biological_processchemical synaptic transmission
B0007399biological_processnervous system development
B0007405biological_processneuroblast proliferation
B0007611biological_processlearning or memory
B0008017molecular_functionmicrotubule binding
B0008090biological_processretrograde axonal transport
B0008201molecular_functionheparin binding
B0008247cellular_component1-alkyl-2-acetylglycerophosphocholine esterase complex
B0008344biological_processadult locomotory behavior
B0010977biological_processnegative regulation of neuron projection development
B0015630cellular_componentmicrotubule cytoskeleton
B0017145biological_processstem cell division
B0019226biological_processtransmission of nerve impulse
B0021540biological_processcorpus callosum morphogenesis
B0021766biological_processhippocampus development
B0021819biological_processlayer formation in cerebral cortex
B0021895biological_processcerebral cortex neuron differentiation
B0021987biological_processcerebral cortex development
B0030036biological_processactin cytoskeleton organization
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030900biological_processforebrain development
B0031023biological_processmicrotubule organizing center organization
B0031252cellular_componentcell leading edge
B0031514cellular_componentmotile cilium
B0031965cellular_componentnuclear membrane
B0031982cellular_componentvesicle
B0032420cellular_componentstereocilium
B0034452molecular_functiondynactin binding
B0038026biological_processreelin-mediated signaling pathway
B0040019biological_processpositive regulation of embryonic development
B0042249biological_processestablishment of planar polarity of embryonic epithelium
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043274molecular_functionphospholipase binding
B0043622biological_processcortical microtubule organization
B0044877molecular_functionprotein-containing complex binding
B0045505molecular_functiondynein intermediate chain binding
B0045773biological_processpositive regulation of axon extension
B0045931biological_processpositive regulation of mitotic cell cycle
B0046469biological_processplatelet activating factor metabolic process
B0046982molecular_functionprotein heterodimerization activity
B0047496biological_processvesicle transport along microtubule
B0048471cellular_componentperinuclear region of cytoplasm
B0048854biological_processbrain morphogenesis
B0050804biological_processmodulation of chemical synaptic transmission
B0050885biological_processneuromuscular process controlling balance
B0051012biological_processmicrotubule sliding
B0051130biological_processpositive regulation of cellular component organization
B0051219molecular_functionphosphoprotein binding
B0051656biological_processestablishment of organelle localization
B0051660biological_processestablishment of centrosome localization
B0060117biological_processauditory receptor cell development
B0061003biological_processpositive regulation of dendritic spine morphogenesis
B0062234biological_processplatelet activating factor catabolic process
B0070062cellular_componentextracellular exosome
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070840molecular_functiondynein complex binding
B0090102biological_processcochlea development
B0090176biological_processmicrotubule cytoskeleton organization involved in establishment of planar polarity
B0090724cellular_componentcentral region of growth cone
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098978cellular_componentglutamatergic synapse
B0099175biological_processregulation of postsynapse organization
B1904115cellular_componentaxon cytoplasm
C0000132biological_processestablishment of mitotic spindle orientation
C0000226biological_processmicrotubule cytoskeleton organization
C0000235cellular_componentastral microtubule
C0000776cellular_componentkinetochore
C0001675biological_processacrosome assembly
C0001764biological_processneuron migration
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005871cellular_componentkinesin complex
C0005875cellular_componentmicrotubule associated complex
C0005938cellular_componentcell cortex
C0007017biological_processmicrotubule-based process
C0007097biological_processnuclear migration
C0007268biological_processchemical synaptic transmission
C0007399biological_processnervous system development
C0007405biological_processneuroblast proliferation
C0007611biological_processlearning or memory
C0008017molecular_functionmicrotubule binding
C0008090biological_processretrograde axonal transport
C0008201molecular_functionheparin binding
C0008247cellular_component1-alkyl-2-acetylglycerophosphocholine esterase complex
C0008344biological_processadult locomotory behavior
C0010977biological_processnegative regulation of neuron projection development
C0015630cellular_componentmicrotubule cytoskeleton
C0017145biological_processstem cell division
C0019226biological_processtransmission of nerve impulse
C0021540biological_processcorpus callosum morphogenesis
