9YND
Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B and LIS1
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS |
| Chain | Residue | Details |
| A | ILE2216-SER2226 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF |
| Chain | Residue | Details |
| B | LEU165-PHE179 | |
| B | ILE207-VAL221 | |
| B | LEU311-VAL325 | |
| B | VAL395-CYS409 |
| site_id | PS00845 |
| Number of Residues | 32 |
| Details | CAP_GLY_1 CAP-Gly domain signature. Gatlfatgk..WvGVilDeak....GKNdGTvqGrkYF |
| Chain | Residue | Details |
| H | GLY48-PHE79 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 231 |
| Details | Region: {"description":"AAA 1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 249 |
| Details | Region: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 269 |
| Details | Region: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 229 |
| Details | Region: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 216 |
| Details | Region: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 79 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 59 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 64 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 84 |
| Details | Region: {"description":"Interaction with DCX","evidences":[{"source":"PubMed","id":"11001923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 44 |
| Details | Region: {"description":"Interaction with NDEL1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 64 |
| Details | Domain: {"description":"LisH","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 130 |
| Details | Region: {"description":"Interaction with NDE1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 74 |
| Details | Region: {"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
