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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9YKN

The structure of the cardiac native crossbridge in the rigor state, myosin heads with essential and regulatory light chains bound to actin molecules 6 and 7

Functional Information from GO Data
ChainGOidnamespacecontents
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0007015biological_processactin filament organization
A0010628biological_processpositive regulation of gene expression
A0015629cellular_componentactin cytoskeleton
A0017022molecular_functionmyosin binding
A0030017cellular_componentsarcomere
A0030027cellular_componentlamellipodium
A0030175cellular_componentfilopodium
A0033275biological_processactin-myosin filament sliding
A0044297cellular_componentcell body
A0060047biological_processheart contraction
A0090131biological_processmesenchyme migration
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0007015biological_processactin filament organization
B0010628biological_processpositive regulation of gene expression
B0015629cellular_componentactin cytoskeleton
B0017022molecular_functionmyosin binding
B0030017cellular_componentsarcomere
B0030027cellular_componentlamellipodium
B0030175cellular_componentfilopodium
B0033275biological_processactin-myosin filament sliding
B0044297cellular_componentcell body
B0060047biological_processheart contraction
B0090131biological_processmesenchyme migration
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0007015biological_processactin filament organization
C0015629cellular_componentactin cytoskeleton
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0046982molecular_functionprotein heterodimerization activity
C0051015molecular_functionactin filament binding
C0060048biological_processcardiac muscle contraction
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0007015biological_processactin filament organization
D0015629cellular_componentactin cytoskeleton
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0046982molecular_functionprotein heterodimerization activity
D0051015molecular_functionactin filament binding
D0060048biological_processcardiac muscle contraction
E0005856cellular_componentcytoskeleton
E0005884cellular_componentactin filament
E0007015biological_processactin filament organization
E0015629cellular_componentactin cytoskeleton
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0046982molecular_functionprotein heterodimerization activity
E0051015molecular_functionactin filament binding
E0060048biological_processcardiac muscle contraction
F0005856cellular_componentcytoskeleton
F0005884cellular_componentactin filament
F0007015biological_processactin filament organization
F0015629cellular_componentactin cytoskeleton
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0046982molecular_functionprotein heterodimerization activity
F0051015molecular_functionactin filament binding
F0060048biological_processcardiac muscle contraction
H0000146molecular_functionmicrofilament motor activity
H0005737cellular_componentcytoplasm
H0007512biological_processadult heart development
H0016460cellular_componentmyosin II complex
H0030016cellular_componentmyofibril
H0030017cellular_componentsarcomere
H0030049biological_processmuscle filament sliding
H0032982cellular_componentmyosin filament
H0051015molecular_functionactin filament binding
H0060048biological_processcardiac muscle contraction
I0000146molecular_functionmicrofilament motor activity
I0005737cellular_componentcytoplasm
I0007512biological_processadult heart development
I0016460cellular_componentmyosin II complex
I0030016cellular_componentmyofibril
I0030017cellular_componentsarcomere
I0030049biological_processmuscle filament sliding
I0032982cellular_componentmyosin filament
I0051015molecular_functionactin filament binding
I0060048biological_processcardiac muscle contraction
J0002026biological_processregulation of the force of heart contraction
J0003774molecular_functioncytoskeletal motor activity
J0003785molecular_functionactin monomer binding
J0006942biological_processregulation of striated muscle contraction
J0016460cellular_componentmyosin II complex
J0031672cellular_componentA band
J0031674cellular_componentI band
J0055010biological_processventricular cardiac muscle tissue morphogenesis
J0060048biological_processcardiac muscle contraction
K0002026biological_processregulation of the force of heart contraction
K0003774molecular_functioncytoskeletal motor activity
K0003785molecular_functionactin monomer binding
K0006942biological_processregulation of striated muscle contraction
K0016460cellular_componentmyosin II complex
K0031672cellular_componentA band
K0031674cellular_componentI band
K0055010biological_processventricular cardiac muscle tissue morphogenesis
K0060048biological_processcardiac muscle contraction
L0003785molecular_functionactin monomer binding
L0005509molecular_functioncalcium ion binding
L0005737cellular_componentcytoplasm
L0005856cellular_componentcytoskeleton
L0007507biological_processheart development
L0008307molecular_functionstructural constituent of muscle
L0015629cellular_componentactin cytoskeleton
L0030016cellular_componentmyofibril
L0030308biological_processnegative regulation of cell growth
L0042694biological_processmuscle cell fate specification
L0055010biological_processventricular cardiac muscle tissue morphogenesis
L0060048biological_processcardiac muscle contraction
L0097512cellular_componentcardiac myofibril
L0098735biological_processpositive regulation of the force of heart contraction
M0003785molecular_functionactin monomer binding
M0005509molecular_functioncalcium ion binding
M0005737cellular_componentcytoplasm
M0005856cellular_componentcytoskeleton
M0007507biological_processheart development
M0008307molecular_functionstructural constituent of muscle
M0015629cellular_componentactin cytoskeleton
M0030016cellular_componentmyofibril
M0030308biological_processnegative regulation of cell growth
M0042694biological_processmuscle cell fate specification
M0055010biological_processventricular cardiac muscle tissue morphogenesis
M0060048biological_processcardiac muscle contraction
M0097512cellular_componentcardiac myofibril
M0098735biological_processpositive regulation of the force of heart contraction
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DQNRDGFIDknDL
ChainResidueDetails
LASP37-LEU49
site_idPS00326
Number of Residues9
DetailsTROPOMYOSIN Tropomyosins signature. LKEAEtRAE
ChainResidueDetails
CLEU232-GLU240
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63
site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
ATRP356-GLU364
site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P58771","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues50
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues98
DetailsDomain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1386
DetailsDomain: {"description":"Myosin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues58
DetailsDomain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues72
DetailsRegion: {"description":"Actin-binding"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

258009

PDB entries from 2026-08-12

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