C0021766biological_processhippocampus development
C0021819biological_processlayer formation in cerebral cortex
C0021895biological_processcerebral cortex neuron differentiation
C0021987biological_processcerebral cortex development
C0030036biological_processactin cytoskeleton organization
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0030900biological_processforebrain development
C0031023biological_processmicrotubule organizing center organization
C0031252cellular_componentcell leading edge
C0031514cellular_componentmotile cilium
C0031965cellular_componentnuclear membrane
C0031982cellular_componentvesicle
C0032420cellular_componentstereocilium
C0034452molecular_functiondynactin binding
C0038026biological_processreelin-mediated signaling pathway
C0040019biological_processpositive regulation of embryonic development
C0042249biological_processestablishment of planar polarity of embryonic epithelium
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043274molecular_functionphospholipase binding
C0043622biological_processcortical microtubule organization
C0044877molecular_functionprotein-containing complex binding
C0045505molecular_functiondynein intermediate chain binding
C0045773biological_processpositive regulation of axon extension
C0045931biological_processpositive regulation of mitotic cell cycle
C0046469biological_processplatelet activating factor metabolic process
C0046982molecular_functionprotein heterodimerization activity
C0047496biological_processvesicle transport along microtubule
C0048471cellular_componentperinuclear region of cytoplasm
C0048854biological_processbrain morphogenesis
C0050804biological_processmodulation of chemical synaptic transmission
C0050885biological_processneuromuscular process controlling balance
C0051012biological_processmicrotubule sliding
C0051130biological_processpositive regulation of cellular component organization
C0051219molecular_functionphosphoprotein binding
C0051656biological_processestablishment of organelle localization
C0051660biological_processestablishment of centrosome localization
C0060117biological_processauditory receptor cell development
C0061003biological_processpositive regulation of dendritic spine morphogenesis
C0062234biological_processplatelet activating factor catabolic process
C0070062cellular_componentextracellular exosome
C0070507biological_processregulation of microtubule cytoskeleton organization
C0070840molecular_functiondynein complex binding
C0090102biological_processcochlea development
C0090176biological_processmicrotubule cytoskeleton organization involved in establishment of planar polarity
C0090724cellular_componentcentral region of growth cone
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098978cellular_componentglutamatergic synapse
C0099175biological_processregulation of postsynapse organization
C1904115cellular_componentaxon cytoplasm
D0000132biological_processestablishment of mitotic spindle orientation
D0000226biological_processmicrotubule cytoskeleton organization
D0000235cellular_componentastral microtubule
D0000776cellular_componentkinetochore
D0001675biological_processacrosome assembly
D0001764biological_processneuron migration
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005871cellular_componentkinesin complex
D0005875cellular_componentmicrotubule associated complex
D0005938cellular_componentcell cortex
D0007017biological_processmicrotubule-based process
D0007097biological_processnuclear migration
D0007268biological_processchemical synaptic transmission
D0007399biological_processnervous system development
D0007405biological_processneuroblast proliferation
D0007611biological_processlearning or memory
D0008017molecular_functionmicrotubule binding
D0008090biological_processretrograde axonal transport
D0008201molecular_functionheparin binding
D0008247cellular_component1-alkyl-2-acetylglycerophosphocholine esterase complex
D0008344biological_processadult locomotory behavior
D0010977biological_processnegative regulation of neuron projection development
D0015630cellular_componentmicrotubule cytoskeleton
D0017145biological_processstem cell division
D0019226biological_processtransmission of nerve impulse
D0021540biological_processcorpus callosum morphogenesis
D0021766biological_processhippocampus development
D0021819biological_processlayer formation in cerebral cortex
D0021895biological_processcerebral cortex neuron differentiation
D0021987biological_processcerebral cortex development
D0030036biological_processactin cytoskeleton organization
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0030900biological_processforebrain development
D0031023biological_processmicrotubule organizing center organization
D0031252cellular_componentcell leading edge
D0031514cellular_componentmotile cilium
D0031965cellular_componentnuclear membrane
D0031982cellular_componentvesicle
D0032420cellular_componentstereocilium
D0034452molecular_functiondynactin binding
D0038026biological_processreelin-mediated signaling pathway
D0040019biological_processpositive regulation of embryonic development
D0042249biological_processestablishment of planar polarity of embryonic epithelium
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043274molecular_functionphospholipase binding
D0043622biological_processcortical microtubule organization
D0044877molecular_functionprotein-containing complex binding
D0045505molecular_functiondynein intermediate chain binding
D0045773biological_processpositive regulation of axon extension
D0045931biological_processpositive regulation of mitotic cell cycle
D0046469biological_processplatelet activating factor metabolic process
D0046982molecular_functionprotein heterodimerization activity
D0047496biological_processvesicle transport along microtubule
D0048471cellular_componentperinuclear region of cytoplasm
D0048854biological_processbrain morphogenesis
D0050804biological_processmodulation of chemical synaptic transmission
D0050885biological_processneuromuscular process controlling balance
D0051012biological_processmicrotubule sliding
D0051130biological_processpositive regulation of cellular component organization
D0051219molecular_functionphosphoprotein binding
D0051656biological_processestablishment of organelle localization
D0051660biological_processestablishment of centrosome localization
D0060117biological_processauditory receptor cell development
D0061003biological_processpositive regulation of dendritic spine morphogenesis
D0062234biological_processplatelet activating factor catabolic process
D0070062cellular_componentextracellular exosome
D0070507biological_processregulation of microtubule cytoskeleton organization
D0070840molecular_functiondynein complex binding
D0090102biological_processcochlea development
D0090176biological_processmicrotubule cytoskeleton organization involved in establishment of planar polarity
D0090724cellular_componentcentral region of growth cone
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098978cellular_componentglutamatergic synapse
D0099175biological_processregulation of postsynapse organization
D1904115cellular_componentaxon cytoplasm
E0000132biological_processestablishment of mitotic spindle orientation
E0000226biological_processmicrotubule cytoskeleton organization
E0000235cellular_componentastral microtubule
E0000776cellular_componentkinetochore
E0001675biological_processacrosome assembly
E0001764biological_processneuron migration
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005635cellular_componentnuclear envelope
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005871cellular_componentkinesin complex
E0005875cellular_componentmicrotubule associated complex
E0005938cellular_componentcell cortex
E0007017biological_processmicrotubule-based process
E0007097biological_processnuclear migration
E0007268biological_processchemical synaptic transmission
E0007399biological_processnervous system development
E0007405biological_processneuroblast proliferation
E0007611biological_processlearning or memory
E0008017molecular_functionmicrotubule binding
E0008090biological_processretrograde axonal transport
E0008201molecular_functionheparin binding
E0008247cellular_component1-alkyl-2-acetylglycerophosphocholine esterase complex
E0008344biological_processadult locomotory behavior
E0010977biological_processnegative regulation of neuron projection development
E0015630cellular_componentmicrotubule cytoskeleton
E0017145biological_processstem cell division
E0019226biological_processtransmission of nerve impulse
E0021540biological_processcorpus callosum morphogenesis
E0021766biological_processhippocampus development
E0021819biological_processlayer formation in cerebral cortex
E0021895biological_processcerebral cortex neuron differentiation
E0021987biological_processcerebral cortex development
E0030036biological_processactin cytoskeleton organization
E0030424cellular_componentaxon
E0030426cellular_componentgrowth cone
E0030900biological_processforebrain development
E0031023biological_processmicrotubule organizing center organization
E0031252cellular_componentcell leading edge
E0031514cellular_componentmotile cilium
E0031965cellular_componentnuclear membrane
E0031982cellular_componentvesicle
E0032420cellular_componentstereocilium
E0034452molecular_functiondynactin binding
E0038026biological_processreelin-mediated signaling pathway
E0040019biological_processpositive regulation of embryonic development
E0042249biological_processestablishment of planar polarity of embryonic epithelium
E0042802molecular_functionidentical protein binding
E0043025cellular_componentneuronal cell body
E0043274molecular_functionphospholipase binding
E0043622biological_processcortical microtubule organization
E0044877molecular_functionprotein-containing complex binding
E0045505molecular_functiondynein intermediate chain binding
E0045773biological_processpositive regulation of axon extension
E0045931biological_processpositive regulation of mitotic cell cycle
E0046469biological_processplatelet activating factor metabolic process
E0046982molecular_functionprotein heterodimerization activity
E0047496biological_processvesicle transport along microtubule
E0048471cellular_componentperinuclear region of cytoplasm
E0048854biological_processbrain morphogenesis
E0050804biological_processmodulation of chemical synaptic transmission
E0050885biological_processneuromuscular process controlling balance
E0051012biological_processmicrotubule sliding
E0051130biological_processpositive regulation of cellular component organization
E0051219molecular_functionphosphoprotein binding
E0051656biological_processestablishment of organelle localization
E0051660biological_processestablishment of centrosome localization
E0060117biological_processauditory receptor cell development
E0061003biological_processpositive regulation of dendritic spine morphogenesis
E0062234biological_processplatelet activating factor catabolic process
E0070062cellular_componentextracellular exosome
E0070507biological_processregulation of microtubule cytoskeleton organization
E0070840molecular_functiondynein complex binding
E0090102biological_processcochlea development
E0090176biological_processmicrotubule cytoskeleton organization involved in establishment of planar polarity
E0090724cellular_componentcentral region of growth cone
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098978cellular_componentglutamatergic synapse
E0099175biological_processregulation of postsynapse organization
E1904115cellular_componentaxon cytoplasm
F0001673cellular_componentmale germ cell nucleus
F0003777molecular_functionmicrotubule motor activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005868cellular_componentcytoplasmic dynein complex
F0005874cellular_componentmicrotubule
F0007018biological_processmicrotubule-based movement
F0010970biological_processtransport along microtubule
F0031982cellular_componentvesicle
F0032388biological_processpositive regulation of intracellular transport
F0036157cellular_componentouter dynein arm
F0045503molecular_functiondynein light chain binding
F0045504molecular_functiondynein heavy chain binding
F0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
G0001673cellular_componentmale germ cell nucleus
G0003777molecular_functionmicrotubule motor activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005813cellular_componentcentrosome
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005868cellular_componentcytoplasmic dynein complex
G0005874cellular_componentmicrotubule
G0007018biological_processmicrotubule-based movement
G0010970biological_processtransport along microtubule
G0031982cellular_componentvesicle
G0032388biological_processpositive regulation of intracellular transport
G0036157cellular_componentouter dynein arm
G0045503molecular_functiondynein light chain binding
G0045504molecular_functiondynein heavy chain binding
G0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
Functional Information from PROSITE/UniProt
site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS
ChainResidueDetails
AILE2216-SER2226

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF
ChainResidueDetails
BLEU165-PHE179
BILE207-VAL221
BLEU311-VAL325
BVAL395-CYS409

site_idPS00845
Number of Residues32
DetailsCAP_GLY_1 CAP-Gly domain signature. Gatlfatgk..WvGVilDeak....GKNdGTvqGrkYF
ChainResidueDetails
HGLY48-PHE79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues231
DetailsRegion: {"description":"AAA 1","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues249
DetailsRegion: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues269
DetailsRegion: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues229
DetailsRegion: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues216
DetailsRegion: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues79
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues28
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues82
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues78
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues78
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues78
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues59
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues82
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues64
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues84
DetailsRegion: {"description":"Interaction with DCX","evidences":[{"source":"PubMed","id":"11001923","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues44
DetailsRegion: {"description":"Interaction with NDEL1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues64
DetailsDomain: {"description":"LisH","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues130
DetailsRegion: {"description":"Interaction with NDE1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues74
DetailsRegion: {"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

251174

PDB entries from 2026-03-25

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